English
French
Respirology : official journal of the Asian Pacific Society of Respirology.
Publisher:
Blackwell Science,
Frequency: Eight no. a year, 2009-
Country: Australia
Language: English
Author(s):
Asian Pacific Society of Respirology.
Start Year:1996 -
ISSN:
1323-7799 (Print)
1440-1843 (Electronic)
1323-7799 (Linking)
1440-1843 (Electronic)
1323-7799 (Linking)
Impact Factor
6.9
2022
| NLM ID: | 9616368 |
| (DNLM): | SR0088904(s) |
| (OCoLC): | 35924110 |
| Classification: | W1 RE248NG |
Tamoxifen as a new therapeutic tool for neutrophilic lung inflammation. Neutrophilic asthma is an important disease subgroup, including patients with severe phenotypes and erratic responses to standard treatments. Tamoxifen (TX), a selective estrogen receptor modulator (SERM) used as treatment of human breast cancer, has been shown to induce early apoptosis of equine blood and bronchoalveolar lavage fluid (BALF) neutrophils in vitro. Equine recurrent airway obstruction (RAO) is a naturally occurring neutrophilic condition, closely related with human asthma. Our purpose was to investigate the therapeutic potential of tamoxifen in horses with neutrophilic lung infla...
Heaves, an asthma-like disease of horses. Animal models have been developed to investigate specific components of asthmatic airway inflammation, hyper-responsiveness or remodelling. However, all of these aspects are rarely observed in the same animal. Heaves is a naturally occurring disease of horses that combines these features. It is characterized by stable dust-induced inflammation, bronchospasm and remodelling. The evaluation of horses during well-controlled natural antigen exposure and avoidance in experimental settings allows the study of disease mechanisms in the asymptomatic and symptomatic stages, an approach rarely feasible ...
