Whole-genome sequencing of Salmonella serovars isolated from diarrheic and non-diarrheic foals.
Abstract: spp. are important pathogens of foals, causing clinical enterocolitis and sepsis. We characterized the resistance, virulence, and stress response genes in isolates from foals with or without diarrhea. isolates ( = 23) recovered from fecal samples of 16 diarrheic and 7 non-diarrheic <1-y-old foals were subjected to whole-genome sequencing. The most common serovars detected in diarrheic foals were subsp. serovars Infantis and Minnesota. Multidrug resistance was observed in 9 of 23 isolates, with 8 of the 9 from diarrheic foals. All of the isolates contained at least 2 resistance genes, with most of the genes related to the multidrug efflux pump complex. Among the 9 isolates shown to be resistant to β-lactam antimicrobials, at least one antimicrobial resistance gene (ARG) related to the inactivation of these antimicrobials was observed (, , ). Among the 7 isolates resistant to the quinolone class, 3 contained ARGs (, ). The occurrence of multidrug-resistant isolates, particularly among foals with diarrhea, and the zoonotic potential of species, highlight the importance of implementing biosecurity measures on the studied farms.
Publication Date: 2025-02-10 PubMed ID: 39930357PubMed Central: PMC11811943DOI: 10.1177/10406387251316314Google Scholar: Lookup
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Cite This Article
APA
Basso RM, Cerri FM, Possebon FS, Braga PRC, Casas MRT, Oliveira-Filho JP, Araújo Júnior JP, Ribeiro MG, Arroyo LG, Borges AS.
(2025).
Whole-genome sequencing of Salmonella serovars isolated from diarrheic and non-diarrheic foals.
J Vet Diagn Invest, 37(2), 363-366.
https://doi.org/10.1177/10406387251316314 Publication
Researcher Affiliations
- School of Veterinary Medicine and Animal Science, Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil.
- School of Veterinary Medicine and Animal Science, Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil.
- Institute of Biotechnology, Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil.
- School of Veterinary Medicine and Animal Science, Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil.
- Adolfo Lutz Institute Bacteriology Division, Sao Paulo, Sao Paulo, Brazil.
- School of Veterinary Medicine and Animal Science, Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil.
- Institute of Biotechnology, Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil.
- School of Veterinary Medicine and Animal Science, Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil.
- Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
- School of Veterinary Medicine and Animal Science, Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil.
MeSH Terms
- Animals
- Horses
- Horse Diseases / microbiology
- Diarrhea / veterinary
- Diarrhea / microbiology
- Salmonella Infections, Animal / microbiology
- Whole Genome Sequencing / veterinary
- Salmonella / genetics
- Salmonella / drug effects
- Salmonella / pathogenicity
- Salmonella / isolation & purification
- Drug Resistance, Multiple, Bacterial / genetics
- Serogroup
- Anti-Bacterial Agents / pharmacology
- Genome, Bacterial
- Virulence / genetics
Conflict of Interest Statement
Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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Citations
This article has been cited 1 times.- Mileto I, Romano G, Gaiarsa S, Grassia G, Bagnarino J, Piralla A, Monzillo V, Cambieri P, Baldanti F, Corbella M. Whole genome sequencing as a reliable alternative for Salmonella serotyping: a comparative study with the gold-standard method.. Front Microbiol 2025;16:1685741.
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