Topic:Promazine
Promazine is a phenothiazine derivative used in equine medicine primarily as a sedative and tranquilizer. It acts on the central nervous system to produce calming effects, which can be beneficial in managing anxiety or stress in horses during veterinary procedures or transportation. Promazine is administered either orally or via injection, and its dosage and effects can vary depending on the individual horse and the intended use. Its mechanism involves blocking dopamine receptors, which contributes to its sedative properties. This page compiles peer-reviewed research studies and scholarly articles that explore the pharmacokinetics, efficacy, and safety of promazine in horses, as well as its applications in equine veterinary practice.
Stimulation of food intake in horses by diazepam and promazine. In two adult horses doses of 0.02-0.03 mg/kg diazepam, intravenously, increased 1 hr intake 54-75% above control levels. Intake was stimulated when the diet was a high grain, calorically dense one and also when the diet was a high fiber, calorically dilute one. Two young rapidly growing weanling horses showed an even more pronounced stimulation of intake. Following diazepam 1 hr intake was increased 105-240% above control lelvels. Promazine at a dose of 0.5 mg/kg also stimulated intake in adult horses, but not as markedly as did diazepam. A transquilizer and a neuroleptic appear to have a stim...
Evaluation of xylazine as a sedative and preanesthetic agent in horses. Xylazine administered intramuscularly (IM) to horses at the dose level of 2 mg/kg was an effective sedative and preanesthetic for thiamylal sodium narcosis or thiamylal sodium and halothane anesthesia. Evaluation of response of cardiovascular, respiratory, and hepatic function did not indicate serious untoward effects, although cardiac and respiratory rate decreased, calculated vigor of left ventricular contraction decreased, calculated peripheral vascular resistance increased, and transient innocuous cardiac arrhythmias occurred. Effects of the anesthetics used on respiratory function (blood ...