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Topic:Prognosis

Prognosis in horses refers to the prediction of the likely outcome or course of a disease or injury in equine patients. It involves assessing various factors such as the nature and severity of the condition, the horse's overall health, and response to treatment. Prognostic evaluations help veterinarians and horse owners make informed decisions regarding treatment options, management strategies, and potential recovery. The process often incorporates clinical assessments, diagnostic tools, and historical data to estimate the chances of recovery or progression. This page compiles peer-reviewed research studies and scholarly articles that explore methodologies, factors influencing prognostic outcomes, and the implications of prognostic evaluations in equine veterinary practice.
Adverse effects of a proposed equine sublethal endotoxin model.
The Onderstepoort journal of veterinary research    September 1, 1989   Volume 56, Issue 3 207-209 
Stadler P, Van Amstel SR.Commercially available Escherichia coli 055: B5 lipopolysaccharide was administered intravenously experimentally at a dosage of 10 micrograms/kg to 2 horses. Various clinical and clinico-pathological parameters were monitored before and after the endotoxin administration. Because of a hopeless prognosis, and for humane reasons, euthanasia was applied on both horses 6 h after administration. Values recorded for the different parameters, including the blood lactate level, were consistent with a lethal condition. It would appear that an intravenous dose of 10 micrograms/kg of endotoxin is potenti...
Corrections for prognostic index equation.
American journal of veterinary research    August 1, 1989   Volume 50, Issue 8 1429 
Fischer AT.No abstract available
Prevention of large colon displacements and volvulus.
The Veterinary clinics of North America. Equine practice    August 1, 1989   Volume 5, Issue 2 395-405 doi: 10.1016/s0749-0739(17)30596-5
Markel MD.Results of these studies have demonstrated that colopexy of the left large colon to the abdominal wall is a relatively simple and quick procedure that is permanent 1 year after surgery. The technique does not appear to be associated with long-term weight loss or abdominal pain after surgery. It has been used in pregnant mares, both experimentally and clinically, without apparent complications. In addition, horses used for pleasure-riding and show hunting have returned to performance and have not had complications. Large colon resection is a useful technique, especially for animals with strangu...
Equine interferons following exposure to equid herpesvirus-1 or -4.
Journal of interferon research    August 1, 1989   Volume 9, Issue 4 389-392 doi: 10.1089/jir.1989.9.389
Edington N, Bridges CG, Griffiths L.When 23 ponies were infected with equid herpesvirus-1 or -4 (EHV-1 or EHV-4), nasal shedding of interferon (IFN) correlated closely with the duration of viral excretion. Equine interferon (EqIFN) was detected in the serum only from animals infected with the EHV-1 virus, and here high levels correlated with clinical symptoms of locomotor disorder and indicated a poor prognosis. Low levels of IFN were detected in explanted mononuclear cells from ponies infected with either virus.
Protection against clinical endotoxemia in horses by using plasma containing antibody to an Rc mutant E. coli (J5).
Circulatory shock    July 1, 1989   Volume 28, Issue 3 235-248 
Spier SJ, Lavoie JP, Cullor JS, Smith BP, Snyder JR, Sischo WM.Thirty-two horses with clinicopathologic evidence of endotoxic shock were randomly selected for a double-blind trial of hyperimmune lipopolysaccharide (LPS) core antigen plasma. Horses were suffering from acute toxic enteritis (n = 15), 360 degrees volvulus of the large colon (n = 9), proximal jejunitis/duodenitis (n = 6), or strangulating obstruction of the small intestine (n = 2). Plasma was harvested from suitable equine plasma donors (preimmune plasma) and horses were immunized with a whole-cell bacterin of an Rc mutant E. coli (J5). Plasma was again harvested from these horses when IgG EL...
A retrospective study of 100 pelvic fractures in horses.
Equine veterinary journal    July 1, 1989   Volume 21, Issue 4 256-259 doi: 10.1111/j.2042-3306.1989.tb02162.x
Rutkowski JA, Richardson DW.The records of 100 horses with clinical or radiographic diagnosis of a pelvic fracture were reviewed to determine prognostic indicators associated with clinical signs or radiographic fracture characteristics. Degree of lameness, soft tissue swelling, crepitis, muscle atrophy, skeletal external assymetry and palpable assymetry on rectal examination were evaluated. There was no significant relationship between the aforementioned clinical signs and the long-term cause outcome. Fracture sites or presence of an acetabular fracture were not related to prognosis. The positive outcome of 77 per cent o...
