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Home / Equine Research Bank / Onderstepoort J Vet Res / A comparative study of the toxicity of Fusarium verticillioi...
The Onderstepoort journal of veterinary research1981; 48(2); 129-131;

A comparative study of the toxicity of Fusarium verticillioides (= F. moniliforme) to horses, primates, pigs, sheep and rats.

Abstract: An isolate of Fusarium verticillioides (MRC826) that induced experimental leukoencephalomalacia, also caused acute toxicity when fed to pigs and administered per rumen fistula to sheep. Pigs developed severe pulmonary oedema while sheep manifested severe nephrosis and hepatosis. A less toxic isolate (F. verticillioides MRC602), fed to baboons, resulted in acute congestive heart failure or hepatic cirrhosis, depending on the dose. Both isolates were toxic to rats and caused similar lesions, namely, hepatic cirrhosis and intraventricular cardiac thrombosis.
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Publication Date: 1981-06-01 PubMed ID: 7312307
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  • Comparative Study
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research focuses on a comparative study of the toxic effects of Fusarium verticillioides (a type of fungus) on multiple species including horses, primates, pigs, sheep, and rats.

Objective and Method of Research

  • The goal of the study was to observe and analyze the varying levels of toxicity of the booleanFusarium verticillioides (MRC826 and MRC602), a fungal pathogen, in different animal species i.e., horses, primates, pigs, sheep, and rats.
  • The two isolates of fungi were introduced to the bodies of these animals either through feeding or a rumen fistula.

Observations and Findings

  • When the animals were exposed to the fungal isolate MRC826, it induced acute toxic results. The pigs developed a serious condition known as pulmonary edema, characterized by excessive fluid in the lungs. The sheep also manifested severe illnesses- nephrosis (kidney damage) and hepatosis (liver disease).
  • A less toxic form of the fungus, Fusarium verticillioides MRC602, was subjected to baboons. Depending on the dose given, the baboons developed acute congestive heart failure or liver cirrhosis. Congestive heart failure is a condition where the heart doesn’t pump blood as well as it should, and liver cirrhosis involves loss of liver cells and irreversible scarring of the liver.
  • All the animals, including rats, showed toxicity when exposed to both the strains of fungi. In rats, the fungi caused hepatic cirrhosis (liver disease) and intraventricular cardiac thrombosis (blood clots inside the chambers of the heart).

Conclusion

  • The study concludes that the Fusarium verticillioides fungus, with differing levels of toxicity, had the ability to induce serious health conditions across multiple animal species.
  • Different animals reacted differently, indicating a range of susceptibility to the fungal attack, with reactions varying from severe pulmonary oedema and nephrosis to heart failure and cirrhosis.

Cite This Article

APA
Kriek NP, Kellerman TS, Marasas WF. (1981). A comparative study of the toxicity of Fusarium verticillioides (= F. moniliforme) to horses, primates, pigs, sheep and rats. Onderstepoort J Vet Res, 48(2), 129-131.

Publication

The Onderstepoort journal of veterinary research
ISSN: 0030-2465
NlmUniqueID: 0401107
Country: South Africa
Language: English
Volume: 48
Issue: 2
Pages: 129-131

Researcher Affiliations

Kriek, N P
    Kellerman, T S
      Marasas, W F

        MeSH Terms

        • Animals
        • Fusarium / pathogenicity
        • Horses
        • Papio
        • Rats
        • Sheep
        • Swine
        • Virulence

        Citations

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