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Veterinary journal (London, England : 1997)2011; 191(2); 199-202; doi: 10.1016/j.tvjl.2011.01.019

Vaccination elicits a prominent acute phase response in horses.

Abstract: European and American guidelines for vaccination against tetanus and influenza in horses recommend annual and annual/semi-annual vaccinations, respectively, against the two pathogens. Too-frequent vaccination may, however, have adverse effects, among other things because an inflammatory response is elicited with subsequent alterations in homeostasis. The objective of the study was to compare the acute phase response (APR) in 10 horses following administration of two different types of vaccines, namely, an inactivated Immune Stimulating COMplex (ISCOM) vaccine and a live recombinant vector vaccine. Blood was sampled before and after vaccination to measure levels of serum amyloid A (SAA), fibrinogen, white blood cell counts (WBC) and iron. Vaccination induced a prominent APR with increased WBC, elevated blood levels of SAA and fibrinogen, and decreased serum iron concentrations. The ISCOM vaccine caused significantly (P<0.05) greater SAA, fibrinogen and WBC responses than the vector vaccine. During the APR muscle catabolism and liver and kidney metabolism are altered. Also drug metabolism may change during the APR. The findings of the present study may be relevant for advising horse owners about convalescence after vaccination.
Copyright © 2011 Elsevier Ltd. All rights reserved.
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Publication Date: 2011-03-02 PubMed ID: 21371917DOI: 10.1016/j.tvjl.2011.01.019Google Scholar: Lookup
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  • Clinical Trial
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article investigates the effects of vaccination on horses, specifically their acute phase response (APR) to two types of vaccines. The findings suggest that too frequent vaccination can cause an inflammatory response and changes to homeostasis. Furthermore, one vaccine (the inactivated Immune Stimulating Complex vaccine), was found to cause a more significant response than the other type (the live recombinant vector vaccine).

Study Objective

  • The main aim of this research was to examine the APR in horses after they had been administered with two different vaccines. The vaccines tested were an inactivated Immune Stimulating Complex (ISCOM) vaccine and a live recombinant vector vaccine. The study sought to understand how these vaccines affected the health and homeostasis of the horses.

Methodology

  • Blood samples were collected from 10 horses before and after they were vaccinated. The researchers then measured the levels of serum amyloid A (SAA), fibrinogen, white blood cell counts (WBC) and iron in these samples.

Pivotal Findings

  • The researchers found that vaccination induced a notable APR in the horses, marked by increased white blood cell counts, raised blood levels of serum amyloid A and fibrinogen, and decreased serum iron concentrations.
  • The ISCOM vaccine was found to cause significantly (P<0.05) greater serum amyloid A, fibrinogen and white blood cell responses than the vector vaccine.
  • During the APR, changes were noticed in the horses’ muscle catabolism as well as their liver and kidney metabolism.
  • The research also suggested that drug metabolism could change during APR.

Implications

  • The findings have important implications for the health and well-being of horses and how they are cared for following vaccination.
  • If horses receive too frequent vaccinations, they could exhibit an inflammatory response and changes in homeostasis, the body’s internal state of equilibrium.
  • The research could guide veterinary professionals and horse owners in understanding what kind of vaccine is most suitable and the appropriate frequency of vaccination.

Cite This Article

APA
Andersen SA, Petersen HH, Ersbøll AK, Falk-Rønne J, Jacobsen S. (2011). Vaccination elicits a prominent acute phase response in horses. Vet J, 191(2), 199-202. https://doi.org/10.1016/j.tvjl.2011.01.019

Publication

Veterinary journal (London, England : 1997)
ISSN: 1532-2971
NlmUniqueID: 9706281
Country: England
Language: English
Volume: 191
Issue: 2
Pages: 199-202

Researcher Affiliations

Andersen, Susanne A
  • Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Taastrup, Denmark.
Petersen, Henrik H
    Ersbøll, Annette K
      Falk-Rønne, Jørgen
        Jacobsen, Stine

          MeSH Terms

          • Acute-Phase Reaction / blood
          • Acute-Phase Reaction / chemically induced
          • Acute-Phase Reaction / veterinary
          • Animals
          • Female
          • Fibrinogen / metabolism
          • Horse Diseases / blood
          • Horse Diseases / immunology
          • Horse Diseases / prevention & control
          • Horses
          • ISCOMs / adverse effects
          • Leukocyte Count / veterinary
          • Male
          • Serum Amyloid A Protein / metabolism
          • Vaccination / adverse effects
          • Vaccination / veterinary
          • Vaccines, Synthetic / adverse effects

          Citations

          This article has been cited 22 times.
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