Aging cell.
Publisher:
Blackwell Pub.,. Oxford, UK : Wiley-Blackwell
Frequency: Bimonthly
Country: England
Language: English
Author(s):
Anatomical Society of Great Britain and Ireland.
Start Year:2002 -
ISSN:
1474-9718 (Print)
1474-9726 (Electronic)
1474-9718 (Linking)
1474-9726 (Electronic)
1474-9718 (Linking)
Impact Factor
7.8
2023
| NLM ID: | 101130839 |
| (OCoLC): | 50677200 |
| LCCN: | 2002214719 |
| Classification: | W1 AG343W |
Aging enhances a mechanically-induced reduction in tendon strength by an active process involving matrix metalloproteinase activity. Age-associated and degenerative loss of functional integrity in soft tissues develops from effects of cumulative and subtle changes in their extracellular matrix (ECM). The highly ordered tendon ECM provides the tissue with its tensile strength during loading. As age and exercise collide in the high incidence of tendinopathies, we hypothesized that aged tendons fail due to cumulative damage resulting from a combination of diminished matrix repair and fragmentation of ECM proteins induced by prolonged cyclical loading, and that this is an active cell-mediated process. We developed an equine ten...