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Reproduction in domestic animals = Zuchthygiene2020; 55(2); 200-208; doi: 10.1111/rda.13608

Whole-genome sequence analysis reveals candidate genomic footprints and genes associated with reproductive traits in Thoroughbred horse.

Abstract: The primary objective of most horse breeding operations was to maximize reproductive efficiency and minimize the cost of producing live foals. Here, we compared individual horses from the Thoroughbred population (n = 17), known as a horse breed with poor reproductive performance, with other six horse populations (n = 28), to detect genomic signatures of positive selection underlying of reproductive traits. A number of protein-coding genes with significant (p-value <.01) higher F values (616 genes) and a lower value for nucleotide diversity (π) (310 genes) were identified. The results of our study revealed some candidate genes such as IGFBP2, IGFBP5, GDF9, BRINP3 and GRID1 are possibly associated with functions influencing reproductive traits. These genes may have been under selection due to their essential roles in reproduction performance in horses. The candidate selected genes identified in this work should be of great interest for future research into genetic architecture of traits relevant to horse breeding programmes.
© 2019 Blackwell Verlag GmbH.
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Publication Date: 2020-01-10 PubMed ID: 31858623DOI: 10.1111/rda.13608Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study analyzes the entire genome sequencing of Thoroughbred horses and compares it with six other horse populations. The aim was to identify specific genetic markers that may improve reproductive traits, with findings revealing several candidate genes possibly influential to such traits.

Objective of the Study

  • The main goal of the study was to increase reproductive efficiency and reduce the cost of producing live foals in horse breeding operations.
  • The researchers aimed to understand the genetic markers linked to reproduction traits by analyzing the whole genome sequence of Thoroughbred horses, a breed known for its poor reproductive performance.

Methodology

  • The researchers compared individual horses from the Thoroughbred population with six other horse populations.
  • The intent was to identify genomic signatures of positive selection, indications of adaptive evolution that influence reproductive traits amongst the Thoroughbred population.

Results

  • The study identified several protein-coding genes with significantly higher F values and a lower value for nucleotide diversity that could be associated with reproductive traits.
  • Genes such as IGFBP2, IGFBP5, GDF9, BRINP3, and GRID1 were identified as possible candidates.
  • The researchers propose that these genes may have been under selection due to their critical roles in reproduction performance in horses.

Significance of the Study

  • The results of the study uncover potential genes that could have a significant influence on horse reproductive traits.
  • The findings could aid in understanding the mechanism of reproduction in horses, potentially improving reproductive efficiency and reducing the overall cost of producing live foals.
  • The identified genes of interest also pave the way for further research into the genetic architecture of traits relevant to horse breeding programmes.

Cite This Article

APA
Asadollahpour Nanaei H, Ayatollahi Mehrgardi A, Esmailizadeh A. (2020). Whole-genome sequence analysis reveals candidate genomic footprints and genes associated with reproductive traits in Thoroughbred horse. Reprod Domest Anim, 55(2), 200-208. https://doi.org/10.1111/rda.13608

Publication

Reproduction in domestic animals = Zuchthygiene
ISSN: 1439-0531
NlmUniqueID: 9015668
Country: Germany
Language: English
Volume: 55
Issue: 2
Pages: 200-208

Researcher Affiliations

Asadollahpour Nanaei, Hojjat
  • Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran.
Ayatollahi Mehrgardi, Ahmad
  • Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran.
Esmailizadeh, Ali
  • Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran.

MeSH Terms

  • Animals
  • Breeding
  • Female
  • Genome
  • Horses / genetics
  • Male
  • Phylogeny
  • Polymorphism, Single Nucleotide
  • Reproduction / genetics
  • Whole Genome Sequencing / veterinary

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