Chirality.
Publisher:
Wiley
Frequency: 10 no. a year, 1998-
Country: United States
Language: English
Start Year:1989 -
ISSN:
0899-0042 (Print)
1520-636X (Electronic)
0899-0042 (Linking)
1520-636X (Electronic)
0899-0042 (Linking)
Impact Factor
2
2022
| NLM ID: | 8914261 |
| (DNLM): | SR0065568(s) |
| (OCoLC): | 18115575 |
| Coden: | CHRLEP |
| LCCN: | 89646700 |
| Classification: | W1 CH801 |
Development and validation of a chiral LC-MS method for the enantiomeric resolution of (+) and (-)-medetomidine in equine plasma by using polysaccharide-based chiral stationary phases. The detection and separation of medetomidine enantiomers from the complex biological matrices poses a great analytical challenge, especially in the field of forensic toxicology and pharmacology. Couple of researchers reported resolution of medetomidine using protein-based chiral columns, but the reported method is quiet challenging and tedious to be employed for routine analysis. This research paper reported a method that enables the enantio-separation of medetomidine by using polysaccharide cellulose chiral column. The use of chiralcel OJ-3R column was found to have the highest potential for ...
Structural investigations of stereoselective profen binding by equine and leporine serum albumins. Serum albumin, the most abundant transport protein of mammalian blood, interacts with various nonsteroidal anti-inflammatory drugs (NSAIDs) affecting their disposition, metabolism, and excretion. A big group of chiral NSAIDs transported by albumin, profens, is created by derivatives of 2-arylpropionic acid. The chiral center in the structures of profens is adjacent to the carboxylate moiety and often determines different pharmacological properties of profen enantiomers. This study describes crystal structures of two albumins, isolated from equine and leporine serum, in complexes with three pro...