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Home / Equine Research Bank / Arch Virol / West Nile virus in the vertebrate world.
Archives of virology2005; 150(4); 637-657; doi: 10.1007/s00705-004-0463-z

West Nile virus in the vertebrate world.

Abstract: West Nile virus (WNV), an arthropod-borne virus belonging to the family Flaviviridae, had been recognized in Africa, Asia and the south of Europe for many decades. Only recently, it has been associated with an increasing number of outbreaks of encephalitis in humans and equines as well as an increasing number of infections in vertebrates of a wide variety of species. In this article, the data available on the incidence of WNV in vertebrates are reviewed. Moreover, the role of vertebrates in the transmission of WNV, the control of WNV infections in veterinary medicine as well as future perspectives are discussed. A wide variety of vertebrates, including more than 150 bird species and at least 30 other vertebrate species, are susceptible to WNV infection. The outcome of infection depends on the species, the age of the animal, its immune status and the pathogenicity of the WNV isolate. WNV infection of various birds, especially passeriforms, but also of young chickens and domestic geese, results in high-titred viremia that allows arthropod-borne transmission. For other vertebrate species, only lemurs, lake frogs and hamsters develop suitable viremia levels to support arthropod-borne transmission. The role of vertebrates in direct, non-arthropod-borne transmission, such as via virus-contaminated organs, tissues or excretions is less well characterized. Even though direct transmission can occur among vertebrates of several species, data are lacking on the exact amounts of infectious virus needed. Finally, the increased importance of WNV infections has led to the development of killed, live-attenuated, DNA-recombinant and chimeric veterinary vaccines.
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Publication Date: 2005-01-19 PubMed ID: 15662484DOI: 10.1007/s00705-004-0463-zGoogle Scholar: Lookup
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Summary

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The article presents a comprehensive review of the incidence, transmission, and control of West Nile virus (WNV) infections among various vertebrate species, emphasizing the virus’s extensive host range and the development of veterinary vaccines against the infection.

Overview of West Nile Virus in Vertebrates

The research paper begins with a general introduction to West Nile Virus (WNV), a member of the Flaviviridae family, originally detected in Africa, Asia, and southern parts of Europe. WNV has increasingly been linked with outbreaks of encephalitis in humans and equines as well as infections in a wide range of vertebrate species:

  • Over 150 bird species and at least 30 other types of vertebrates are susceptible to WNV.
  • The severity of the infection can depend on the species, the age of the animal, its immune status, and the pathogenicity of the WNV strain.

Transmission of West Nile Virus

The paper then focuses on the transmission of WNV among vertebrates:

  • Certain birds like passeriforms, young chickens, and domestic geese exhibit high levels of viremia (presence of the virus in the bloodstream), thereby allowing the virus to be transmitted through arthropods (insects).
  • In other vertebrates such as lemurs, lake frogs, and hamsters, appropriate viremia levels for arthropod-borne transmission can also be developed.
  • However, the role of vertebrates in non-arthropod-borne transmission, such as through virus-infected organs, tissues, or excretions, is less clear, with more research needed to determine the amounts of infectious virus necessary for this type of transmission.

Control of West Nile Virus Infections

Regarding the control of WNV infections in veterinary medicine and future perspectives, the article underlines:

  • The growing significance of WNV infections has led to the development of various types of veterinary vaccines, including killed, live-attenuated, DNA-recombinant, and chimeric vaccines.

In conclusion, the article emphasizes the importance of further research into control measures for WNV, given its expansive host range and the role of various vertebrates in its transmission. It suggests that this information could lead to more effective strategies for managing and preventing WNV infections.

Cite This Article

APA
van der Meulen KM, Pensaert MB, Nauwynck HJ. (2005). West Nile virus in the vertebrate world. Arch Virol, 150(4), 637-657. https://doi.org/10.1007/s00705-004-0463-z

Publication

Archives of virology
ISSN: 0304-8608
NlmUniqueID: 7506870
Country: Austria
Language: English
Volume: 150
Issue: 4
Pages: 637-657

Researcher Affiliations

van der Meulen, K M
  • Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Pensaert, M B
    Nauwynck, H J

      MeSH Terms

      • Animal Diseases / virology
      • Animals
      • Horse Diseases / transmission
      • Horse Diseases / virology
      • Horses
      • Humans
      • Vertebrates
      • West Nile Fever / epidemiology
      • West Nile Fever / transmission
      • West Nile Fever / veterinary
      • West Nile virus

