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Topic:Veterinary Research

Veterinary research in horses encompasses the study of diseases, health management, and medical treatments specific to equine species. This field investigates various aspects of horse health, including infectious diseases, metabolic disorders, and musculoskeletal conditions. Researchers focus on understanding the pathophysiology of equine ailments, developing diagnostic tools, and evaluating therapeutic interventions. The study of horse health also involves examining preventive measures such as vaccination protocols and nutritional management to promote overall well-being. This page collects peer-reviewed research studies and scholarly articles that explore the diverse areas of veterinary science related to horses, providing insights into disease mechanisms, treatment strategies, and advancements in equine healthcare.
Identification and characterisation of beta-adrenoceptors on intact equine peripheral blood lymphocytes with the radioligand (-)-[125I]-iodocyanopindolol.
Equine veterinary journal    September 18, 2001   Volume 33, Issue 5 487-493 doi: 10.2746/042516401776254862
Abraham G, Broddet OE, Ungemach FR.In this study, beta-adrenoceptors of intact equine lymphocytes were identified and subclassified by (-)-[125I]-iodocyanopindolol (ICYP) binding. ICYP binding to intact equine lymphocytes was rapid, saturable (maximal number of binding sites 320 +/- 20 ICYP binding sites/cell, n = 12) and of high affinity (KD value for ICYP 14.4 +/- 1.7 pmol/l, n = 12). Binding was stereospecific as shown by the 10 times greater potency of (-)-propranolol to inhibit binding than its (+)-isomer. Beta-adrenoceptor agonists inhibited ICYP binding with an order of potency: (-)-isoprenaline >(-)-adrenaline >(-...
Organogenesis of lung and kidney in Thoroughbreds and ponies.
Equine veterinary journal    September 18, 2001   Volume 33, Issue 5 438-445 doi: 10.2746/042516401776254907
Beech DJ, Sibbons PD, Rossdale PD, Ousey JC, Holdstock NB, Chavatte P, Ansari T.Equine lung and kidney organogenesis has not previously been examined with the use of unbiased stereological techniques. The present study examined healthy (control) pony and Thoroughbred lungs and kidneys to establish baseline data of organ development from before birth until maturity at age 3-18 years. Whole left lungs and kidneys were collected from 45 equine postmortem examinations (34 Thoroughbred, 11 pony). Stereological techniques were used to estimate whole kidney, cortex and medulla volume, total glomerular number and volume-weighted mean glomerular volume, lung volume, total terminal...
X chromosome detection in an XO mare using a human X paint probe, and PCR detection of SRY and amelogenin genes in 3 XY mares.
Equine veterinary journal    September 18, 2001   Volume 33, Issue 5 527-530 doi: 10.2746/042516401776254844
Mäkinen A, Suojala L, Niini T, Katila T, Tozaki T, Miyake Y, Hasegawa T.No abstract available
Genetic diversity in Spanish donkey breeds using microsatellite DNA markers.
Genetics, selection, evolution : GSE    September 18, 2001   Volume 33, Issue 4 433-442 doi: 10.1186/1297-9686-33-4-433
Aranguren-Méndez J, Jordana J, Gomez M.Genetic diversity at 13 equine microsatellite loci was compared in five endangered Spanish donkey breeds: Andaluza, Catalana, Mallorquina, Encartaciones and Zamorano-Leonesa. All of the equine microsatellites used in this study were amplified and were polymorphic in the domestic donkey breeds with the exception of HMS1, which was monomorphic, and ASB2, which failed to amplify. Allele number, frequency distributions and mean heterozygosities were very similar among the Spanish donkey breeds. The unbiased expected heterozygosity (H(E)) over all the populations varied between 0.637 and 0.684 in t...
Signal decomposition method of evaluating head movement to measure induced forelimb lameness in horses trotting on a treadmill.
Equine veterinary journal    September 18, 2001   Volume 33, Issue 5 446-451 doi: 10.2746/042516401776254781
Keegan KG, Pai PF, Wilson DA, Smith BK.In horses at a trot, the head moves up and down twice in one stride. In horses with unilateral forelimb lameness this movement is asymmetric. Computer-assisted kinematic analysis of vertical head movement can be used to quantify objectively lameness in horses in clinical trials. However, in mild lameness, absolute measurements of vertical head height may not be sensitive enough to detect small differences in lameness, and extraneous head movement by the horse due to curiosity, excitement or nervousness interferes with the accurate measurement of vertical head movement asymmetry. We describe a ...