Treatment of a comminuted middle phalangeal fracture in a horse by use of a broad dynamic compression plate.
Journal of the American Veterinary Medical Association    June 15, 1989   Volume 194, Issue 12 1731-1734 
Bukowiecki CF, Bramlage LR.Comminuted middle phalangeal fractures, extending into the proximal and distal portions of the interphalangeal joint, are associated with a poor prognosis for return to athletic performance. An 11-year-old horse with this type of fracture was treated successfully by use of a broad dynamic compression plate.
Field trial evaluation of detomidine as a sedative and analgesic in horses with colic.
Equine veterinary journal. Supplement    June 1, 1989   Issue 7 117-120 doi: 10.1111/j.2042-3306.1989.tb05669.x
Jöchle W.In this uncontrolled clinical study 12 investigators cooperated to evaluate the analgesic and sedative effect of detomidine (DORMOSEDAN; Farmos Group Ltd; Finland) in 234 horses with abdominal pain caused by colic. The study was designed to use each animal as its own control and to evaluate its response to the drug over a 60 min period. Detomidine was given intravenously (i.v.) once in 169 cases (167 horses, 1 mule, 1 donkey) at a dose of 20 micrograms/kg bodyweight (bwt), and to 65 horses at 40 micrograms/kg bwt. The higher dose was used predominantly in horses with severe pain which were mor...
The effect of low dose heparin therapy on complication and survival rates in horses following exploratory celiotomy.
Equine veterinary journal. Supplement    June 1, 1989   Issue 7 91-93 doi: 10.1111/j.2042-3306.1989.tb05664.x
Young DR, Richardson DW, Markel MD.A randomised, blind prospective study was performed to evaluate effects of low dose heparin therapy on complication and survival rates in 33 horses following exploratory celiotomy. Four horses had non-strangulating lesions and seven had strangulating lesions of the small intestine, 19 had non-strangulating lesions of the large intestine, and three had duodenitis-proximal jejunitis. Eighteen required an enterotomy or intestinal resection and anastomosis. Sixteen received heparin subcutaneously (66 iu/kg every 12 h) post operatively and 17 received a saline placebo for a mean of 3.7 days. There ...
Rectal tears in the horse: an analysis of 35 cases.
Equine veterinary journal    May 1, 1989   Volume 21, Issue 3 186-188 doi: 10.1111/j.2042-3306.1989.tb02138.x
Watkins JP, Taylor TS, Schumacher J, Taylor JR, Gillis JP.The records of 35 horses with Grade 3 or 4 rectal tears, presented to the Veterinary Medical Center at Texas A & M University over a five year period, were reviewed. Grade 3 tears were sub-classified according to whether the remaining tissue was serosa (Grade 3a) or mesorectum (Grade 3b). Five horses were destroyed on presentation and 30 were treated by primary suture closure (8 horses), faecal diversion alone (9 horses) or in combination with suture closure (11 horses) and packing of the tear with medicated gauze sponges (two horses). Faecal diversion was achieved with a temporary indwell...
Fractures of the distal phalanx in the horse.
The Veterinary clinics of North America. Equine practice    April 1, 1989   Volume 5, Issue 1 145-160 doi: 10.1016/s0749-0739(17)30608-9
Yovich JV.Fractures of the distal phalanx are an important cause of lameness referrable to the foot. Depending on the fracture configuration and articular involvement, conservative or surgical treatment may be required. Fractures of the distal phalanx have been divided into six categories based on fracture configuration. Discussion of clinical features, management, and prognosis for horses with distal phalangeal fractures is presented for each fracture type.
Management of lacerations and avulsion injuries of the foot and pastern region and hoof wall cracks.
