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Home/Equine Research Bank/J Vet Intern Med/Vaccination for the prevention of equine herpesvirus-1 disea...
Journal of veterinary internal medicine2023; doi: 10.1111/jvim.16895

Vaccination for the prevention of equine herpesvirus-1 disease in domesticated horses: A systematic review and meta-analysis.

Abstract: Equine herpes virus type 1 (EHV-1) infection in horses is associated with respiratory and neurologic disease, abortion, and neonatal death. Objective: Vaccines decrease the occurrence of clinical disease in EHV-1-infected horses. Methods: A systematic review was performed searching multiple databases to identify relevant studies. Selection criteria were original peer-reviewed research reports that investigated the in vivo use of vaccines for the prevention of disease caused by EHV-1 in domesticated horses. Main outcomes of interest included pyrexia, abortion, neurologic disease, viremia, and nasal shedding. We evaluated risk of bias, conducted exploratory meta-analyses of incidence data for the main outcomes, and performed a GRADE evaluation of the quality of evidence for each vaccine subtype. Results: A total of 1018 unique studies were identified, of which 35 met the inclusion criteria. Experimental studies accounted for 31/35 studies, with the remainder being observational studies. Eight vaccine subclasses were identified including commercial (modified-live, inactivated, mixed) and experimental (modified-live, inactivated, deletion mutant, DNA, recombinant). Risk of bias was generally moderate, often because of underreporting of research methods, and sample sizes were small leading to imprecision in the estimate of the effect size. Several studies reported either no benefit or minimal vaccine efficacy for the primary outcomes of interest. Meta-analyses revealed significant heterogeneity was present, and our confidence in the quality of evidence for most outcomes was low to moderate. Conclusions: Our review indicates that commercial and experimental vaccines minimally reduce the incidence of clinical disease associated with EHV-1 infection.
© 2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
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Publication Date: 2023-11-06 PubMed ID: 37930113DOI: 10.1111/jvim.16895Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The article is about a systemic review and meta-analysis study to evaluate the efficacy of various vaccines in preventing equine herpes virus type 1 (EHV-1) diseases in horses. The study concludes that both commercial and experimental vaccines offer minimal reduction in the incidence of clinical diseases linked to EHV-1 infection.

Research Methodology

  • The researchers conducted a comprehensive systematic review pulling data from multiple databases to identify relevant studies about EHV-1 vaccines. The selection criteria were confined to original peer-reviewed studies that examined the in vivo use of vaccines for preventing diseases triggered by EHV-1 in horses.
  • Several outcomes of interest were considered in this review including fever (pyrexia), abortion, neurological disease, viremia, and nasal shedding.
  • The team analyzed the risk of bias, performed meta-analyses of incidence data for every identified outcome and carried out a GRADE evaluation of evidence quality for each vaccine subtype.

Results

  • A total of 1018 unique studies were identified during the review process and 35 of these met the inclusion criteria.
  • The large majority (31 out of 35) of these studies were experimental while the remainder were observational in nature.
  • Eight different subclasses of vaccines were identified in these studies including commercial forms (modified-live, inactivated, mixed) and experimental forms (modified-live, inactivated, deletion mutant, DNA, recombinant).
  • The risk of bias was generally moderate due to a frequent under-reporting research methodologies, and small sample sizes that led to imprecision in the estimate of effect size.
  • Many studies concluded either no or limited efficacy of the vaccine in relation to the primary outcomes of interest.
  • Significant heterogeneity was discovered within the meta-analyses with the research team holding low to moderate confidence in the quality of the evidence for most outcomes.

Conclusion

  • The systematic review reveals that both commercial and experimental vaccines offer minimal reduction in the occurrence of clinical disease associated with EHV-1 infection in horses.

Cite This Article

APA
Osterrieder K, Dorman DC, Burgess BA, Goehring LS, Gross P, Neinast C, Pusterla N, Hussey GS, Lunn DP. (2023). Vaccination for the prevention of equine herpesvirus-1 disease in domesticated horses: A systematic review and meta-analysis. J Vet Intern Med. https://doi.org/10.1111/jvim.16895

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English

Researcher Affiliations

Osterrieder, Klaus
  • Institut fu00fcr Virologie, Freie Universitu00e4t Berlin, Berlin, Germany.
Dorman, David C
  • College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Burgess, Brandy A
  • College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Goehring, Lutz S
  • College of Agriculture, Food and Environment, University of Kentucky, Maxwell H. Gluck Equine Research Center, Lexington, Kentucky, USA.
Gross, Peggy
  • College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Neinast, Claire
  • College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Pusterla, Nicola
  • School of Veterinary Medicine, University of California, Davis, California, USA.
Hussey, Gisela Soboll
  • College of Veterinary Medicine, Michigan State University, Veterinary Medical Center, East Lansing, Michigan, USA.
Lunn, David P
  • School of Veterinary Science, University of Liverpool, Liverpool, UK.