Random positions and directions is best: lessons from tissue sampling practices of the stereologist.
Equine veterinary journal    September 18, 2001   Volume 33, Issue 5 426-427 doi: 10.2746/042516401776254853
Mayhew TM.No abstract available
Plasma pharmacokinetics and faecal excretion of ivermectin, doramectin and moxidectin following oral administration in horses.
Equine veterinary journal    September 18, 2001   Volume 33, Issue 5 494-498 doi: 10.2746/042516401776254835
Gokbulut C, Nolan AM, McKellar QA.The present study was carried out to investigate whether the pharmacokinetics of avermectins or a milbemycin could explain their known or predicted efficacy in the horse. The avermectins, ivermectin (IVM) and doramectin (DRM), and the milbemycin, moxidectin (MXD), were each administered orally to horses at 200 microg/kg bwt. Blood and faecal samples were collected at predetermined times over 80 days (197 days for MXD) and 30 days, respectively, and plasma pharmacokinetics and faecal excretion determined. Maximum plasma concentrations (Cmax) (IVM: 21.4 ng/ml; DRM: 21.3 ng/ml; MXD: 30.1 ng/ml) w...
The advance of clinical biomechanics.
Equine veterinary journal    September 18, 2001   Volume 33, Issue 5 430-432 doi: 10.2746/042516401776254754
Buchner HH.No abstract available
A study of an electrodiagnostic technique for the evaluation of equine recurrent laryngeal neuropathy.
Equine veterinary journal    September 18, 2001   Volume 33, Issue 5 459-465 doi: 10.2746/042516401776254826
Hawe C, Dixon PM, Mayhew IG.The electrodiagnostic measurement of the thoracolaryngeal reflex (TLR) ('slap test') latency was compared to 5 other diagnostic techniques used for evaluation of laryngeal function, namely laryngeal muscle palpation, resting and immediately postexercise endoscopic examinations, and palpable and endoscopic responses to the TLR. Compared to resting endoscopy, the electrodiagnostic measurement of TLR latency was not found to be an accurate test for the evaluation of recurrent laryngeal neuropathy (RLN), nor was laryngeal muscle palpation or the endoscopic response to the TLR. Twenty-five (71%) of...
Laryngeal paralysis: a study of 375 cases in a mixed-breed population of horses.
Equine veterinary journal    September 18, 2001   Volume 33, Issue 5 452-458 doi: 10.2746/042516401776254790
Dixon PM, McGorum BC, Railton DI, Hawe C, Tremaine WH, Pickles K, McCann J.Referred cases (n = 375) of laryngeal paralysis (1985-1998) from a mixed-breed equine population included 351 (94%) cases of recurrent laryngeal neuropathy (RLN) (idiopathic laryngeal hemiplegia) and 24 cases (6%) of laryngeal paralysis from causes other than RLN. Laryngeal movements were classified endoscopically into one of 6 grades, in contrast to the usual 4 grades. The RLN cases had a median grade 4 laryngeal paralysis, of which 96% were left-sided, 2% right-sided and 2% bilaterally affected. RLN cases included 204 (58%) Thoroughbred, 96 (27%) Thoroughbred-cross, 23 (7%) draught, 16 (5%) ...
The effects of treadmill inclination and speed on the activity of three trunk muscles in the trotting horse.
Equine veterinary journal    September 18, 2001   Volume 33, Issue 5 466-472 doi: 10.2746/042516401776254745
Robert C, Valette JP, Denoix JM.The purpose of this study was to evaluate the effects of speed and slope on the activity of trunk muscles. The electromyographic (EMG) activity of the splenius (Sp), longissimus dorsi (LD) and rectus abdominis (RA) muscles was recorded with surface electrodes during treadmill locomotion at trot for different combinations of speed (3.5 to 6 m/s) and slope (0 to 6%). Raw EMG signals were processed to determine activity duration, onset and end and integrated EMG (IEMG). For the 3 muscles investigated, onset and end of activity were obtained earlier in the stride cycle when speed increased. A long...
Suspected septic physitis of the proximal humerus in two cases of Thoroughbred horses age two years.
Equine veterinary journal    September 18, 2001   Volume 33, Issue 5 514-518 doi: 10.2746/042516401776254880
Ramzan PH, Pilsworth RC.No abstract available
Differences in wound contraction between horses and ponies: the in vitro contraction capacity of fibroblasts.
