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Topic:Disease
The study of diseases in horses encompasses a wide range of conditions affecting equine health, including infectious diseases, metabolic disorders, and genetic abnormalities. These diseases can impact various systems within the horse, such as respiratory, gastrointestinal, and musculoskeletal systems, and can lead to significant health challenges. Research in this area focuses on understanding the pathophysiology, diagnosis, prevention, and treatment of equine diseases. Common diseases studied include equine influenza, equine herpesvirus, and laminitis. This page provides access to peer-reviewed research studies and scholarly articles that explore the etiology, clinical presentation, and management strategies of diseases in horses, contributing to the advancement of equine veterinary medicine.
Colic in a mare caused by a colonic neurofibroma. A 16 year old Thoroughbred mare was presented to the Ontario Veterinary College because of an acute episode of colic. An exploratory laparotomy was performed and a neurofibroma was identified and successfully removed from the small colon. The clinical and pathological features of this case are discussed.
Chlamydia psittaci induced pneumonia in a horse. An agent lethal to embryonated chicken eggs was isolated from lung tissues of a quarter horse mare with a fatal respiratory disease. The lesions induced in embryonated chicken eggs, the tinctoral properties, the ultrastructural morphology, the resistance of the organism to sodium sulfadiazine, and the presence of a chlamydial complement fixing antigen, identify this isolate as a member of the family Chlamydiaceae and suggest the agent to be Chlamydia psittaci. Two Shetland ponies experimentally infected with the isolated agent developed subclinical infection as demonstrated by an increase in c...
Antigenic properties of some equine influenza viruses. The antigenic relationships between the haemagglutinins of five A/equine-1 viruses and between six A/equine-2 viruses were examined using post-infection ferret and immunized pony sera. Similar results were obtained with sera from both species for the A/equine-1 viruses and these confirmed minor antigenic differences between the prototype A/Prague 1/56 virus and viruses isolated in England in 1973 and 1977. Considerable antigenic differences were found between five of the A/equine-2 viruses, using ferret sera, but these differences were less evident using pony sera. The response of ponies to th...
Results of concurrent bacteriological and cytological examinations of the endometrium of mares in routine stud farm practice 1978-1981. The results of 4024 concurrent endometrial swab and smear tests taken from maiden, barren and post-parturient mares during early oestrus, before coitus demonstrated the practical value of these tests in routine stud farm practice. The use of cytological examinations provided a more direct diagnostic test for acute endometritis and this increased the accuracy of interpretation of the bacteriological findings.
Factors affecting testis weight in normal and cryptorchid horses. Testes were collected from normal and cryptorchid horses of a variety of breeds and ages and weighed after dissection from the epididymis. Scrotal testes grow little until the second winter of life and little thereafter, although a nearly mature body weight is reached by the end of the first winter. Scrotal testes in unilateral cryptorchids tend to be larger than those of normal stallions, sometimes exceedingly so, although occasional small scrotal testes are recorded. Inguinal testes show some tendency to grow during the second winter but the data are difficult to analyse beyond that age beca...
Aneurysmal bone cyst in the horse. An aneurysmal bone cyst was diagnosed in the distal metaphysis of Mt3 in a 9-month-old-Quarter Horse colt. The lesion developed between the fifth and ninth month of life and clinically appeared as a non-painful swelling which did not cause a lameness. Radiographs of the lesion showed expansion of the cortex and incomplete septa of new bone extending from the cortex into surrounding soft tissue. Surgical intervention revealed a blood filled cavity. The animal died during the immediate post-surgical period. Histopathologic evaluation of the lesion was performed.
Bronchoscopy and cytological examination of bronchial secretions of horses with chronic obstructive pulmonary disease (COPD). On the basis of cytological similarities in chronic obstructive disease (COPD) in human beings and in horses during 1981 a total number of 144 horses with COPD were examined. Bronchial secretions were taken under endoscopic control and stained with a modified Hansel staining procedure. Whereas 26 horses did not exhibit signs of allergic reactions cytologically and 94 horses showed low amounts of eosinocytes and/or mast cells in their secretion; only the secretions of 24 horses (16,67%) were characterized by fairly high contents of these allergy associated cells and low numbers of neutrophilic ...
Equine immunology 2: immunopharmacology–biochemical basis of hypersensitivity. In general, 4 types of hypersensitivity reactions can be defined according to their immunological basis and clinical appearance. The differing mechanisms of these responses are described with particular reference to chemical mediators which through their pharmacological actions contribute to the clinical manifestations of hypersensitivity. Chemical mediators may exert their influence locally or systemically through their action on effector, tissues or organs and in addition, may be involved in the recruitment of cells of specific type to the site of the reaction. The possible role of these med...
[Maduromycotic mycetoma in a horse]. A case of maduromycotic mycetoma (eumycetoma) in seven years old draught horse is described. The disease was localized in anal region and healed after surgical treatment. Attention is drawn to the necessity of distinguishing three types of mycosis in horses, characterized by the origin of tumor lesions - mycetomas, hyphomycosis and entomophthoromycosis - and information was gathered on their etiology and geographical occurrence. On the basis of the morphology of fungal elements traced in inflammated changed tissues and with regard to the existing findings on the origin of eumycetoma in animals...