References

This article includes 56 references
  1. Oladunni FS, Horohov DW, Chambers TM. EHV-1: a constant threat to the horse industry. Front Microbiol. 2019;10:2668.
  2. Lunn DP, Davis-Poynter N, Flaminio MJBF, et al. Equine herpesvirus-1 consensus statement. J Vet Intern Med. 2009;23:450-461.
  3. Allen GP, Kydd JH, Slater JD, et al. Equid herpesvirus 1 and equid herpesvirus 4 infections. In: Coetzer JAW, Tustin RC, eds. Infectious Diseases of Livestock. 1st ed. Newmarket: Oxford University Press; 2004:829-859.
  4. Kydd JH, Smith KC, Hannant D, et al. Distribution of equid herpesvirus-1 (EHV-1) in the respiratory tract of ponies: implications for vaccination strategies. Equine Vet J. 1994;26:466-469.
  5. Kydd JH, Smith KC, Hannant D, et al. Distribution of equid herpesvirus-1 (EHV-1) in respiratory tract associated lymphoid tissue: implications for cellular immunity. Equine Vet J. 1994;26:470-473.
  6. Foote CE, Love DN, Gilkerson JR, Whalley JM. Detection of EHV-1 and EHV-4 DNA in unweaned thoroughbred foals from vaccinated mares on a large stud farm. Equine Vet J. 2004;36:341-345.
  7. Henninger RW, Reed SM, Saville WJ, et al. Outbreak of neurologic disease caused by equine herpesvirus-1 at a university equestrian center. J Vet Intern Med. 2007;21:157-165.
  8. Management of an EHV-1 outbreak at FEI events and its international impact. Vet Rec 2021;189:e905.
  9. Traub-Dargatz JL, Pelzel-McCluskey AM, Creekmore LH, et al. Case-control study of a multistate equine herpesvirus myeloencephalopathy outbreak. J Vet Intern Med. 2013;27:339-346.
  10. Higgins JPT, Chandler J, Cumpston M, et al. Cochrane Handbook for Systematic Reviews of Interventions. Chichester: John Wiley & Sons; 2020.
  11. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
  12. Hooijmans CR, Rovers MM, de Vries RB, et al. SYRCLE's risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14:43.
  13. Moller S, Ahrenfeldt LJ. Estimating relative risk when observing zero events-frequentist inference and Bayesian credibility intervals. Int J Environ Res Public Health. 2021;18(11):5527 doi:10.3390/ijerph18115527.
  14. Deeks JJ, Higgins JPT, Altman DG. Analysing data and undertaking meta-analyses. In: Higgins JPT, Thomas J, Chandler J, et al., eds. Cochrane Handbook for Systematic Reviews of Interventions Version 6.3.Chichester, UK:u00a0Cochrane; 2022.
  15. Guyatt GH, Oxman AD, Schunemann HJ, et al. GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol. 2011;64:380-382.
  16. Breathnach CC, Yeargan MR, Sheoran AS, et al. The mucosal humoral immune response of the horse to infective challenge and vaccination with equine herpesvirus-1 antigens. Equine Vet J. 2001;33:651-657.
  17. National Academies of Sciences, Engineering, and Medicine; Division on Earth and Life Studies; Board on Environmental Studies and Toxicology; Committee on Endocrine-Related Low-Dose Toxicity. Application of Systematic Review Methods in an overall Strategy for Evaluating Low-Dose Toxicity From Endocrine Active Chemicals. Washington, DC: The National Academies Press; 2017.
  18. Office of Health Assessment and Translation (OHAT). Handbook for Conducting a Literature-Base Health Assessment Using OHAT Approach for Systematic Review and Evidence Integration. Bethesda, MD, USA: National Institute of Environmental Health Sciences; 2019.
  19. Barrandeguy ME, Lascombes F, Llorente J, Houssay H, Fernandez F. High case-rate equine herpesvirus-1 abortion outbreak in vaccinated polo mares in Argentina. Equine Vet Educ. 2002;14:132-135.
  20. Bannai H, Kokado H, Matsumura T, et al. Epizootiological investigation of equine herpesvirus type 1 infection among Japanese racehorses before and after the replacement of an inactivated vaccine with a modified live vaccine. BMC Vet Res. 2019;15:280.
