Journal of veterinary internal medicine2012; 26(6); 1251-1266; doi: 10.1111/j.1939-1676.2012.00994.x

A comparative review of vitamin E and associated equine disorders.

Abstract: Vitamin E is a primary chain-breaking antioxidant that prevents cyclic propagation of lipid peroxidation. Across species, vitamin E is essential for normal neuromuscular function by acting as a potent antioxidant, as well as by modulating the expression of certain genes, inhibiting platelet aggregation and stabilizing plasma membranes. This review focuses on vitamin E structure, absorption, metabolism, current equine dietary recommendations, the interplay between antioxidants and exercise, a discussion of the necessity of vitamin E supplementation in the horse above the Nutritional Research Council (NRC) 2007 requirements, and a review of equine diseases that are associated with a vitamin E deficiency. Particular emphasis is placed on the proteins involved in vitamin E absorption, transport, and metabolism as potential candidates for vitamin E-associated diseases across species.
Publication Date: 2012-08-27 PubMed ID: 22925200DOI: 10.1111/j.1939-1676.2012.00994.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
  • Journal Article
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is a comparative review of the function of vitamin E and its relation to various disorders in horses, highlighting its crucial role as an antioxidant, influence on gene expression, platelet aggregation inhibition, and plasma membrane stabilization.

Vitamin E Structure, Absorption, and Metabolism

In this study, the researchers provide information about vitamin E’s structure, absorption process, and metabolism. Vitamin E is a primary chain-breaking antioxidant, which indicates its critical role in preventing the cyclic propagation of lipid peroxidation. Lipid peroxidation refers to the oxidative degradation of lipids in the body, a process that can lead to cell damage and various health disorders. Proper understanding of the absorption and metabolism processes of Vitamin E is crucial as these steps influence its functionality within an organism.

Equine Dietary Recommendations

The study also delves into the current recommendations for dietary vitamin E intake for horses. The researchers reference the Nutritional Research Council (NRC) 2007 requirements advising on the amount of vitamin E necessary to maintain a healthy equine system. The nutritional needs of horses largely depict their health and performance, and as vitamin E impacts several vital processes in their bodies, it is paramount that its intake is adequately regulated.

Antioxidants, Exercise, and Vitamin E Supplementation

The relationship between antioxidants, exercise, and the necessity of vitamin E supplementation beyond the recommended NRC 2007 requirements is also discussed. Exercise triggers an increased metabolic rate which can cause oxidative stress in the equine body. Consequently, horses, particularly those in high-performance settings, may require additional vitamin E supplementation to combat this oxidative stress and maintain cellular health.

Vitamin E-Associated Diseases

The focus of the study is on equine diseases associated with a vitamin E deficiency. This emphasis is necessary as understanding the link between such diseases and deficiency could assist in prevention, early detection, and treatment options. Knowing which diseases are likely to occur from a deficiency in vitamin E could motivate better supplementation practices for equine health.

Protein Involvement in Vitamin E Absorption, Transport, and Metabolism

Finally, the study highlights proteins that participate in vitamin E absorption, transport, and metabolism as potential candidates for vitamin E-associated diseases. Understanding the relationships among these proteins, and their individual roles, could guide future research and provide new insights into combatting equine disorders related to vitamin E deficiency.

Cite This Article

APA
Finno CJ, Valberg SJ. (2012). A comparative review of vitamin E and associated equine disorders. J Vet Intern Med, 26(6), 1251-1266. https://doi.org/10.1111/j.1939-1676.2012.00994.x

Publication

ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 26
Issue: 6
Pages: 1251-1266

Researcher Affiliations

Finno, C J
  • Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USA. cjfinno@ucdavis.edu
Valberg, S J

    MeSH Terms

    • Animals
    • Antioxidants / pharmacology
    • Horse Diseases / drug therapy
    • Horse Diseases / prevention & control
    • Horses
    • Vitamin E / pharmacology