The Veterinary clinics of North America. Equine practice    April 1, 1989   Volume 5, Issue 1 195-220 doi: 10.1016/s0749-0739(17)30611-9
Stashak TS.The causes, clinical signs and various approaches to treatment of injuries involving the foot and pastern regions are reviewed, and the prognosis for each type of injury is discussed.
Diagnosis and treatment of the navicular syndrome in horses.
The Veterinary clinics of North America. Equine practice    April 1, 1989   Volume 5, Issue 1 131-144 doi: 10.1016/s0749-0739(17)30607-7
Turner TA.Navicular syndrome can be treated in a variety of ways. This is related to the fact that it has a variety of causes. Prognostically, most horses will improve with treatment. One can expect about 50 per cent of the horses to become useably sound for 1 year, no matter what treatment is used. The disease is progressive, and affected horses eventually will need to be retired because of lameness. The author's therapeutic approach is to utilize shoeing as the primary therapy. Shoeing is performed to correct structural problems and to ensure that shoeing is physiologically sound. Nonsteroidal anti-in...
Miscellaneous conditions of the equine foot.
The Veterinary clinics of North America. Equine practice    April 1, 1989   Volume 5, Issue 1 221-242 doi: 10.1016/s0749-0739(17)30612-0
Reeves MJ, Yovich JV, Turner AS.The etiology, clinical presentation, radiographic findings, diagnostic criteria, differential diagnoses, treatment, and prognosis are reviewed for several clinically important conditions of the equine foot. These include pedal osteitis, sheared heels, distal sesamoid bone (navicular) fractures, subchondral bone cyst of the distal phalanx, distal interphalangeal joint subluxation, congenital phalangeal hypoplasia, bipartite and tripartite distal sesamoid bones, keratoma, ossification of the cartilages of the distal phalanx (sidebones), necrosis of the cartilages of the distal phalanx (quittor),...
Open joint injuries in horses: 58 cases (1980-1986).
Journal of the American Veterinary Medical Association    February 1, 1989   Volume 194, Issue 3 398-404 
Gibson KT, McIlwraith CW, Turner AS, Stashak TS, Aanes WA, Trotter GW.A retrospective study was made of 58 horses with open joint injuries admitted to the veterinary teaching hospital. Twenty-five (43%) were admitted within 24 hours of injury, 15 (26%) were examined 2 to 7 days after injury, and 18 (31%) were evaluated a week or more after the initial injury. The joints of the lower portions of the limbs most commonly were affected, with injuries that varied from puncture wounds to severe lacerations with soft tissue deficits. Diagnosis was made on the basis of clinical signs and results of synovial fluid analysis and radiography. Radiography was found to be an ...
Prognosis in equine colic patients using multivariable analysis. Reeves MJ, Curtis CR, Salman MD, Hilbert BJ.Multiple logistic regression was used to investigate prognosis in 308 horses referred to the University of Minnesota veterinary teaching hospital with colic. Bivariate results identified the following significant individual parameters: absent or hypomotile abdominal sounds, medical or surgical classification, peritoneal fluid total protein, anion gap, serum glucose, capillary refill time, blood pH, heart rate, packed cell volume, base excess, serum chloride, plasma bicarbonate, serum urinary nitrogen and age. Two multivariable prognostic models were developed using logistic regression. Model I...
[Diagnostic sonography of the limb of the horse].
Tierarztliche Praxis. Supplement    January 1, 1989   Volume 4 47-55 
van Schie HT.The ultrasonic examination of tendons and ligaments of the distal limb of the horse improves the diagnostic possibilities of these frequently injured structures. The successful application is based upon a reliable knowledge of the normal sonographic anatomy and upon a standardized, flawless technic of the examination. Practice and experience allow the recognition of minor alterations which enables a more precise diagnosis, a more reliable prognosis, and in follow-up examinations also more specific information about the further use of the horse.
Diagnosis and treatment of vesicovaginal reflux in the mare.
The Veterinary clinics of North America. Equine practice    December 1, 1988   Volume 4, Issue 3 407-416 doi: 10.1016/s0749-0739(17)30619-3
Easley KJ.Infertility in the mare associated with VVR must be managed as a complex problem. A complete reproductive evaluation of the mare is required to establish the cause of VVR in order for proper therapy to be recommended. Establishing a prognosis for the mare's future breeding soundness is important to the horse owner and breeding manager. VVR is almost always associated with other reproductive problems and must be dealt with in view of this.