  21. Dutta SK, Shipley WD. Immunity and the level of neutralization antibodies in foals and mares vaccinated with a modified live-virus rhinopneumonitis vaccine. Am J Vet Res. 1975;36:445-448.
  22. Kydd JH, Wattrang E, Hannant D. Pre-infection frequencies of equine herpesvirus-1 specific, cytotoxic T lymphocytes correlate with protection against abortion following experimental infection of pregnant mares. Vet Immunol Immunopathol. 2003;96:207-217.
  23. Heldens JG, Hannant D, Cullinane AA, et al. Clinical and virological evaluation of the efficacy of an inactivated EHV1 and EHV4 whole virus vaccine (Duvaxyn EHV1,4). Vaccination/challenge experiments in foals and pregnant mares. Vaccine. 2001;19:4307-4317.
  24. Mitchell D, Girard A, Papp-Vid G. A challenge study on pregnant pony mares following vaccination with a modified live equine herpesvirus 1 (EHV 1) vaccine. J Equine Med Surg. 1978;1:69-73.
  25. Purdy CW, Ford SJ, Porter RC. Equine rhinopneumonitis vaccine: immunogenicity and safety in adult horses, including pregnant mares. Am J Vet Res. 1978;39:377-383.
  26. Burrows R, Goodridge D, Denyer MS. Trials of an inactivated equid herpesvirus 1 vaccine: challenge with a subtype 1 virus. Vet Rec. 1984;114:369-374.
  27. Goodman LB, Wagner B, Flaminio MJ, et al. Comparison of the efficacy of inactivated combination and modified-live virus vaccines against challenge infection with neuropathogenic equine herpesvirus type 1 (EHV-1). Vaccine. 2006;24:3636-3645.
  28. Hannant D, Jessett DM, O'Neill T, Dolby CA, Cook RF, Mumford JA. Responses of ponies to equid herpesvirus-1 ISCOM vaccination and challenge with virus of the homologous strain. Res Vet Sci. 1993;54:299-305.
  29. Perkins G, Babasyan S, Stout AE, et al. Intranasal IgG4/7 antibody responses protect horses against equid herpesvirus-1 (EHV-1) infection including nasal virus shedding and cell-associated viremia. Virology. 2019;531:219-232.
  30. Minke JM, Fischer L, Baudu P, et al. Use of DNA and recombinant canarypox viral (ALVAC) vectors for equine herpes virus vaccination. Vet Immunol Immunopathol. 2006;111:47-57.
  31. Tsujimura K, Shiose T, Yamanaka T, et al. Equine herpesvirus type 1 mutant defective in glycoprotein E gene as candidate vaccine strain. J Vet Med Sci. 2009;71:1439-1448.
  32. Goehring LS, Wagner B, Bigbie R, et al. Control of EHV-1 viremia and nasal shedding by commercial vaccines. Vaccine. 2010;28:5203-5211.
  33. Schnabel CL, Babasyan S, Rollins A, et al. An equine herpesvirus type 1 (EHV-1) Ab4 open reading frame 2 deletion mutant provides immunity and protection from EHV-1 infection and disease. J Virol. 2019;93(22):e01011-19.
  34. Kydd JH, Hannant D, Robinson RS, Bryant N, Osterrieder N. Vaccination of foals with a modified live, equid herpesvirus-1 gM deletion mutant (RacHDeltagM) confers partial protection against infection. Vaccine. 2020;38:388-398.
  35. Cornick J, Martens J, Martens R, Crandell R, McConnell S, Kit S. Safety and efficacy of a thymidine kinase negative equine herpesvirus-1 vaccine in young horses. Can J Vet Res. 1990;54:260-266.
  36. Paillot R, Ellis SA, Daly JM, et al. Characterisation of CTL and IFN-gamma synthesis in ponies following vaccination with a NYVAC-based construct coding for EHV-1 immediate early gene, followed by challenge infection. Vaccine. 2006;24:1490-1500.
  37. Thomson GR, Mumford JA, Smith IM. Experimental immunization against respiratory disease due to equid herpesvirus 1 infection (rhinopneumonitis) using formalin-inactivated virus with various adjuvants. Vet Microbiol. 1979;4:209-222.
  38. van de Walle GR, May MA, Peters ST, et al. A vectored equine herpesvirus type 1 (EHV-1) vaccine elicits protective immune responses against EHV-1 and H3N8 equine influenza virus. Vaccine. 2010;28:1048-1055.