    Citations

    This article has been cited 20 times.
    1. Peng S, Magdesian KG, Dowd J, Blea J, Carpenter R, Ho W, Finno CJ. Investigation of high gamma-glutamyltransferase syndrome in California Thoroughbred racehorses.. J Vet Intern Med 2022 Nov;36(6):2203-2212.
      doi: 10.1111/jvim.16582pubmed: 36377652google scholar: lookup
    2. Owen RN, Semanchik PL, Latham CM, Brennan KM, White-Springer SH. Elevated dietary selenium rescues mitochondrial capacity impairment induced by decreased vitamin E intake in young exercising horses.. J Anim Sci 2022 Aug 1;100(8).
      doi: 10.1093/jas/skac172pubmed: 35908793google scholar: lookup
    3. Bedenice D, Johnson AL. Neurologic conditions in the sport horse.. Anim Front 2022 Jun;12(3):37-44.
      doi: 10.1093/af/vfac036pubmed: 35711509google scholar: lookup
    4. Hales EN, Habib H, Favro G, Katzman S, Sakai RR, Marquardt S, Bordbari MH, Ming-Whitfield B, Peterson J, Dahlgren AR, Rivas V, Ramirez CA, Peng S, Donnelly CG, Dizmang BS, Kallenberg A, Grahn R, Miller AD, Woolard K, Moeller B, Puschner B, Finno CJ. Increased u03b1-tocopherol metabolism in horses with equine neuroaxonal dystrophy.. J Vet Intern Med 2021 Sep;35(5):2473-2485.
      doi: 10.1111/jvim.16233pubmed: 34331715google scholar: lookup
    5. Donnelly CG, Burns E, Easton-Jones CA, Katzman S, Stuart R, Cook SE, Finno CJ. Safety and efficacy of subcutaneous alpha-tocopherol in healthy adult horses.. Equine Vet Educ 2021 Apr;33(4):215-219.
      doi: 10.1111/eve.13308pubmed: 34326575google scholar: lookup
    6. Nemec Svete A, Vovk T, Bohar Topolovec M, Kruljc P. Effects of Vitamin E and Coenzyme Q(10) Supplementation on Oxidative Stress Parameters in Untrained Leisure Horses Subjected to Acute Moderate Exercise.. Antioxidants (Basel) 2021 Jun 3;10(6).
      doi: 10.3390/antiox10060908pubmed: 34205129google scholar: lookup
    7. Habib H, Finno CJ, Gennity I, Favro G, Hales E, Puschner B, Moeller BC. Simultaneous quantification of vitamin E and vitamin E metabolites in equine plasma and serum using LC-MS/MS.. J Vet Diagn Invest 2021 May;33(3):506-515.
      doi: 10.1177/10406387211005433pubmed: 33847203google scholar: lookup
    8. Finno CJ. Veterinary Pet Supplements and Nutraceuticals.. Nutr Today 2020 Mar-Apr;55(2):97-101.
      doi: 10.1097/nt.0000000000000399pubmed: 33446942google scholar: lookup
    9. Ranard KM, Kuchan MJ, Erdman JW Jr. Breeder Diet Strategies for Generating Ttpa-Null and Wild-Type Mice with Low Vitamin E Status to Assess Neurological Outcomes.. Curr Dev Nutr 2020 Nov;4(11):nzaa155.
      doi: 10.1093/cdn/nzaa155pubmed: 33173842google scholar: lookup
    10. Cappai MG, Taras A, Cossu I, Cherchi R, Dimauro C, Accioni F, Boatto G, Deroma M, Spanu E, Gatta D, Dall'Aglio C, Pinna W. Effects of Dietary Zn/Se and u03b1-Tocopherol Supplementation on Metabolic Milieu, Haemogram and Semen Traits of Breeding Stallions.. Biol Trace Elem Res 2021 Sep;199(9):3287-3296.
      doi: 10.1007/s12011-020-02447-7pubmed: 33098077google scholar: lookup
