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Topic:Disease
The study of diseases in horses encompasses a wide range of conditions affecting equine health, including infectious diseases, metabolic disorders, and genetic abnormalities. These diseases can impact various systems within the horse, such as respiratory, gastrointestinal, and musculoskeletal systems, and can lead to significant health challenges. Research in this area focuses on understanding the pathophysiology, diagnosis, prevention, and treatment of equine diseases. Common diseases studied include equine influenza, equine herpesvirus, and laminitis. This page provides access to peer-reviewed research studies and scholarly articles that explore the etiology, clinical presentation, and management strategies of diseases in horses, contributing to the advancement of equine veterinary medicine.
Interaction of horse plasma antithrombin III and alpha 1-proteinase inhibitor with some serine proteinases. Antithrombin III and alpha 1-proteinase inhibitor isolated simultaneously from horse citrated plasma were tested for inhibitory activity against bovine trypsin and chymotrypsin, as well as elastase-like neutral proteinases from horse leucocytes. The stoichiometry of reaction and kinetic parameters (kass, Ko) were estimated and related to the protein pattern obtained after exposure of these proteinases to horse inhibitors as analyzed by polyacrylamide gel electrophoresis (PAGE and PAGE-SDS). As shown by fast reaction rates and low values of dissociation constants the two inhibitors effectively ...
A survey of post mortem findings in 480 horses 1958 to 1980: (1) causes of death. The causes of death recorded in 480 consecutive post mortem examinations of horses performed at the department of pathology, Veterinary Field Station, University of Liverpool, between February 1958 and February 1980, are reported. The alimentary, locomotor and nervous systems were those most frequently diseased. The most common specific entities were those associated with grass sickness, fractures and endoparasitism.
Concentration of serum transferrin in sick horses and its relationship to serum albumin content. Studies of transferrin (Tf) concentration in sera of sick horses were carried out using Mancini’s immunodiffusion technique. Relative values against a chosen reference serum were determined for a total of 112 horses. Horses with acute infections had Tf values significantly below the normal. The lowest individual Tf value in this group (46%) was found in a six-months-old foal with temperature 41°C and watery diarrhoea. Horses suffering from acute laminitis also had decreased Tf values. The lowest value in the whole material (45%) was found in a horse belonging to this group. There was a posi...
[Inactivated vaccines against rhinopneumonitis in horses]. Attempts were made to produce inactivated vaccines against horse Herpes virus 1, using various inactivating agents and adjuvants, Best results were obtained with vaccine No 3 (glutaraldehide inactivator and "CTC" adjuvant). Used were two strains of the virus (St. Karaja and Varna). isolated in this country in cell cultures of a sucking pig kidney. Vaccine No 3 showed good immunogenic properties. Its application resulted in the full cease of abortions and respiratory diseases on the base of infection with the horse Herpes virus 1. The vaccination protects newborn colts from rhinopneumonitis if ...
Melioidosis with acute meningoencephalomyelitis in a horse. A case of acute meningoencephalomyelitis caused by infection with Pseudomonas pseudomallei is described. Clinically there was inability to stand, opisthotonus, facial paralysis and nystagmus, rapidly progressing to violent struggling. Gross examination revealed malacia and haemorrhage in the medulla oblongata and adjacent spinal cord. Microscopically there were disseminated focal neutrophilic accumulations in affected areas, perivascular cuffing with mononuclear cells and lymphocytes and marked oedema. Intracellular bacteria were identified in sections stained by the Giemsa method.
[A serological study of the contagious equine metritis: comparison between indirect immunofluorescence, slow agglutination and complement fixation techniques (author’s transl)]. Serological response of pony mares to contagious equine metritis is studied comparing three techniques: slow agglutination, complement fixation and indirect immunofluorescence. Sera were taken from pony mares vaccinated with a heat inactivated suspension of Haemophilus equigenitalis, from experimentally-infected pony mares and from healthy horses. All three reactions detected antibodies in vaccinated and infected animals. The highest titers are observed with vaccinated mares. Titers are low in infected animals. Antibodies detected by indirect immunofluorescence appeared sooner and persisted lo...
Equine congenital cutaneous papillomatosis: a report of 5 cases. Four cases of equine congenital cutaneous papillomatosis were found during a review of 555 cutaneous tumours received at the pathology department, Ontario Veterinary College, during a 10-year period. A fifth case received after that period was also included. Two of the tumours were found in Thoroughbreds, one in a Standardbred, one in an Arabian and in one case the breed was not specified. The anatomical locations were the rib cage, head, hind leg and 2 on the forehead.
Propagation of equine infectious anemia virus in horse cell cultures. The Wyoming strain of equine infectious anemia virus was adapted to cell cultures by 7 passages in horse leukocytes and 14 passages in fetal equine dermal and kidney cells. The virus was made evident by electron microscopy and immunodiffusion tests with antigens prepared from culture fluids.
