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Home / Equine Research Bank / Emerg Infect Dis / West Nile virus, Guadeloupe.
Emerging infectious diseases2004; 10(4); 706-708; doi: 10.3201/eid1004.030465

West Nile virus, Guadeloupe.

Abstract: To determine whether West Nile virus (WNV) had reached the archipelago of Guadeloupe, a serologic study in horses and birds was conducted in 2002. Immunoglobulin (Ig) G, IgM, enzyme-linked immunosorbent assay, and seroneutralization tests identified WNV infection in horses and chickens. Six months later, a high rate of seroconversion was observed in horses.
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Publication Date: 2004-06-18 PubMed ID: 15200864PubMed Central: PMC3323088DOI: 10.3201/eid1004.030465Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research study reveals that West Nile virus (WNV) has spread to the archipelago of Guadeloupe, as evidenced from 2002 tests on horses and birds utilizing various assays and seroneutralization approaches.

Methodology of the Research

  • The team carried out a serologic study in 2002 to ascertain whether the West Nile virus had reached Guadeloupe. This involved examining the presence of specific immune responses in serum samples, mainly of horses and birds for this research.
  • In the serological tests, the researchers checked for Immunoglobulin G (IgG) and Immunoglobulin M (IgM) – classes of antibodies that respectively indicate either a past infection or a current active infection.
  • They also employed an Enzyme-Linked Immunosorbent Assay (ELISA), which is a commonly used laboratory test to detect and measure antibodies in blood. This test could, therefore, reaffirm the presence of antibodies against WNV in the test subjects.
  • Further, the researchers implemented seroneutralization tests. These tests quantify a subject’s seroresponse to a pathogen by determining the concentration of antibodies that can neutralize or inhibit the pathogen’s effects. In this case, the test would provide evidence of an immune response to WNV.

Findings of the Research

  • The research confirms the presence of the West Nile virus in Guadeloupe. The presence of IgG and IgM, as well as the results of the ELISA test and seroneutralization tests, proved WNV infection in the examined horses and chickens. These serological markers implied both past and current infections, demonstrating that the virus had been circulating in the local animal population.
  • The researchers also observed a high rate of seroconversion in horses six months following this study. This means there was an increase in the number of these animals that developed specific antibodies against the WNV during this period. This observation further strengthened the case for the existent and ongoing transmission of WNV in the area.

Impact and Implications of the Research

  • This study contributes to our understanding of the geographic spread of the West Nile virus. It demonstrates that infected animals can help track the migration and expansion of the virus, beneficial for planning appropriate public health responses.
  • The finding is of particular concern since it demonstrates the spread of a disease that can also be harmful to humans, extending to a new geographical location, which may necessitate new strategies in zoonotic disease control and prevention in the region.

Cite This Article

APA
Quirin R, Salas M, Zientara S, Zeller H, Labie J, Murri S, Lefrançois T, Petitclerc M, Martinez D. (2004). West Nile virus, Guadeloupe. Emerg Infect Dis, 10(4), 706-708. https://doi.org/10.3201/eid1004.030465

Publication

Emerging infectious diseases
ISSN: 1080-6040
NlmUniqueID: 9508155
Country: United States
Language: English
Volume: 10
Issue: 4
Pages: 706-708

Researcher Affiliations

Quirin, René
  • Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Petit Bourg, Guadeloupe, French West Indies.
Salas, Michel
    Zientara, Stéphan
      Zeller, Hervé
        Labie, Jacques
          Murri, Séverine
            Lefrançois, Thierry
              Petitclerc, Martial
                Martinez, Dominique

                  MeSH Terms

                  • Animals
                  • Antibodies, Viral / blood
                  • Birds / virology
                  • Chickens / virology
                  • Cross-Sectional Studies
                  • Enzyme-Linked Immunosorbent Assay
                  • Guadeloupe
                  • Horses / virology
                  • Neutralization Tests
                  • West Nile virus / immunology
                  • West Nile virus / isolation & purification

                  References

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                  This article has been cited 17 times.
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