Equine veterinary journal    September 18, 2001   Volume 33, Issue 5 499-505 doi: 10.2746/042516401776254817
Wilmink JM, Nederbragt H, van Weeren PR, Stolk PW, Barneveld A.The contribution of wound contraction to wound closure determines the speed of second intention wound healing and it has been shown that significant differences exist with regard to both contraction and inflammatory response between horses and ponies and between various areas of the body. In this study, the contraction capacity of fibroblasts from limbs and buttocks of 4 Dutch Warmblood horses and 4 Shetland ponies was studied in vitro, in order to determine whether differences in wound contraction are due to differences in the inherent contraction capacity of the fibroblasts or to differences...
Differential inhibition of equine neutrophil function by phosphodiesterase inhibitors.
Journal of veterinary pharmacology and therapeutics    September 14, 2001   Volume 24, Issue 4 275-281 doi: 10.1046/j.1365-2885.2001.00344.x
Rickards KJ, Page CP, Lees P, Cunningham FM.Neutrophils are recruited to the lungs of horses with chronic obstructive pulmonary disease (COPD) and exhibit increased activity after antigen challenge, which may contribute to inflammation and lung damage. Inhibition of phosphodiesterase isoenzymes (PDEs) has been shown to attenuate human neutrophil functions including superoxide production, leukotriene (LT)B4 biosynthesis, enzyme and chemokine release. As equine neutrophils contain predominantly the isoenzyme, PDE4, the present study was undertaken to investigate the effects of rolipram, a PDE4 inhibitor, on equine neutrophil function. For...
The effect of recurrent laryngeal neurectomy in conjunction with laryngoplasty and unilateral ventriculocordectomy in thoroughbred racehorses.
Veterinary surgery : VS    September 14, 2001   Volume 30, Issue 5 417-421 doi: 10.1053/jvet.2001.25865
Davenport CL, Tulleners EP, Parente EJ.To investigate the effects of recurrent laryngeal neurectomy (RLN) in combination with laryngoplasty and ventriculocordectomy on the postoperative performance of Thoroughbred racehorses treated for grade III left laryngeal hemiparesis (LLH). Methods: Retrospective study. Methods: Fifty-five Thoroughbred racehorses. Methods: Medical records for Thoroughbred racehorses treated surgically by laryngoplasty and laser ventriculocordectomy with or without RLN between June 1993 and December 1996 were reviewed. Outcome was evaluated subjectively by assessment of performance obtained from telephone inte...
Polymerase chain reaction analysis of the surgical margins of equine sarcoids for bovine papilloma virus DNA.
Veterinary surgery : VS    September 14, 2001   Volume 30, Issue 5 460-467 doi: 10.1053/jvet.2001.25874
Martens A, De Moor A, Demeulemeester J, Peelman L.To examine apparently normal skin around equine sarcoids for evidence of bovine papilloma virus (BPV) DNA, and to relate this finding to the observed recurrence after surgery. Methods: Prospective study. Methods: Forty-one equine sarcoids from 19 horses. Methods: The tumors were surgically excised at a measured distance of 8, 12, or 16 mm. Samples from the tumor and of the entire surrounding skin were taken at 4, 8, 12, and 16 mm from the tumor border and analyzed for the presence of BPV DNA using polymerase chain reaction (PCR) amplification. The samples were grouped per examined sarcoid, and...
Laparoscopic surgical technique for repair of rectal and colonic tears in horses: an experimental study.
Veterinary surgery : VS    September 14, 2001   Volume 30, Issue 5 409-416 doi: 10.1053/jvet.2001.25864
Brugmans F, Deegen E.To determine the efficacy of laparoscopic surgical techniques for repair of rectal lacerations in horses. Methods: Experimental study. Methods: Thirty-two segments of equine bowel placed in an equine pelvitrainer, 8 equine cadavers, and 3 normal horses. Methods: In experiment 1, 3 laparoscopic intestinal-repair techniques were evaluated in an equine pelvitrainer: suturing with needle holders, with an automatic suture device, and stapling with a hernia stapler. In experiment 2, descending colon lacerations were sutured laparoscopically using needle holders in a pelvitrainer and in equine cadave...