A summary of antibody titration experiments in some animal species treated with ERA vaccine and an inactivated rabies vaccine. The results of antibody titrations in different animal species vaccinated against rabies are reported. The following points are considered: (1) antibody titration may be used to detect an immunity status in dogs, (2) equines should be vaccinated in infected areas, (3) experiments in progress are comparing ERA vaccine and an inactivated vaccine in bovines, and (4) the vaccination of fallow deer (Dama dama) and moufflons (Ovis ammon musimon) produced results suggesting an extension of the experiment with the purpose of vaccinating wild ruminants whenever possible.
Immunity to and immunotherapy for Rhodococcus equi. Immune responses to Rhodococcus equi were assayed in mares and foals on 7 studs in south-eastern Australia using skin test reactivity to the intradermal injection of culture filtrate and an indirect fluorescent antibody test. The prevalence of positive skin-test reactions did not differ between studs with a history of R. equi disease and those without but there were more mares with high antibody titres on studs with a disease history. A leucocyte extract prepared from mares that were skin-test positive was evaluated for its ability to protect foals exposed to experimental or natural challenge:...
Observations on vascular accidents in the central nervous system of neonatal foals. A technique for the subarachnoid perfusion-fixation of the central nervous system was developed to help identify various significant vascular accidents (SVAs) in the central nervous system (CNS) of 24 neonatal foals submitted for necropsy. SVAs, comprising subarachnoid, parenchymal and nerve root haemorrhages, and oedema and necrosis, occurred in 17 foals, more frequently in the spinal cord than the brain. They occurred as frequently in premature foals as in those born at full term, in foals born dead as in foals born alive, and in foals born following dystocia with an assisted delivery as in ...
Indirect hemagglutination test in equine infectious anemia. An indirect hemagglutination was developed for the diagnosis of equine infectious anemia using sheep red blood cells coated with group specific virus antigen which had been highly purified by affinity chromatography. The presence of indirect hemagglutination antibodies was demonstrated in horses with equine infectious anemia since the cells were specifically agglutinated by all the serum samples obtained from experimentally infected horses. Antibodies appeared within 35 days after inoculation, and development of which coincided well with that of precipitating and complement fixing antibodies. ...
Lymphocyte stimulation response in horses against phytohaemagglutinin and M protein of Streptococcus equi using whole blood. Lymphocyte stimulation was observed in whole equine blood in the presence of phytohaemagglutinin and M protein extracted from a typical strain of Streptococcus equi. Blood samples were collected from several healthy horses and horse and pony foals and cultured in vitro with varying concentrations of phytohaemagglutinin and M protein for several days. Phytohaemagglutinin was found to induce lymphocyte stimulation in these animals. Highest mean stimulation indices in horse foals (49.3 +/- 24.4) and pony foals (54.7 +/- 32.0) were observed with 0.625 and 1.25 micrograms/mL phytohaemagglutinin, re...
Effect of ovarian hormones on the phagocytic response of ovariectomized mares. The reaction between ovarian hormones and experimental uterine infection (Streptococcus zooepidemicus) was investigated in 3 groups, each containing 6 ovariectomized mares. Group 1 served as controls ('anoestrus'), Group 2 mares were injected with oestrogen ('oestrus') and Group 3 with progesterone ('dioestrus') over a period of 5 weeks. All mares received an intrauterine inoculation of the bacteria 1 week after the start of hormonal treatment, and the results of the challenge were examined by endometrial biopsy and swabs once weekly. At the end of Week 1 no bacteria were recovered from the ma...
Uterine prostaglandin F metabolite production in relation to glucose availability in late pregnancy and a possible influence of diet on time of delivery in the mare. The production of uterine PGFM during different dietary states has been investigated in pregnant mares in late gestation. Arterial and uterine venous plasma concentrations of PGFM rose when food was withdrawn for 12-30 h and the V-A difference widened significantly. There was an inverse correlation between the rise in PGFM and the fall in plasma glucose during a fast, and a significant decrease in the A-V plasma glucose differences across the uterus. Plasma PGFM and free fatty acid concentrations before and during food withdrawal were also correlated but no uterine A-V difference in free fatty...
Ovarian disorders: clinical and morphological observations in 30 mares. A five year prospective study of equine ovarian problems requiring surgical correction was undertaken at the Ontario Veterinary College. Thirty mares were studied, of which 14 had granulosa cell tumors, six were with anovulatory persistent follicular "structures", five had ovarian hemotoma, two presented ovarian hypoplasia and one each of ovarian dysgerminoma, teratoma and abscessation. The clinical signs manifested by the affected animals were varied. The affected ovaries were removed via flank or midline laparotomy or through colpotomy. Their morphology was studied and representative portion...