      Citations

      This article has been cited 50 times.
      1. Flores-Ferrer A, Suzán G, Waleckx E, Gourbière S. Assessing the risk of West Nile Virus seasonal outbreaks and its vector control in an urbanizing bird community: An integrative R0-modelling study in the city of Merida, Mexico.. PLoS Negl Trop Dis 2023 May;17(5):e0011340.
        doi: 10.1371/journal.pntd.0011340pubmed: 37253060google scholar: lookup
      2. Gothe LMR, Ganzenberg S, Ziegler U, Obiegala A, Lohmann KL, Sieg M, Vahlenkamp TW, Groschup MH, Hörügel U, Pfeffer M. Horses as Sentinels for the Circulation of Flaviviruses in Eastern-Central Germany.. Viruses 2023 Apr 30;15(5).
        doi: 10.3390/v15051108pubmed: 37243194google scholar: lookup
      3. Ndione MHD, Ndiaye EH, Faye M, Diagne MM, Diallo D, Diallo A, Sall AA, Loucoubar C, Faye O, Diallo M, Faye O, Barry MA, Fall G. Re-Introduction of West Nile Virus Lineage 1 in Senegal from Europe and Subsequent Circulation in Human and Mosquito Populations between 2012 and 2021.. Viruses 2022 Dec 6;14(12).
        doi: 10.3390/v14122720pubmed: 36560724google scholar: lookup
      4. Cavalleri JV, Korbacska-Kutasi O, Leblond A, Paillot R, Pusterla N, Steinmann E, Tomlinson J. European College of Equine Internal Medicine consensus statement on equine flaviviridae infections in Europe.. J Vet Intern Med 2022 Nov;36(6):1858-1871.
        doi: 10.1111/jvim.16581pubmed: 36367340google scholar: lookup
      5. Ganzenberg S, Sieg M, Ziegler U, Pfeffer M, Vahlenkamp TW, Hörügel U, Groschup MH, Lohmann KL. Seroprevalence and Risk Factors for Equine West Nile Virus Infections in Eastern Germany, 2020.. Viruses 2022 May 30;14(6).
        doi: 10.3390/v14061191pubmed: 35746662google scholar: lookup
      6. Bakos I, Mahdi M, Kardos L, Nagy A, Várkonyi I. Clinical Spectrum and CSF Findings in Patients with West-Nile Virus Infection, a Retrospective Cohort Review.. Diagnostics (Basel) 2022 Mar 25;12(4).
        doi: 10.3390/diagnostics12040805pubmed: 35453853google scholar: lookup
      7. García-Carrasco JM, Muñoz AR, Olivero J, Segura M, Real R. Mapping the Risk for West Nile Virus Transmission, Africa.. Emerg Infect Dis 2022 Apr;28(4):777-785.
        doi: 10.3201/eid2804.211103pubmed: 35318911google scholar: lookup
      8. Bergmann F, Trachsel DS, Stoeckle SD, Bernis Sierra J, Lübke S, Groschup MH, Gehlen H, Ziegler U. Seroepidemiological Survey of West Nile Virus Infections in Horses from Berlin/Brandenburg and North Rhine-Westphalia, Germany.. Viruses 2022 Jan 25;14(2).
        doi: 10.3390/v14020243pubmed: 35215837google scholar: lookup
      9. Schvartz G, Tirosh-Levy S, Bider S, Lublin A, Farnoushi Y, Erster O, Steinman A. West Nile Virus in Common Wild Avian Species in Israel.. Pathogens 2022 Jan 17;11(1).
        doi: 10.3390/pathogens11010107pubmed: 35056055google scholar: lookup
      10. Mencattelli G, Ndione MHD, Rosà R, Marini G, Diagne CT, Diagne MM, Fall G, Faye O, Diallo M, Faye O, Savini G, Rizzoli A. Epidemiology of West Nile virus in Africa: An underestimated threat.. PLoS Negl Trop Dis 2022 Jan;16(1):e0010075.
        doi: 10.1371/journal.pntd.0010075pubmed: 35007285google scholar: lookup
      11. Ferraguti M, Martínez-de la Puente J, Figuerola J. Ecological Effects on the Dynamics of West Nile Virus and Avian Plasmodium: The Importance of Mosquito Communities and Landscape.. Viruses 2021 Jun 23;13(7).
        doi: 10.3390/v13071208pubmed: 34201673google scholar: lookup
      12. Holicki CM, Michel F, Vasić A, Fast C, Eiden M, Răileanu C, Kampen H, Werner D, Groschup MH, Ziegler U. Pathogenicity of West Nile Virus Lineage 1 to German Poultry.. Vaccines (Basel) 2020 Sep 5;8(3).
