18 F-sodium fluoride positron emission tomography of the equine distal limb: Exploratory study in three horses.
Abstract: Positron emission tomography (PET) is a cross-sectional, functional imaging modality that has recently become available to the horse. The use of 18 F-sodium fluoride (18 F-NaF), a PET bone tracer, has not previously been reported in this species. Objective: To assess the feasibility of 18 F-NaF PET in the equine distal limb and explore possible applications in the horse in comparison with other imaging modalities. Methods: Exploratory descriptive study involving three research horses. Methods: Horses were placed under general anaesthesia prior to intravenous (i.v.) administration of 1.5 MBq/kg of 18 F-NaF. Positron emission tomography imaging of both front feet and fetlocks was performed using a portable scanner. Computed tomography (CT) of the distal limb was performed under a separate anaesthetic episode. Bone scintigraphy and magnetic resonance imaging (MRI) were subsequently performed under standing sedation. Images obtained from PET and other imaging modalities were independently assessed and the results correlated. Results: Positron emission tomography images were obtained without complication. The radiation exposure rate was similar to equine bone scintigraphy. Positron emission tomography detected focal 18 F-NaF uptake in areas where other imaging modalities did not identify any abnormalities. This included sites of ligamentous attachment, subchondral compact bone plate and the flexor cortex of the navicular bone. 18 F-NaF uptake was identified in some, but not all, osseous fragments and areas of osseous formation, suggesting a distinction between active and inactive lesions. Conclusions: A small number of horses were included and histopathology was not available. Conclusions: 18 F-NaF PET imaging of the equine distal limb provides useful additional information when compared with CT, MRI and scintigraphy and has the potential for both research and clinical applications in the horse. The Summary is available in Chinese - see Supporting information.
© 2017 EVJ Ltd.
Publication Date: 2017-08-18 PubMed ID: 28707737DOI: 10.1111/evj.12719Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Clinical Trial
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This study explores the use of positron emission tomography (PET) using F-sodium fluoride (F-NaF) as a bone tracer in horses. Three horses underwent F-NaF PET imaging of the front feet and fetlocks to assess its feasibility and possible applications compared to other imaging methods.
Methodology
The study used an exploratory descriptive approach involving three research horses. Key steps included:
- General anesthesia was administered to the horses prior to the study.
- 1.5 MBq/kg of F-NaF was administered intravenously.
- PET imaging of both front feet and fetlocks was performed using a portable scanner.
- Computed Tomography (CT) of the distal limb was performed under a separate anesthetic episode.
- Bone scintigraphy and Magnetic Resonance Imaging (MRI) were subsequently performed under standing sedation.
Images obtained from PET and other imaging modalities were then independently assessed and the results correlated.
Results
- PET images were successfully obtained without any complications.
- The radiation exposure rate was comparable to that of equine bone scintigraphy.
- PET detected focal F-NaF uptake in areas where other imaging tools did not identify any abnormalities. This included sites of ligamentous attachment, the subchondral compact bone plate, and the flexor cortex of the navicular bone.
- F-NaF uptake was identified in some, but not all, osseous fragments and areas of osseous formation. This suggests the ability to distinguish between active and inactive lesions.
Conclusion
While the study was conducted on a small number of horses, the findings indicated that F-NaF PET imaging provides valuable additional information not captured by CT, MRI, and scintigraphy. The technique shows promise for both research and clinical applications in horses. Further investigation is required due to the small sample size and a lack of histopathological data.
Cite This Article
APA
Spriet M, Espinosa P, Kyme AZ, Phillips KL, Katzman SA, Galuppo LD, Stepanov P, Beylin D.
(2017).
18 F-sodium fluoride positron emission tomography of the equine distal limb: Exploratory study in three horses.
Equine Vet J, 50(1), 125-132.
https://doi.org/10.1111/evj.12719 Publication
Researcher Affiliations
- University of California, Davis, California, USA.
- University of California, Davis, California, USA.
- University of California, Davis, California, USA.
- University of California, Davis, California, USA.
- University of California, Davis, California, USA.
- University of California, Davis, California, USA.
- Brain Biosciences, Inc., Rockville, Maryland, USA.
- Brain Biosciences, Inc., Rockville, Maryland, USA.
MeSH Terms
- Animals
- Female
- Forelimb / diagnostic imaging
- Horses
- Male
- Positron-Emission Tomography / veterinary
- Radiopharmaceuticals / pharmacology
- Sodium Fluoride / pharmacology
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
