Topic:Metoprolol
Metoprolol is a beta-blocker that is primarily used to manage cardiac conditions in humans, such as hypertension and arrhythmias. In equine medicine, its use is less common but may be explored for similar cardiovascular issues in horses. Metoprolol functions by blocking beta-adrenergic receptors, which can lead to a decrease in heart rate and blood pressure. This page compiles peer-reviewed research studies and scholarly articles that investigate the pharmacokinetics, effects, and potential applications of metoprolol in equine health. It also includes studies on dosage, administration routes, and any observed side effects in horses.
Screening and confirmatory analysis of beta-agonists, beta-antagonists and their metabolites in horse urine by capillary gas chromatography-mass spectrometry. A method for the screening and confirmatory analysis of beta-agonists and -antagonists in equine urine is described. Following initial enzymic hydrolysis, the basic drugs and metabolites are extracted using Clean Screen DAU or Bond Elut Certify cartridges, and analysed as their trimethylsilyl ether or 2-(dimethyl) silamorpholine derivatives by capillary gas chromatography-mass spectrometry. The method proved to be very sensitive and selective for basic drugs. After administration of therapeutic doses of propranolol, metoprolol, timolol, isoxsuprine and clenbuterol to thoroughbred horses, the p...
Metabolic and physiological effects of adrenoceptor agonists and antagonists in the horse. In the horse the effect of the adrenergenic agonists adrenaline, phenylephrine and salbutamol on haematocrit, plasma free fatty acid, glycerol and lactate levels were investigated. Effects on heart rate, sweating and muscle tremor were also studied. The effects of administration of the adrenoceptor antagonists propranolol, metoprolol, H35/25 and acepromazine on adrenaline-induced changes were examined. The results obtained with these agonists and antagonists suggest that the lipolysis and hyperglycaemia are mediated via beta-adrenoceptors. It appears that both beta1 and beta2 subtypes are invo...
The actions of the beta-adrenoceptor blocking agents propranolol and metoprolol in the maximally exercised horse. The effects of two beta-adrenoceptor antagonists, propranolol (0.2 mg/kg) and metoprolol (0.2 mg/kg) on some physiological and metabolic changes produced by maximal exercise in the horse were investigated. Both drugs reduced the elevation in heart rate seen immediately following exercise and reduced performance as was seen by the increased time taken to perform each gallop. The rise in plasma glucose, glycerol and lactate, and the fall in blood pH seen following exercise were attenuated by both drugs. However, a greater increase in plasma free fatty acids occurred. Exercise produced a nine- to...