        doi: 10.3390/vaccines8030507pubmed: 32899581google scholar: lookup
      13. Habarugira G, Suen WW, Hobson-Peters J, Hall RA, Bielefeldt-Ohmann H. West Nile Virus: An Update on Pathobiology, Epidemiology, Diagnostics, Control and "One Health" Implications.. Pathogens 2020 Jul 19;9(7).
        doi: 10.3390/pathogens9070589pubmed: 32707644google scholar: lookup
      14. Guo Y, Wang H, Xu S, Zhou H, Zhou C, Fu S, Cheng M, Li F, Deng Y, Li X, Wang H, Qin CF. Recovery and Genetic Characterization of a West Nile Virus Isolate from China.. Virol Sin 2021 Feb;36(1):113-121.
        doi: 10.1007/s12250-020-00246-xpubmed: 32632819google scholar: lookup
      15. Dächert C, Gladilin E, Binder M. Gene Expression Profiling of Different Huh7 Variants Reveals Novel Hepatitis C Virus Host Factors.. Viruses 2019 Dec 28;12(1).
        doi: 10.3390/v12010036pubmed: 31905685google scholar: lookup
      16. Stejskalova K, Janova E, Horecky C, Horecka E, Vaclavek P, Hubalek Z, Relling K, Cvanova M, D'Amico G, Mihalca AD, Modry D, Knoll A, Horin P. Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta.. Mol Biol Rep 2019 Aug;46(4):4453-4461.
        doi: 10.1007/s11033-019-04900-wpubmed: 31175514google scholar: lookup
      17. Eybpoosh S, Fazlalipour M, Baniasadi V, Pouriayevali MH, Sadeghi F, Ahmadi Vasmehjani A, Karbalaie Niya MH, Hewson R, Salehi-Vaziri M. Epidemiology of West Nile Virus in the Eastern Mediterranean region: A systematic review.. PLoS Negl Trop Dis 2019 Jan;13(1):e0007081.
        doi: 10.1371/journal.pntd.0007081pubmed: 30695031google scholar: lookup
      18. Talbot B, Caron-Lévesque M, Ardis M, Kryuchkov R, Kulkarni MA. Linking Bird and Mosquito Data to Assess Spatiotemporal West Nile Virus Risk in Humans.. Ecohealth 2019 Mar;16(1):70-81.
        doi: 10.1007/s10393-019-01393-8pubmed: 30673905google scholar: lookup
      19. Soltész Z, Erdélyi K, Bakonyi T, Barna M, Szentpáli-Gavallér K, Solt S, Horváth É, Palatitz P, Kotymán L, Dán Á, Papp L, Harnos A, Fehérvári P. West Nile virus host-vector-pathogen interactions in a colonial raptor.. Parasit Vectors 2017 Sep 29;10(1):449.
        doi: 10.1186/s13071-017-2394-zpubmed: 28962629google scholar: lookup
      20. Miller RS, Sweeney SJ, Slootmaker C, Grear DA, Di Salvo PA, Kiser D, Shwiff SA. Cross-species transmission potential between wild pigs, livestock, poultry, wildlife, and humans: implications for disease risk management in North America.. Sci Rep 2017 Aug 10;7(1):7821.
        doi: 10.1038/s41598-017-07336-zpubmed: 28798293google scholar: lookup
      21. Dahlin CR, Hughes DF, Meshaka WE Jr, Coleman C, Henning JD. Wild snakes harbor West Nile virus.. One Health 2016 Dec;2:136-138.
        doi: 10.1016/j.onehlt.2016.09.003pubmed: 28616487google scholar: lookup
      22. Tantely ML, Goodman SM, Rakotondranaivo T, Boyer S. Review of West Nile virus circulation and outbreak risk in Madagascar: Entomological and ornithological perspectives.. Parasite 2016;23:49.
        doi: 10.1051/parasite/2016058pubmed: 27849515google scholar: lookup
      23. Londono-Renteria B, Troupin A, Colpitts TM. Arbovirosis and potential transmission blocking vaccines.. Parasit Vectors 2016 Sep 23;9(1):516.
        doi: 10.1186/s13071-016-1802-0pubmed: 27664127google scholar: lookup
      24. Grinev A, Chancey C, Volkova E, Añez G, Heisey DA, Winkelman V, Foster GA, Williamson P, Stramer SL, Rios M. Genetic Variability of West Nile Virus in U.S. Blood Donors from the 2012 Epidemic Season.. PLoS Negl Trop Dis 2016 May;10(5):e0004717.
        doi: 10.1371/journal.pntd.0004717pubmed: 27182734google scholar: lookup