The serological response of foals to vaccination against strangles. A group of 100 foals was given either a commercial bacterin or an autogenous vaccine consisting of whole cells and an acid extract of Streptococcus equi. During the study, some of the foals developed clinical strangles. Various sets of sera were collected from these foals prevaccination, during vaccination, postvaccination and postinfection. The serological response of these foals was measured by passive haemagglutination and long chain tests. In foals which remained healthy, the highest titres were reached within one to two months postvaccination with a passive haemagglutination 10 x log2 mea...
Ischaemic myocardial fibrosis and aortic strongylosis in the horse. The hearts and aortas of 2076 unselected horses of all ages were examined immediately after slaughter. Focal zones of fibrosis, observed in the myocardium of 14.3 per cent of hearts examined, were found in both atria and ventricles and were unrelated to age. Microscopically the majority of lesions involved myocardial fibre lysis and replacement fibrosis, although acute infarction was present in some cases. Intramyocardial arterioles in or adjacent to the lesions exhibited occlusive arteriosclerotic changes whereas those elsewhere remained patent. The evidence strongly suggests that the myocard...
Susceptibility of Haemophilus equigenitalis, the causal agent of contagious equine metritis, to 31 antimicrobial agents. The minimal inhibitory concentrations of 31 antimicrobial agents were determined for 99 isolates of Haemophilus equigenitalis by the agar dilution method. All the isolates showed good susceptibility to 26 antimicrobial agents tests, minimal inhibitory concentrations of which were less than 3.13 micrograms/ml for more than 90% of the isolates. Of these agents, 4 macrolides (erythromycin, oleandomycin, kitasamycin, tylosin), 3 tetracyclines (tetracycline, chlortetracycline, oxytetracycline), 1 peptide (colistin), 1 penicillin (ampicillin) and 1 pleuromutilin (tiamulin) were the most active agent...
Hemagglutination of several strains of equine infectious anemia virus. Six strains of equine infectious anemia (EIA) virus propagated in equine leukocyte cultures were found to agglutinate horse erythrocytes. Concentrated virus material containing about 20 units of complement fixation (CF) titer showed hemagglutinating (HA) titers ranging from 4 to 8 units. The HA activity remained stable after ether treatment and was reduced by trypsin, formaldehyde and KIO4. Cesium chloride equilibrium density gradient centrifugation revealed two populations of hemagglutinin, one in the density range of 1.15-1.16 g/ml coinciding with a peak of CF antigen and the other at round ...
A survey of post mortem findings in 480 horses 1958 to 1980: (2) disease processes not directly related to the cause of death. Disease processes not directly related to the cause of death recorded in 480 consecutive post mortem examinations of horses performed at the department of pathology, Veterinary Field Station, University of Liverpool, between February 1958 and February 1980 are reported. The alimentary, cardiovascular, respiratory and locomotor systems were those most frequently diseased. The most common specific entities were those associated with endoparasitism and its associated vascular lesions, pneumonia and fractures.
Distribution of ribonucleic acid coliphages in animals. To determine the distribution pattern of ribonucleic acid (RNA) coliphages (classified by serological groups I through IV) in animal sources, we isolated RNA phages from (i) feces samples from domestic animals (cows, pigs, horses, and fowls), some other animals in a zoological garden, and humans, (ii) the gastrointestinal contents of cows and pigs, and (iii) sewage samples from treatment plants in slaughter houses. These samples were then analyzed serologically. The concentration of RNA phages in the first and second kinds of material was fairly low (10 to 10(3) plaque-forming units per origin...
Lymphocyte transformation test in veterinary clinical immunology. Lymphocyte transformation test is a powerful tool in laboratory testing of immunologic competence of animals. The impaired function of the lymphocytes or presence of mitogenesis suppressing factors in the patient serum were detected by comparing lymphocyte transformation (expressed as thymidine incorporation) obtained in media containing either autologous, homologous, or fetal calf serum additions. Most valuable results were obtained by using at least two, preferably three, different phytomitogens: concanavalin A (Con A), pokeweed mitogen (PWM), and phytohemagglutinin (PHA) at optimal concentr...
Determination of plasma fibrinogen concentration in the horse. The microhematocrit heat-precipitation methods of Millar et al (1971) and Schalm et al (1975) were compared with the reference clottable protein method of Ratnoff and Menzie (1951) in the measurement of plasma fibrinogen concentration in horses. The millar et al method was more precise and accurate and showed better positive correlation with the reference method than did the Schalm et al method. There was no significant difference in the plasma fibrinogen concentration between healthy Thoroughbreds and healthy horses of other breeds. Horses with bacterial pneumonia and abscesses had significan...
[Disseminated intravascular coagulation in colitis X. Coincidence or part of the syndrome? (author’s transl)]. The course run by the disease is described in a horse which showed the symptom complex of colitis X following treatment with oxytetracycline. Disseminated intravascular coagulation was also observed in this horse. The possibility of disseminated intravascular coagulation being part of colitis X is discussed.
[Zinc poisoning in a foal (author’s transl)]. The clinical and pathomorfological symptoms of a two month's zinc-overload in a foal are described. After an exposure of about two weeks symptoms of unthriftness and increasing stiffness develope. The stiffness is caused by severe intra-articular damage.
