Journal of mathematical biology.
Publisher:
Springer-Verlag.. Berlin : Springer Verlag
Frequency: Monthly, 1998-
Country: Germany
Language: English
Author(s):
European Society for Mathematical and Theoretical Biology.
Start Year:1974 -
ISSN:
0303-6812 (Print)
1432-1416 (Electronic)
0303-6812 (Linking)
1432-1416 (Electronic)
0303-6812 (Linking)
Impact Factor
1.9
2022
| NLM ID: | 7502105 |
| (DNLM): | J28340000(s) |
| (OCoLC): | 01794831 |
| Coden: | JMBLAJ |
| LCCN: | 74645888 |
| Classification: | W1 JO748SE |
The evolutionary consequences of alternative types of imperfect vaccines. The emergence and spread of mutant pathogens that evade the effects of prophylactic interventions, including vaccines, threatens our ability to control infectious diseases globally. Imperfect vaccines (e.g. those used against influenza), while not providing life-long immunity, confer protection by reducing a range of pathogen life-history characteristics; conversely, mutant pathogens can gain an advantage by restoring the same range of traits in vaccinated hosts. Using an SEIR model motivated by equine influenza, we investigate the evolutionary consequences of alternative types of imperfect va...