English
French
Hepatology : official journal of the American Association for the Study of Liver Diseases.
Publisher:
Williams & Wilkins,. [Philadelphia] : Wolters Kluwer Health, Inc. (2023)
Frequency: Monthly
Country: United States
Language: English
Start Year:1981 -
ISSN:
0270-9139 (Print)
1527-3350 (Electronic)
0270-9139 (Linking)
1527-3350 (Electronic)
0270-9139 (Linking)
Impact Factor
17.298
2022
| NLM ID: | 8302946 |
| (DNLM): | H11325000(s) |
| (OCoLC): | 06848614 |
| Coden: | HPTLD9 |
| LCCN: | 81641046 |
| Classification: | W1 HE912 |
Pathogenesis, MicroRNA-122 Gene-Regulation, and Protective Immune Responses After Acute Equine Hepacivirus Infection. Equine hepacivirus (EqHV) is phylogenetically the closest relative of HCV and shares genome organization, hepatotropism, transient or persistent infection outcome, and the ability to cause hepatitis. Thus, EqHV studies are important to understand equine liver disease and further as an outbred surrogate animal model for HCV pathogenesis and protective immune responses. Here, we aimed to characterize the course of EqHV infection and associated protective immune responses. Seven horses were experimentally inoculated with EqHV, monitored for 6 months, and rechallenged with the same and, subsequen...
Experimental transmission of equine hepacivirus in horses as a model for hepatitis C virus. Equine hepacivirus (EHCV; nonprimate hepacivirus) is a hepatotropic member of the Flaviviridae family that infects horses. Although EHCV is the closest known relative to hepatitis C virus (HCV), its complete replication kinetics in vivo have not been described, and direct evidence that it causes hepatitis has been lacking. In this study, we detected EHCV in 2 horses that developed post-transfusion hepatitis. Plasma and serum from these horses were used to experimentally transmit EHCV to 4 young adult Arabian horses, two 1-month-old foals (1 Arabian and 1 Arabian-pony cross), and 2 foals (1 Ara...
