Uveal inflammation in septic newborn foals.
Abstract: Septicemia in humans is described as a leading cause of uveitis, which eventually can induce blindness. Objective: Uveal inflammatory findings could be related to sepsis severity in newborn foals and might be used as an indirect indicator for survival. Methods: Seventy-four septic foals, 54 nonseptic foals, and 42 healthy foals. Methods: Prospective observational clinical study. A detailed blinded, ophthalmic examination was performed by boarded ophthalmologists on all admitted newborn foals. Foals were grouped as septic (when blood culture resulted positive or the sepsis score was > or =14), nonseptic, and controls. Based on blood culture results, the septic group was subdivided into bacteremic and nonbacteremic foals. Results: Blood culture was performed in 62/74 septic foals, from which 35 (56%) were bacteremic and 27 (44%) were non-bacteremic. Anterior uveitis was diagnosed in a significantly (P < .005) higher number of septic/bacteremic foals (14/35, 40%) than in septic/nonbacteremic foals (5/27, 19%), nonseptic foals (4/54, 7%), and control foals (0%). Anterior chamber fibrin was only observed in 4/14 (29%) septic/bacteremic foals with anterior uveitis. Anterior uveitis was also associated with posterior uveitis in 6/35 (19%) septic/bacteremic foals. The diagnosis of uveitis was related to nonsurvival (P = .001, odds ratio = 6.2, 95% confidence interval = 2.1-18.2). Conclusions: Anterior uveitis is highly prevalent in septic newborn foals, especially in those with a positive blood culture, and it should be considered as a survival prognostic factor.
Publication Date: 2010-01-07 PubMed ID: 20051000DOI: 10.1111/j.1939-1676.2009.0452.xGoogle Scholar: Lookup
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- Journal Article
Summary
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This research studied the levels of uveal inflammation among newborn foals with sepsis, comparing it with that of non-septic and healthy foals, and its potential to act as an indicator for survival. It revealed a higher prevalence of the inflammatory eye disease, specifically anterior uveitis, amongst septic foals especially those with a positive blood culture and an associated impact on survival rates.
Methodology
- The study was a prospective observation of 74 septic foals, 54 non-septic foals, and 42 healthy foals.
- All the foals were subjected to a detailed, blinded ophthalmic examination by boarded ophthalmologists.
- Foals were classified into septic if they had a positive blood culture or a sepsis score of >=14, nonseptic, and controls.
- The septic group was further divided into bacteremic and non-bacteremic foals based on blood culture results.
Results
- Out of 74 septic foals, a blood culture was done for 62 of which 35 (56%) were found to be bacteremic and 27 (44%) as non-bacteremic.
- Anterior uveitis was significantly higher in septic/bacteremic foals (40%) as compared to septic/non-bacteremic foals (19%), nonseptic foals (7%), and control foals (0%).
- Of the septic/bacteremic foals diagnosed with anterior uveitis, only 29% showed fibrin in the anterior chamber.
- 19% of septic/bacteremic foals with anterior uveitis were also associated with posterior uveitis.
Conclusion
- The likelihood of non-survival was connected with the diagnosis of uveitis (odds ratio = 6.2, 95% confidence interval = 2.1-18.2).
- Anterior uveitis was found to be highly prevalent in septic newborn foals, particularly in those with a positive blood culture.
- Therefore, the presence of anterior uveitis in septic foals should be considered as a prognostic indicator for survival.
Cite This Article
APA
Leiva M, Peña T, Armengou L, Cesarini C, Monreal L.
(2010).
Uveal inflammation in septic newborn foals.
J Vet Intern Med, 24(2), 391-397.
https://doi.org/10.1111/j.1939-1676.2009.0452.x Publication
Researcher Affiliations
- Servei d'Oftalmologia Veterinària, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain.
MeSH Terms
- Animals
- Animals, Newborn
- Female
- Horse Diseases / pathology
- Horses
- Male
- Prospective Studies
- Sepsis / complications
- Sepsis / veterinary
- Uveitis / complications
- Uveitis / pathology
- Uveitis / veterinary
Citations
This article has been cited 2 times.- Wollanke B, Gerhards H, Ackermann K. Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis. Microorganisms 2022 Feb 7;10(2).
- Flores MM, Del Piero F, Habecker PL, Langohr IM. A retrospective histologic study of 140 cases of clinically significant equine ocular disorders. J Vet Diagn Invest 2020 May;32(3):382-388.
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