Necrosis of the collateral cartilage of the distal phalanx in horses: 16 cases (1970-1985).
Journal of the American Veterinary Medical Association    November 15, 1988   Volume 193, Issue 10 1303-1307 
Honnas CM, Ragle CA, Meagher DM.The medical records of 16 horses with necrosis of the collateral cartilage of the distal phalanx were reviewed. Typical history included a laceration or puncture wound over the affected cartilage, resulting in persistent drainage proximal to the coronary band. All horses had signs of lameness. The duration of drainage prior to admission to the hospital ranged from 5 days to 5 months. The involved cartilages were left front lateral (n = 4), right front lateral (n = 5), left rear lateral (n = 1), right rear lateral (n = 4), left front medial (n = 1), and left rear medial (n = 1). The affected ca...
Prognostic index for acute abdominal crisis (colic) in horses.
American journal of veterinary research    November 1, 1988   Volume 49, Issue 11 1969-1971 
Orsini JA, Elser AH, Galligan DT, Donawick WJ, Kronfeld DS.Selected physical and laboratory findings in 29 horses with acute abdominal crisis were evaluated retrospectively with a logistic regression equation to predict survival or death. Of 17 variables examined, 2 were found to have good predictive correlation. Serum lactate and packed cell volume had a combined predictive value of 94%. Packed cell volume mean values of 43 and 50%, respectively, differentiated survival from death. Serum lactate values of 28.18 mg/dl and 51.28 mg/dl differentiated survival and death. Analysis of data from a previous study of 36 horses with the logistic regression equ...
Detection of endotoxin in cases of equine colic.
The Veterinary record    September 3, 1988   Volume 123, Issue 10 269-271 doi: 10.1136/vr.123.10.269
King JN, Gerring EL.The Limulus amoebocyte lysate assay was used to test for the presence of endotoxin in 37 clinical cases of equine colic. Positive plasma titres were detected in 10 cases and the presence of endotoxin was significantly correlated with a high heart rate, a high packed cell volume and a poor prognosis. High levels of endotoxin were detected in gut contents taken from several sites in the gastrointestinal tract of normal horses.
Treatment of bacterial endocarditis in a horse.
Journal of the American Veterinary Medical Association    August 1, 1988   Volume 193, Issue 3 339-342 
Dedrick P, Reef VB, Sweeney RW, Morris DD.Using echocardiography, mitral valve bacterial endocarditis was diagnosed in a yearling Thoroughbred filly with a history of periodic fever and intermittent hind limb lameness. Streptococcus sp were isolated from blood, and the filly was treated with penicillin, resulting in a bacteriologic cure. Severe mitral regurgitation developed secondary to scarring of the valve, which resulted in the filly's death. A poor prognosis usually is indicated in horses with bacterial endocarditis, as bacteriologic cures are infrequent and severe valvular insufficiency often develops.
Endometrial biopsy of the mare. A review and update.
The Veterinary clinics of North America. Equine practice    August 1, 1988   Volume 4, Issue 2 229-245 doi: 10.1016/s0749-0739(17)30639-9
Van Camp SD.The endometrial biopsy is a safe and effective means of predicting a mare's prognosis for foaling. A thorough understanding of the normal cyclic and seasonal pattern displayed by the normal endometrium is necessary before interpreting pathologic changes. Several systems for prognostic classification have been proposed, including a recent one that combines many of the criteria used in the other systems.
Effect of equine ehrlichial colitis on the hemostatic system in ponies.
American journal of veterinary research    July 1, 1988   Volume 49, Issue 7 1030-1036 
Morris DD, Messick J, Whitlock RH, Palmer J, Ward MV, Feldman BF.Hemostatic function was determined in 10 ponies at various times after inoculation with Ehrlichia risticii to determine whether equine ehrlichial colitis (EEC) caused changes in the hemostatic system and to determine the prognostic value of hemostatic function tests during EEC. Mean platelet count; plasma fibrinogen, fibronectin, factor VIII: coagulant, alpha 2-antiplasmin, and plasminogen values; and serum concentrations of fibrin/fibrinogen degradation products changed significantly (P less than 0.05) from base line (day 0, before inoculation) during 18 days after inoculation with E risticii...