    11. Cappai MG, Dimauro C, Biggio GP, Cherchi R, Accioni F, Pudda F, Boatto G, Pinna W. The metabolic profile of Asinara (albino) and Sardo donkeys (pigmented) (Equus asinus L., 1758) points to unequivocal breed assignment of individuals.. PeerJ 2020;8:e9297.
      doi: 10.7717/peerj.9297pubmed: 32714654google scholar: lookup
    12. Pitel MO, McKenzie EC, Johns JL, Stuart RL. Influence of specific management practices on blood selenium, vitamin E, and beta-carotene concentrations in horses and risk of nutritional deficiency.. J Vet Intern Med 2020 Sep;34(5):2132-2141.
      doi: 10.1111/jvim.15862pubmed: 32686861google scholar: lookup
    13. Bookbinder L, Finno CJ, Firshman AM, Katzman SA, Burns E, Peterson J, Dahlgren A, Ming-Whitfield B, Glessner S, Borer-Matsui A, Valberg SJ. Impact of alpha-tocopherol deficiency and supplementation on sacrocaudalis and gluteal muscle fiber histopathology and morphology in horses.. J Vet Intern Med 2019 Nov;33(6):2770-2779.
      doi: 10.1111/jvim.15643pubmed: 31660648google scholar: lookup
    14. Delesalle C, de Bruijn M, Wilmink S, Vandendriessche H, Mol G, Boshuizen B, Plancke L, Grinwis G. White muscle disease in foals: focus on selenium soil content. A case series.. BMC Vet Res 2017 May 3;13(1):121.
      doi: 10.1186/s12917-017-1040-5pubmed: 28468621google scholar: lookup
    15. Brown JC, Valberg SJ, Hogg M, Finno CJ. Effects of feeding two RRR-u03b1-tocopherol formulations on serum, cerebrospinal fluid and muscle u03b1-tocopherol concentrations in horses with subclinical vitamin E deficiency.. Equine Vet J 2017 Nov;49(6):753-758.
      doi: 10.1111/evj.12692pubmed: 28432750google scholar: lookup
    16. Finno CJ, Kaese HJ, Miller AD, Gianino G, Divers T, Valberg SJ. Pigment retinopathy in warmblood horses with equine degenerative myeloencephalopathy and equine motor neuron disease.. Vet Ophthalmol 2017 Jul;20(4):304-309.
      doi: 10.1111/vop.12417pubmed: 27491953google scholar: lookup
    17. Husulak ML, Lohmann KL, Gabadage K, Wojnarowicz C, Marquu00e9s FJ. Equine motor neuron disease in 2 horses from Saskatchewan.. Can Vet J 2016 Jul;57(7):771-6.
      pubmed: 27429468
    18. Finno CJ, Miller AD, Sisu00f3 S, Divers T, Gianino G, Barro MV, Valberg SJ. Concurrent Equine Degenerative Myeloencephalopathy and Equine Motor Neuron Disease in Three Young Horses.. J Vet Intern Med 2016 Jul;30(4):1344-50.
      doi: 10.1111/jvim.13977pubmed: 27298214google scholar: lookup
    19. Finno CJ, Estell KE, Katzman S, Winfield L, Rendahl A, Textor J, Bannasch DL, Puschner B. Blood and Cerebrospinal Fluid u03b1-Tocopherol and Selenium Concentrations in Neonatal Foals with Neuroaxonal Dystrophy.. J Vet Intern Med 2015 Nov-Dec;29(6):1667-75.
      doi: 10.1111/jvim.13618pubmed: 26391904google scholar: lookup
    20. Xu C, Sun R, Qiao X, Xu C, Shang X, Niu W, Chao Y. Effect of vitamin e supplementation on intestinal barrier function in rats exposed to high altitude hypoxia environment.. Korean J Physiol Pharmacol 2014 Aug;18(4):313-20.
      doi: 10.4196/kjpp.2014.18.4.313pubmed: 25177163google scholar: lookup