      25. Dridi M, Van Den Berg T, Lecollinet S, Lambrecht B. Evaluation of the pathogenicity of West Nile virus (WNV) lineage 2 strains in a SPF chicken model of infection: NS3-249Pro mutation is neither sufficient nor necessary for conferring virulence.. Vet Res 2015 Oct 30;46:130.
        doi: 10.1186/s13567-015-0257-1pubmed: 26518144google scholar: lookup
      26. Fischer D, Angenvoort J, Ziegler U, Fast C, Maier K, Chabierski S, Eiden M, Ulbert S, Groschup MH, Lierz M. DNA vaccines encoding the envelope protein of West Nile virus lineages 1 or 2 administered intramuscularly, via electroporation and with recombinant virus protein induce partial protection in large falcons (Falco spp.).. Vet Res 2015 Aug 17;46(1):87.
        doi: 10.1186/s13567-015-0220-1pubmed: 26282836google scholar: lookup
      27. Chancey C, Grinev A, Volkova E, Rios M. The global ecology and epidemiology of West Nile virus.. Biomed Res Int 2015;2015:376230.
        doi: 10.1155/2015/376230pubmed: 25866777google scholar: lookup
      28. Lim SM, Brault AC, van Amerongen G, Sewbalaksing VD, Osterhaus ADME, Martina BEE, Koraka P. Susceptibility of European jackdaws (Corvus monedula) to experimental infection with lineage 1 and 2 West Nile viruses.. J Gen Virol 2014 Jun;95(Pt 6):1320-1329.
        doi: 10.1099/vir.0.063651-0pubmed: 24671752google scholar: lookup
      29. Pérez-Ramírez E, Llorente F, Jiménez-Clavero MÁ. Experimental infections of wild birds with West Nile virus.. Viruses 2014 Feb 13;6(2):752-81.
        doi: 10.3390/v6020752pubmed: 24531334google scholar: lookup
      30. Ziegler U, Skrypnyk A, Keller M, Staubach C, Bezymennyi M, Damiani AM, Osterrieder N, Groschup MH. West nile virus antibody prevalence in horses of Ukraine.. Viruses 2013 Oct 4;5(10):2469-82.
        doi: 10.3390/v5102469pubmed: 24100889google scholar: lookup
      31. Cargnelutti JF, Brum MC, Weiblen R, Flores EF. Stable expression and potential use of west nile virus envelope glycoproteins preM/E as antigen in diagnostic tests.. Braz J Microbiol 2011 Jul;42(3):1161-6.
        doi: 10.1590/S1517-838220110003000040pubmed: 24031737google scholar: lookup
      32. Lazear HM, Pinto AK, Ramos HJ, Vick SC, Shrestha B, Suthar MS, Gale M Jr, Diamond MS. Pattern recognition receptor MDA5 modulates CD8+ T cell-dependent clearance of West Nile virus from the central nervous system.. J Virol 2013 Nov;87(21):11401-15.
        doi: 10.1128/JVI.01403-13pubmed: 23966390google scholar: lookup
      33. Ziegler U, Angenvoort J, Klaus C, Nagel-Kohl U, Sauerwald C, Thalheim S, Horner S, Braun B, Kenklies S, Tyczka J, Keller M, Groschup MH. Use of competition ELISA for monitoring of West Nile virus infections in horses in Germany.. Int J Environ Res Public Health 2013 Jul 24;10(8):3112-20.
        doi: 10.3390/ijerph10083112pubmed: 23887620google scholar: lookup
      34. Gamino V, Höfle U. Pathology and tissue tropism of natural West Nile virus infection in birds: a review.. Vet Res 2013 Jun 3;44(1):39.
        doi: 10.1186/1297-9716-44-39pubmed: 23731695google scholar: lookup
      35. Schmidt K, Keller M, Bader BL, Korytář T, Finke S, Ziegler U, Groschup MH. Integrins modulate the infection efficiency of West Nile virus into cells.. J Gen Virol 2013 Aug;94(Pt 8):1723-1733.
        doi: 10.1099/vir.0.052613-0pubmed: 23658209google scholar: lookup
      36. Hobson-Peters J. Approaches for the development of rapid serological assays for surveillance and diagnosis of infections caused by zoonotic flaviviruses of the Japanese encephalitis virus serocomplex.. J Biomed Biotechnol 2012;2012:379738.
        doi: 10.1155/2012/379738pubmed: 22570528google scholar: lookup
      37. Shiryaev SA, Strongin AY. Structural and functional parameters of the flaviviral protease: a promising antiviral drug target.. Future Virol 2010 Sep 1;5(5):593-606.
