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Frontiers in immunology.

Periodical
Allergy and Immunology
Immune System Diseases
Immune System Phenomena
Publisher:
Frontiers Research Foundation]
Country: Switzerland
Language: English
Start Year:2010 -
ISSN:
1664-3224 (Electronic)
1664-3224 (Linking)
Impact Factor
7.3
2022
NLM ID:101560960
(OCoLC):756441628
LCCN:2012243079
Extracellular Vesicles in Joint Disease and Therapy.
Frontiers in immunology    November 12, 2018   Volume 9 2575 doi: 10.3389/fimmu.2018.02575
Boere J, Malda J, van de Lest CHA, van Weeren PR, Wauben MHM.The use of extracellular vesicles (EVs) as a potential therapy is currently explored for different disease areas. When it comes to the treatment of joint diseases this approach is still in its infancy. As in joint diseases both inflammation and the associated articular tissue destruction are important factors, both the immune-suppressive and the regenerative properties of EVs are potentially advantageous characteristics for future therapy. There is, however, only limited knowledge on the basic features, such as numerical profile and function, of EVs in joint articular tissues in general and th...
Utility of a Mouse Model of Osteoarthritis to Demonstrate Cartilage Protection by IFNγ-Primed Equine Mesenchymal Stem Cells.
Frontiers in immunology    September 27, 2016   Volume 7 392 doi: 10.3389/fimmu.2016.00392
Maumus M, Roussignol G, Toupet K, Penarier G, Bentz I, Teixeira S, Oustric D, Jung M, Lepage O, Steinberg R, Jorgensen C, Noel D.Mesenchymal stem cells isolated from adipose tissue (ASC) have been shown to influence the course of osteoarthritis (OA) in different animal models and are promising in veterinary medicine for horses involved in competitive sport. The aim of this study was to characterize equine ASCs (eASCs) and investigate the role of interferon-gamma (IFNγ)-priming on their therapeutic effect in a murine model of OA, which could be relevant to equine OA. Methods: ASC were isolated from subcutaneous fat. Expression of specific markers was tested by cytometry and RT-qPCR. Differentiation potential was evaluat...
Neutrophil NETs in reproduction: from infertility to preeclampsia and the possibility of fetal loss.
Frontiers in immunology    November 27, 2012   Volume 3 362 doi: 10.3389/fimmu.2012.00362
Hahn S, Giaglis S, Hoesli I, Hasler P.The intention of this review is to provide an overview of the potential role of neutrophil extracellular traps (NETs) in mammalian reproduction. Neutrophil NETs appear to be involved in various stages of the reproductive cycle, starting with fertility and possibly ending with fetal loss. The first suggestion that NETs may play a role in pregnancy-related disorders was in preeclampsia, where vast numbers were detected in the intervillous space of affected placentae. The induction of NETosis involved an auto-inflammatory component, mediated by the increased release of placental micro-debris in p...