Decision for surgery.
The Veterinary clinics of North America. Equine practice    April 1, 1988   Volume 4, Issue 1 51-61 doi: 10.1016/s0749-0739(17)30649-1
Ducharme NG, Lowe JE.Based on the clinical impression and the current knowledge of the clinical variables (rectal examination, abdominal distention, abdominal fluid, intractable pain) most likely to differentiate between medical and surgical cases, three decision trees are provided as a guide to making the management decision in a horse with abdominal pain. Prior elimination of horses with limited life expectancy because of age or function or where financial constraints are present is understood. It must be emphasized that most of the information presently available originates from referral centers where the preva...
Development and validation of multivariable models to predict the need for surgery and prognosis in equine colic patients.
Acta veterinaria Scandinavica. Supplementum    January 1, 1988   Volume 84 329-332 
Reeves MJ, Curtis CR, Salman MD, Stashak TS, Reif JS.No abstract available
Development of a scoring system for the early diagnosis of equine neonatal sepsis.
Equine veterinary journal    January 1, 1988   Volume 20, Issue 1 18-22 doi: 10.1111/j.2042-3306.1988.tb01445.x
Brewer BD, Koterba AM.A sepsis scoring system was developed and tested prospectively in a blind study of 190 neonatal foals admitted to the University of Florida Veterinary Medical Teaching Hospital's neonatal intensive care unit. The system used 14 readily available historical, clinical or laboratory variables and weighted each item to arrive at a sepsis score. The score was found to have a sensitivity of 93 per cent, a specificity of 86 per cent, positive accuracy rate of 89 per cent and negative accuracy rate of 92 per cent. The sepsis score was far more sensitive and specific for infection, even in very early c...
Results of operative treatment of equine colic with special reference to surgery of the ileum.
The veterinary quarterly    January 1, 1988   Volume 10, Issue 1 17-25 doi: 10.1080/01652176.1988.9694141
Kersjes AW, Bras GE, Németh F, van der Velden MA, Firth EC.This retrospective study presents the results of surgical treatment of obstructive colic in horses operated in the last decade (1976-1985). The overall short-term recovery rate (i.e. discharged from hospital) was 51% of cases presented for surgery, and 68% of cases which were considered to be amenable to surgical therapy. For long-term results (6 months-8 years follow up) these percentages must be reduced by about 15% due to mortality after discharge. Special attention has been given to surgery of the ileum, which is often involved in strangulation or obturation, and accounts for about 26% of ...
Factors affecting prognosis and conversion in equine atrial fibrillation.
Journal of veterinary internal medicine    January 1, 1988   Volume 2, Issue 1 1-6 doi: 10.1111/j.1939-1676.1988.tb01970.x
Reef VB, Levitan CW, Spencer PA.Sixty-seven horses presented with atrial fibrillation (AF) from January 1, 1980 to August 1, 1986. All horses were evaluated for the type and severity of the underlying cardiac disease and the probable duration of the arrhythmia. Fifty-two (78%) of the horses were treated with quinidine sulfate and/or digoxin. The response to treatment was assessed in each horse. Horses were followed for periods extending from 8 months to 7 years. Standardbreds, young horses, and males predominated in the study group. There were more male horses (stallions and geldings) than mares. Most horses with AF had no e...
Laboratory diagnosis and characterization of renal disease in horses.
The Veterinary clinics of North America. Equine practice    December 1, 1987   Volume 3, Issue 3 585-615 doi: 10.1016/s0749-0739(17)30666-1
Kohn CW, Chew DJ.Laboratory evaluation of renal function in horses has advanced dramatically in the last 10 years largely as a result of the interest generated by the creative approach to diagnostic indices taken by Brobst, Traver, Coffman, and others. Some methods of assessing renal function discussed here are clearly outside the scope of a practice environment but are available in referral hospitals for use in difficult or unusual cases. Other methods described, such as calculation of fractional excretions and urine to serum creatinine ratios, are accessible and readily interpreted by the veterinary practiti...
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