Analgesic effect of butorphanol and levomethadone in detomidine sedated horses.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine    September 14, 2001   Volume 48, Issue 6 337-342 doi: 10.1046/j.1439-0442.2001.00366.x
Schatzman U, Armbruster S, Stucki F, Busato A, Kohler I.The analgesic potency of butorphanol 25 microg/kg bodyweight (BW) and levomethadone 100 microg/kg BW, administered together with detomidine 10 microg/kg BW, was measured in twelve Warmblood horses in a randomized, blinded cross-over study. Detomidine with saline 10 ml 0.9% was used as placebo. The nociceptive threshold was determined using a constant current and a pneumatic pressure model for somatic pair Detomidine alone and in combination with butorphanol or levomethadone caused a significant temporary increase (P < 0.05) of the nociceptive threshold with a maximum effect within 15 min and a...
An in vitro biomechanical investigation of an intramedullary nailing technique for repair of third metacarpal and metatarsal fractures in neonates and foals.
Veterinary surgery : VS    September 14, 2001   Volume 30, Issue 5 422-431 doi: 10.1053/jvet.2001.25866
Fitch GL, Galuppo LD, Stover SM, Willits NH.To evaluate a dorsoproximal extra-articular approach for insertion of 8.25-mm, solid-titanium, intramedullary (IM) interlocking nails into ostectomized foal third metacarpal (MC3) and third metatarsal (MT3) bones; to compare the monotonic mechanical properties of IM nail constructs with paired intact bones; and to determine the effects of age, body weight, fore- or hindlimb, and left or right limb on the mechanical testing variables. Methods: Twenty bone pairs (10 MC3, 10 MT3) collected from 10 foals of various weights and ages. Methods: One bone from each pair was randomly selected to be oste...
Interaction of cimetidine with equine hemoglobin.
Journal of veterinary pharmacology and therapeutics    September 14, 2001   Volume 24, Issue 4 299-302 doi: 10.1046/j.1365-2885.2001.00350.x
Hunter RP, Short CR, Dees AA.No abstract available
Organisation of the cytoskeleton during in vitro maturation of horse oocytes.
Molecular reproduction and development    September 13, 2001   Volume 60, Issue 2 260-269 doi: 10.1002/mrd.1086
Tremoleda JL, Schoevers EJ, Stout TA, Colenbrander B, Bevers MM.Meiotic maturation of mammalian oocytes is a complex process during which microfilaments and microtubules provide the framework for chromosomal reorganisation and cell division. The aim of this study was to use fluorescence and confocal laser scanning microscopy to examine changes in the distribution of these important cytoskeletal elements and their relationship to chromatin configuration during the maturation of horse oocytes in vitro. Oocytes were cultured in M199 supplemented with pFSH and eLH and, at 0, 12, 24, and 36 hr after the onset of culture, they were fixed for immunocytochemistry ...
DEFRA’s proposals on equine dentistry.
The Veterinary record    September 11, 2001   Volume 149, Issue 7 219 
Barbour-Hill E.No abstract available
Influence of oocyte collection technique on initial chromatin configuration, meiotic competence, and male pronucleus formation after intracytoplasmic sperm injection (ICSI) of equine oocytes.
Molecular reproduction and development    September 11, 2001   Volume 60, Issue 1 79-88 doi: 10.1002/mrd.1064
Dell'Aquila ME, Masterson M, Maritato F, Hinrichs K.There is a great variability in the success of horse oocyte maturation and fertilization among laboratories. This study was conducted to determine if the meiotic and developmental competence of horse oocytes could be dependent on the method of oocyte collection, i.e., aspiration of follicular fluid with a vacuum apparatus, or opening follicles and scraping the granulosa layer. Horse oocytes were recovered from abattoir ovaries by aspiration or scraping and classified as having compact (Cp), expanded (Ex), or partial (P) cumuli. In Experiment 1 (Part A in May and Part B in October), oocytes wer...
Renal hypoplasia and dysplasia in an American miniature foal.
The Veterinary record    September 11, 2001   Volume 149, Issue 7 199-203 doi: 10.1136/vr.149.7.199
Gull T, Schmitz DG, Bahr A, Read WK, Walker M.Diagnostic imaging, including computed tomography, of a two-month-old foal with renal failure indicated that its right kidney was probably absent and that its left kidney was abnormal in shape. The foal was stabilised and released, but three days later its clinical signs recurred. Postmortem examination revealed renal hypoplasia and dysplasia, the first reported case of this condition in an American miniature horse.
Traceability of Equidae: a population in motion.
