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Veterinary research communications2006; 31(1); 53-65; doi: 10.1007/s11259-006-3402-5

A field study on the effect of some anthelmintics on cyathostomins of horses in sweden.

Abstract: The objective of the study was to investigate different aspects on the efficacy of three anthelmintics on cyathostomin nematodes of Swedish horses. A faecal egg count reduction (FECR) test was performed on 26 farms. Horses were treated orally with recommended doses of ivermectin, pyrantel pamoate or fenbendazole. Faecal samples were collected on the day of deworming and 7, 14 and 21 days later. No resistance was shown against ivermectin; the FECR was constantly >99%. The effect of pyrantel was assessed as equivocal in 6 farms 14 days after treatment; the mean FECR was 99%. As many as 72% of the fenbendazole-treated groups met the criteria for resistance; the mean FECR was 86%, ranging from 56% to 100%. A re-investigation of two farms where pyrantel resistance had been suspected clearly revealed unsatisfactory efficacy of pyrantel on one of these farms; the FECR varied from 72% to 89%. Twenty-six of the horses previously dosed with pyrantel or fenbendazole, and which still excreted >/=150 eggs per gram of faeces 14 days after treatment, were dewormed with ivermectin and fenbendazole or pyrantel in order to eliminate the remaining cyathostomins. A total of 13 cyathostomin species were identified from horses that initially received fenbendazole and seven species were identified from pyrantel-treated individuals. The egg reappearance period (ERP) following treatment with ivermectin and pyrantel was investigated on two farms. The shortest ERP after ivermectin treatment was 8 weeks and after pyrantel was 5 weeks. We conclude that no substantial reversion to benzimidazole susceptibility had taken place, although these drugs have scarcely been used (<5%) in horses for the last 10 years. Pyrantel-resistant populations of cyathostomins are present on Swedish horse farms, but the overall efficacy of pyrantel is still acceptable.
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Publication Date: 2006-12-20 PubMed ID: 17186406DOI: 10.1007/s11259-006-3402-5Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigates the effectiveness of three de-worming medications (ivermectin, pyrantel pamoate or fenbendazole) on a type of parasitic nematode (cyathostomins) in Swedish horses. The research found a high level of resistance to fenbendazole among the parasites, more variable responses to pyrantel pamoate, and no resistance to ivermectin.

Methodology

  • The research was carried out on 26 Swedish farms, examining the faecal egg count reduction (FECR) in horses who were given an oral dosage of the target medicines.
  • The researchers collected faecal samples from these horses on the day of deworming, as well as after 7, 14, and 21 days, to assess the effectiveness of the anthelmintics over time.

Findings

  • The study found no resistance to the drug ivermectin, consistently reducing the FECR by more than 99%.
  • For pyrantel pamoate, the mean FECR was 99%, and it was assessed as equivocal on 6 farms 14 days after treatment.
  • Fenbendazole was reported as being significantly less effective, with up to 72% of the treated groups meeting the criteria for resistance. Its mean FECR was 86%, with a range of 56% to 100%.

Reinvestigation and Follow-Up

  • The researchers revisited two farms where pyrantel resistance had been suspected, confirming unsatisfactory efficacy in clearing the parasitic nematodes at one of these farms.
  • Horses that still excreted a high number of eggs (indicating the presence of cyathostomins) 14 days after treatment with pyrantel or fenbendazole were also given ivermectin; this method was found to be effective in eliminating the remaining parasites.
  • A total of 13 cyathostomin species were identified among horses initially treated with fenbendazole and seven species from pyrantel-treated individuals.

Study Conclusions

  • The research concluded revealed that the use of benzimidazole-based drugs (like fenbendazole) did not significantly revert to its susceptibility, even though these drugs had been used rarely (<5%) for horse deworming over the past decade.
  • Pyrantel-resistant populations of cyathostomins were identified on Swedish horse farms, but the overall efficacy of pyrantel is deemed still acceptable.

Cite This Article

APA
Lind EO, Kuzmina T, Uggla A, Waller PJ, Höglund J. (2006). A field study on the effect of some anthelmintics on cyathostomins of horses in sweden. Vet Res Commun, 31(1), 53-65. https://doi.org/10.1007/s11259-006-3402-5

Publication

Veterinary research communications
ISSN: 0165-7380
NlmUniqueID: 8100520
Country: Switzerland
Language: English
Volume: 31
Issue: 1
Pages: 53-65

Researcher Affiliations

Lind, E Osterman
  • Department of Parasitology, Swedish University of Agricultural Sciences and National Veterinary Institute, Uppsala, Sweden. eva.osterman-lind@sva.se
Kuzmina, T
    Uggla, A
      Waller, P J
        Höglund, J

          MeSH Terms

          • Animals
          • Anthelmintics / therapeutic use
          • Drug Resistance
          • Feces / parasitology
          • Fenbendazole / therapeutic use
          • Horses
          • Ivermectin / therapeutic use
          • Parasite Egg Count / veterinary
          • Prevalence
          • Pyrantel Pamoate / therapeutic use
          • Strongyle Infections, Equine / drug therapy
          • Strongyle Infections, Equine / epidemiology
          • Strongyle Infections, Equine / parasitology
          • Strongylus / growth & development
          • Sweden / epidemiology

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