        doi: 10.2217/fvl.10.39pubmed: 21076642google scholar: lookup
      38. Cheng G, Cox J, Wang P, Krishnan MN, Dai J, Qian F, Anderson JF, Fikrig E. A C-type lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile virus infection of mosquitoes.. Cell 2010 Sep 3;142(5):714-25.
        doi: 10.1016/j.cell.2010.07.038pubmed: 20797779google scholar: lookup
      39. Kushawaha A, Jadonath S, Mobarakai N. West nile virus myocarditis causing a fatal arrhythmia: a case report.. Cases J 2009 May 27;2:7147.
        doi: 10.1186/1757-1626-2-7147pubmed: 19829922google scholar: lookup
      40. Pickett BE, Lefkowitz EJ. Recombination in West Nile Virus: minimal contribution to genomic diversity.. Virol J 2009 Oct 12;6:165.
        doi: 10.1186/1743-422X-6-165pubmed: 19821990google scholar: lookup
      41. Sidique S, Shiryaev SA, Ratnikov BI, Herath A, Su Y, Strongin AY, Cosford ND. Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase.. Bioorg Med Chem Lett 2009 Oct 1;19(19):5773-7.
        doi: 10.1016/j.bmcl.2009.07.150pubmed: 19703770google scholar: lookup
      42. Chisenhall DM, Mores CN. Diversification of West Nile virus in a subtropical region.. Virol J 2009 Jul 16;6:106.
        doi: 10.1186/1743-422X-6-106pubmed: 19607722google scholar: lookup
      43. Grinev A, Daniel S, Stramer S, Rossmann S, Caglioti S, Rios M. Genetic variability of West Nile virus in US blood donors, 2002-2005.. Emerg Infect Dis 2008 Mar;14(3):436-44.
        doi: 10.3201/eid1403.070463pubmed: 18325259google scholar: lookup
      44. Platt KB, Tucker BJ, Halbur PG, Tiawsirisup S, Blitvich BJ, Fabiosa FG, Bartholomay LC, Rowley WA. West Nile virus viremia in eastern chipmunks (Tamias striatus) sufficient for infecting different mosquitoes.. Emerg Infect Dis 2007 Jun;13(6):831-7.
        doi: 10.3201/eid1306.061008pubmed: 17553220google scholar: lookup
      45. Shiryaev SA, Ratnikov BI, Aleshin AE, Kozlov IA, Nelson NA, Lebl M, Smith JW, Liddington RC, Strongin AY. Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis.. J Virol 2007 May;81(9):4501-9.
        doi: 10.1128/JVI.02719-06pubmed: 17301157google scholar: lookup
      46. Shiryaev SA, Aleshin AE, Ratnikov BI, Smith JW, Liddington RC, Strongin AY. Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region.. Protein Expr Purif 2007 Apr;52(2):334-9.
        doi: 10.1016/j.pep.2006.11.009pubmed: 17189703google scholar: lookup
      47. Morales MA, Barrandeguy M, Fabbri C, Garcia JB, Vissani A, Trono K, Gutierrez G, Pigretti S, Menchaca H, Garrido N, Taylor N, Fernandez F, Levis S, Enría D. West Nile virus isolation from equines in Argentina, 2006.. Emerg Infect Dis 2006 Oct;12(10):1559-61.
        doi: 10.3201/eid1210.060852pubmed: 17176571google scholar: lookup
      48. Pugliese A, Beltramo T, Torre D. Emerging and re-emerging viral infections in Europe.. Cell Biochem Funct 2007 Jan-Feb;25(1):1-13.
        doi: 10.1002/cbf.1342pubmed: 16944546google scholar: lookup
      49. Bakonyi T, Ivanics E, Erdélyi K, Ursu K, Ferenczi E, Weissenböck H, Nowotny N. Lineage 1 and 2 strains of encephalitic West Nile virus, central Europe.. Emerg Infect Dis 2006 Apr;12(4):618-23.
        doi: 10.3201/eid1204.051379pubmed: 16704810google scholar: lookup
      50. Shiryaev SA, Ratnikov BI, Chekanov AV, Sikora S, Rozanov DV, Godzik A, Wang J, Smith JW, Huang Z, Lindberg I, Samuel MA, Diamond MS, Strongin AY. Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase.. Biochem J 2006 Jan 15;393(Pt 2):503-11.
        doi: 10.1042/BJ20051374pubmed: 16229682google scholar: lookup
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