Omneity® Pellets
All-In-One Vitamin & Mineral Pellet
Aging cell.
Publisher:
Blackwell Pub.,. Oxford, UK : Wiley-Blackwell
Frequency: Bimonthly
Country: England
Language: English
Author(s):
Anatomical Society of Great Britain and Ireland.
Start Year:2002 -
ISSN:
1474-9718 (Print)
1474-9726 (Electronic)
1474-9718 (Linking)
1474-9726 (Electronic)
1474-9718 (Linking)
Impact Factor
7.8
2023
| NLM ID: | 101130839 |
| (OCoLC): | 50677200 |
| LCCN: | 2002214719 |
| Classification: | W1 AG343W |
Immunolabelling and Micro-Computed Tomography Revealed Age-Related Alterations in 3D Microvasculature of Tendons. Tendon degeneration is common, and its risk increases with age both in humans and horses. Tendon regeneration and healing is limited due to inherent low cell density and vascularisation, and current treatments are insufficient as indicated by scar tissue formation and a high re-injury rate. The tendon vasculature plays a crucial role in tendon homeostasis, regeneration and healing, making it a potential therapeutic target. However, the effect of ageing on the tendon microvasculature is poorly understood. Here, we provide the first comprehensive characterisation of the tendon microvasculature. ...
Aging enhances a mechanically-induced reduction in tendon strength by an active process involving matrix metalloproteinase activity. Age-associated and degenerative loss of functional integrity in soft tissues develops from effects of cumulative and subtle changes in their extracellular matrix (ECM). The highly ordered tendon ECM provides the tissue with its tensile strength during loading. As age and exercise collide in the high incidence of tendinopathies, we hypothesized that aged tendons fail due to cumulative damage resulting from a combination of diminished matrix repair and fragmentation of ECM proteins induced by prolonged cyclical loading, and that this is an active cell-mediated process. We developed an equine ten...
