Uterine prostaglandin F metabolite production in relation to glucose availability in late pregnancy and a possible influence of diet on time of delivery in the mare.
Abstract: The production of uterine PGFM during different dietary states has been investigated in pregnant mares in late gestation. Arterial and uterine venous plasma concentrations of PGFM rose when food was withdrawn for 12-30 h and the V-A difference widened significantly. There was an inverse correlation between the rise in PGFM and the fall in plasma glucose during a fast, and a significant decrease in the A-V plasma glucose differences across the uterus. Plasma PGFM and free fatty acid concentrations before and during food withdrawal were also correlated but no uterine A-V difference in free fatty acids could be detected. An immediate fall in uterine PGFM levels occurred upon refeeding or infusion of glucose, which was more closely correlated with the rise in plasma glucose than the fall in free fatty acids, both of which occurred after restoration of nutrient. No detectable alterations in uterine blood flow occurred during a fast/feed cycle and hence A-V or V-A differences across the uterus gave an indication of uptake or output. PGFM production increased 5 times during a fast and glucose uptake decreased by about 70%. Basal levels were restored by 1-3 h after feeding or glucose infusion. Daily fluctuations in plasma PGFM concentrations were closely associated with the time of the morning feed of concentrates. The overnight rise in PGFM was greatest in late gestation. Five of the 8 mares delivered prematurely within 1 week of the last period of food withdrawal. Attention is drawn to the consequences of inadequate or intermittent feeding on premature delivery.
Publication Date: 1982-01-01 PubMed ID: 6962892
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- Journal Article
Summary
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The research investigates the impact of dietary conditions on uterine PGFM production in pregnant mares during late pregnancy, and how it might influence the timing of delivery. It suggests that inadequate or intermittent feeding could lead to premature birth.
Study Design and Methodology
- Researchers examined the production of uterine Prostaglandin F Metabolite (PGFM) in pregnant mares during different dietary states in late pregnancy.
- Their arterial and uterine venous plasma concentrations of PGFM were measured during periods of food withdrawal lasting from 12 to 30 hours.
- Various other parameters such as plasma glucose levels, free fatty acids levels, and uterine blood flow were also closely monitored during this fasting/feeding cycle.
Key Findings
- The plasma concentrations of PGFM increased when food was withdrawn and the difference between its arterial and venous concentrations also significantly widened under such conditions.
- The rise of PGFM was inversely correlated to the fall of plasma glucose during fasting periods.
- Interestingly, an immediate drop in uterine PGFM levels occurred upon refeeding or glucose infusion.
- Plasma PGFM increased five times during fasting, while glucose uptake by the uterus decreased by about 70% during the same period. These basal levels returned to normal within varying periods of 1–3 hours after feeding or glucose infusion.
- The researchers also found a strong association between daily fluctuations in plasma PGFM concentrations and the time of the morning feed.
Premature Delivery and Feeding Patterns
- An important observation from the study was the evidence of premature delivery among the test subjects.
- Five out of eight mares delivered prematurely within a week after their last period of food withdrawal, highlighting a possible link between feeding patterns and the timing of delivery.
Implications of the Study
- The study draws attention to possible consequences of inadequate or intermittent feeding on the timing of delivery in late pregnancy.
- It suggests that changes in dietary patterns can induce physiological changes that could potentially lead to premature delivery.
- These findings underscore the need for a consistent and adequate feeding schedule for pregnant mares to avoid premature delivery.
Cite This Article
APA
Silver M, Fowden AL.
(1982).
Uterine prostaglandin F metabolite production in relation to glucose availability in late pregnancy and a possible influence of diet on time of delivery in the mare.
J Reprod Fertil Suppl, 32, 511-519.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Delivery, Obstetric
- Diet
- Fatty Acids / metabolism
- Fatty Acids, Nonesterified / blood
- Female
- Glucose / metabolism
- Horses / physiology
- Labor, Obstetric
- Pregnancy
- Pregnancy, Animal
- Prostaglandins F
- Prostanoic Acids / metabolism
- Uterus / metabolism
Citations
This article has been cited 7 times.- Nulty AK, Bovbjerg ML, Herring AH, Siega-Riz AM, Thorp JM Jr, Evenson KR. Meal patterning and the onset of spontaneous labor.. Birth 2022 Mar;49(1):123-131.
- Englund-Ögge L, Birgisdottir BE, Sengpiel V, Brantsæter AL, Haugen M, Myhre R, Meltzer HM, Jacobsson B. Meal frequency patterns and glycemic properties of maternal diet in relation to preterm delivery: Results from a large prospective cohort study.. PLoS One 2017;12(3):e0172896.
- Chen PY, Ganguly A, Rubbi L, Orozco LD, Morselli M, Ashraf D, Jaroszewicz A, Feng S, Jacobsen SE, Nakano A, Devaskar SU, Pellegrini M. Intrauterine calorie restriction affects placental DNA methylation and gene expression.. Physiol Genomics 2013 Jul 15;45(14):565-76.
- Madej A, Mwanza AM, Kindahl H, Einarsson S. Effect of ACTH and CRH on plasma levels of cortisol and prostaglandin F2alpha metabolite in cycling gilts and castrated boars.. Acta Vet Scand 2005;46(4):249-56.
- Fowden AL, Taylor PM, White KL, Forhead AJ. Ontogenic and nutritionally induced changes in fetal metabolism in the horse.. J Physiol 2000 Oct 1;528 Pt 1(Pt 1):209-19.
- Holst H, Kindahl H. Hematological and blood biochemical effects of fasting and subsequent oral administration of endotoxin in prepubertal gifts.. Acta Vet Scand 1995;36(4):499-508.
- Fowden AL, Harding R, Ralph MM, Thorburn GD. The nutritional regulation of plasma prostaglandin E concentrations in the fetus and pregnant ewe during late gestation.. J Physiol 1987 Dec;394:1-12.
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