Revue scientifique et technique (International Office of Epizootics)    September 11, 2001   Volume 20, Issue 2 500-509 doi: 10.20506/rst.20.2.1292
Sluyter FJ.The accelerated speed of animal transport and the existence of complex and intricate movement systems have created an equine population in motion. This ease in the international movement of horses has an impact on the risk of introduction or spread of disease, specifically in relation to competition horses. Facilitating trade in Equidae, whilst simultaneously safeguarding the health status of the receiving country is a major challenge. To date, the international regulatory bodies are prepared to consider movement of registered horses as a relatively 'low risk' occurrence and thereby apply the ...
Serological diagnosis of equine influenza using the hemagglutinin protein produced in a baculovirus expression system.
Journal of virological methods    September 7, 2001   Volume 98, Issue 1 1-8 doi: 10.1016/s0166-0934(01)00332-9
Sugiura T, Sugita S, Imagawa H, Kanaya T, Ishiyama S, Saeki N, Uchiyama A, Tanigawa M, Kuwano A.The hemagglutinin (HA) protein of an equine influenza strain, A/equine/La Plata/1/93 (LP/93), was produced using a baculovirus expression system. Silkworm larvae inoculated with recombinant baculovirus expressed high quantities of the HA protein which was then purified to greater than 95% purity by fetuin-affinity chromatography. Purified HA protein was used subsequently in an ELISA for detection of antibodies in horse sera. Two hundred serum samples from vaccinated racehorses were reacted on ELISA plates coated with 40.0 ng/ml of purified HA protein. Subsequent optical density (OD) levels rev...
High density lipoprotein cholesteryl ester metabolism in the pony, an animal species without plasma cholesteryl ester transfer protein activity: transfer of high density lipoprotein cholesteryl esters to lower density lipoproteins and the effect of the amount of fat in the diet.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology    September 7, 2001   Volume 130, Issue 2 145-154 doi: 10.1016/s1096-4959(01)00416-x
Geelen SN, Lemmens AG, Terpstra AH, Wensing T, Beynen AC.The metabolism of high density lipoprotein cholesteryl esters (HDL CE) was studied in the pony, an animal species without plasma cholesteryl ester transfer protein (CETP) activity. Studies were done in ponies fed a low- (1.5% fat, w/w) and a high-fat diet (11.5%, w/w fat). The ponies fed the high-fat diet had higher plasma HDL CE concentrations (1.08+/-0.15 vs. 0.84+/-0.11 mmol/l, mean+/-S.D., n=6, P<0.01) and plasma lipoprotein lipase (LPL) activities (14.3+/-4.0 vs. 5.7+/-3.4 micromol free fatty acids (FFA)/ml per h, P<0.05) than those on the low-fat diet. Plasma triacylglycerol (TAG) ...
[The phylogenesis of equine teeth].
Anatomia, histologia, embryologia    September 6, 2001   Volume 30, Issue 4 237-248 doi: 10.1046/j.1439-0264.2001.00328.x
Vollmerhaus B, Knospe C, Roos H.Phylogenetic research on the teeth of equidae beginning with dagger Hyracotherium ('Eohippus') will be summarized, subdivided into its components, analysed in a new way and finally interpreted according to several theories of evolution. In this context, specific cells (ameloblasts, odontoblasts, cementoblasts) are discussed and valued according to Preuss (1987) as active carriers of the evolution of teeth.
The influence of lameness on equine stride length consistency.
Veterinary journal (London, England : 1997)    September 5, 2001   Volume 162, Issue 2 153-157 doi: 10.1053/tvjl.2001.0593
Peham C, Licka T, Girtler D, Scheidl M.The aim of this study was to assess the influence of orthopaedic pain on the variation of stride length as a kinematic system-parameter in 21 horses with forelimb lameness. Data were collected while the horses were trotting on a treadmill during a minimum of 12 motion cycles, both before and after intra-articular or perineural anaesthesia. Stride length was assessed for each motion cycle, and the mean and standard deviation were calculated for each condition. Forelimb lameness was documented as percentage of asymmetry of vertical head movement. With significant decrease of forelimb lameness af...
Diagnosis of secondary hyperparathyroidism in a pony using intact parathyroid hormone radioimmunoassay.
The Veterinary record    September 4, 2001   Volume 149, Issue 6 185-187 doi: 10.1136/vr.149.6.185
Benders NA, Junker K, Wensing T, van den Ingh TS, van der Kolk JH.No abstract available