  39. Burki F, Rossmanith W, Nowotny N, et al. Viraemia and abortions are not prevented by two commercial equine herpesvirus-1 vaccines after experimental challenge of horses. Vet Q. 1990;12:80-86.
  40. Mohd-Azmi ML, Gibson J, Rixon F, et al. Protection of specific-pathogen-free (Spf) foals from severe equine herpesvirus type-1 (Ehv-1) infection following immunization with non-infectious L-particles. J Microbiol. 2002;40:183-192.
  41. Bannai H, Nemoto M, Tsujimura K, et al. Comparison of protective efficacies between intranasal and intramuscular vaccination of horses with a modified live equine herpesvirus type-1 vaccine. Vet Microbiol. 2018;222:18-24.
  42. Mumford JA, Bates J. Trials of an inactivated equid herpesvirus-1 vaccine - challenge with a subtype-2 virus. Vet Rec. 1984;114:375-381.
  43. Patel JR, Bateman H, Williams J, Didlick S. Derivation and characterisation of a live equid herpes virus-1 (EHV-1) vaccine to protect against abortion and respiratory disease due to EHV-1. Vet Microbiol. 2003;91:23-39.
  44. Soboll G, Breathnach CC, Kydd JH, Hussey SB, Mealey RM, Lunn DP. Vaccination of ponies with the IE gene of EHV-1 in a recombinant modified live vaccinia vector protects against clinical and virological disease. Vet Immunol Immunopathol. 2010;135:108-117.
  45. Purdy CW, Porter RC, Ford SJ. Equine rhinopneumonitis vaccine: immunogenicity and safety in foals. Am J Vet Res. 1978;39:745-752.
  46. Patel JR, Didlick S, Bateman H. Efficacy of a live equine herpesvirus-1 (EHV-1) strain C147 vaccine in foals with maternally-derived antibody: protection against EHV-1 infection. Equine Vet J. 2004;36:447-451.
  47. Dolby CA, Hannant D, Mumford JA. Response of ponies to adjuvanted EHV-1 whole virus vaccine and challenge with virus of the homologous strain. Br Vet J. 1995;151:27-37.
  48. Patel JR, Fu00f6ldi J, Bateman H, Williams J, Didlick S, Stark R. Equid herpesvirus (EHV-1) live vaccine strain C147: efficacy against respiratory diseases following EHV types 1 and 4 challenges. Vet Microbiol. 2003;92:1-17.
  49. Wagner B, Perkins G, Babasyan S, et al. Neonatal immunization with a single IL-4/antigen dose induces increased antibody responses after challenge infection with equine herpesvirus type 1 (EHV-1) at weanling age. PLoS One. 2017;12:e0169072.
  50. Rufiange M, Rousseau-Blass F, Pang DSJ. Incomplete reporting of experimental studies and items associated with risk of bias in veterinary research. Vet Rec Open. 2019;6:e000322.
  51. Di Girolamo N, Giuffrida MA, Winter AL, et al. In veterinary trials reporting and communication regarding randomisation procedures is suboptimal. Vet Rec. 2017;181:195.
  52. Alpi KM, Vo TA, Dorman DC. Language consideration and methodological transparency in u201csystematicu201d reviews of animal toxicity studies. Int J Toxicol. 2019;38:135-145.
  53. Hooijmans CR, de Vries R, Leenaars M, Curfs J, Ritskes-Hoitinga M. Improving planning, design, reporting and scientific quality of animal experiments by using the Gold Standard Publication Checklist, in addition to the ARRIVE guidelines. Br J Pharmacol. 2011;162:1259-1260.
  54. Conway A, Conway Z, Soalheira K, Sutherland J. High quality of evidence is uncommon in Cochrane systematic reviews in Anaesthesia, Critical Care and Emergency Medicine. Eur J Anaesthesiol. 2017;34:808-813.
  55. Pandis N, Fleming PS, Worthington H, Salanti G. The quality of the evidence according to GRADE is predominantly low or very low in oral health systematic reviews. PloS One. 2015;10:e0131644.
  56. Marenzoni ML, De Waure C, Timoney PJ. Efficacy of vaccination against equine herpesvirus type 1 (EHV-1) infection: systematic review and meta-analysis of randomised controlled challenge trials. Equine Vet J. 2022;55:389-404.

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