Annals of internal medicine.
Publisher:
American College of Physicians.. Philadelphia, PA : American College of Physicians--American Society of Internal Medicine (2001)
Frequency: Monthly, 2021-
Country: United States
Language: English
Author(s):
American College of Physicians., American College of Physicians--American Society of Internal Medicine.
Start Year:1927 -
Identifiers
| ISSN: | 0003-4819 (Print) 1539-3704 (Electronic) 0003-4819 (Linking) |
| NLM ID: | 0372351 |
| (OCoLC): | 01481385 |
| (DNLM): | A34995000(s) |
| Coden: | AIMEAS |
| LCCN: | 43032966 |
| Classification: | W1 AN605 |
Heterologous antisera and antivenins are essential biologicals: perspectives on a worldwide crisis. Active immunization against infectious disease is important. However, much of our world faces poverty, social injustice, and warfare, all of which cause universal immunization to remain a distant dream. Agents that provide passive immunity thus remain essential biologicals. The most important of these are human or equine antisera against rabies, tetanus, diphtheria, and snake antivenins. Homologous products are either unavailable or unaffordable in places where they are needed the most. Less expensive heterologous (equine) antisera can be purified and are safe to use, but these antisera are al...
Lymphadenopathy-associated virus: from molecular biology to pathogenicity. Recent data indicate that the lymphadenopathy-associated virus (LAV) is morphologically similar to animal lentiviruses, such as equine infectious anemia and visna viruses. This finding, together with the cross-reactivity of the core proteins of LAV with those of the equine infectious anemia virus and a similarity in genome structure and biological properties, allows LAV to be placed in the retroviral subfamily of Lentivirinae. Molecular data indicate a high degree of genetic variation of the virus, especially in the envelope gene, which have important implications for the origin of the virus (...