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Animals : an open access journal from MDPI2022; 12(19); 2581; doi: 10.3390/ani12192581

A Novel A > G Polymorphism in the Intron 1 of LCORL Gene Is Significantly Associated with Hide Weight and Body Size in Dezhou Donkey.

Abstract: Several studies have shown the association between the ligand-dependent nuclear receptor compression-like protein (LCORL) gene and body size in horses, pigs and donkeys. Based on previous studies, the LCORL gene was hypothesized to be associated with growth traits and hide weight in Dezhou donkeys. In this study, we aimed to reveal the variation of the LCORL gene in the Dezhou donkey and explore whether the gene is associated with hide weight and body size. In this study, genetic polymorphisms in the LCORL gene of the Dezhou donkey were studied using targeted sequencing technology, and single nucleotide polymorphisms (SNPs) of the LCORL gene were analyzed for association with hide weight and body size in Dezhou donkeys. The results showed that there was an SNP locus situated in intron 1 of the LCORL gene. Association analysis revealed that individuals with the GG genotype had significantly higher body height, body length, chest circumference and hide weight than those with the AA genotype (p G locus can be used as a potential candidate marker affecting body size and hide weight. This study provides the foundation for breeding high-quality donkeys with high hide yield.
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Publication Date: 2022-09-27 PubMed ID: 36230323PubMed Central: PMC9559650DOI: 10.3390/ani12192581Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research explores how a single variation in the LCORL gene of Dezhou donkeys may affect their body size and hide weight, seeing individuals with a specific genotype having larger body size and heavier hide.

Introduction

Rare genetic variants in the ligand-dependent nuclear receptor compression-like protein (LCORL) gene have previously been associated with body size in various animals such as horses, pigs, and donkeys. The researchers hypothesized that this gene could also be associated with growth traits and hide weight in Dezhou donkeys, a specific breed of donkey native to China.

Methodology

This study used targeted sequencing technology to study the polymorphisms – variations of a particular DNA sequence – in the LCORL gene of Dezhou donkeys.

  • With the use of single nucleotide polymorphisms (SNPs) – a substitution of one nucleotide that occurs at a specific position in the genome – the variations of the LCORL gene were studied and examined in relation to hide weight and body size in donkeys.

Results

The research found that a particular SNP spot identified as ‘g.112558859 A > G’ and located in the first intron of the LCORL gene was significant.

  • Further analysis showed that individuals with the GG genotype – genetic composition at that SNP site – had significantly larger body height, length, and chest circumference as well as heavier hide weight than those with the AA genotype.
  • The difference was deemed to be statistically significant as it was less than 0.05 p-value (a measure of statistical significance).

Conclusion

Based on these findings, the researchers suggested that the ‘g.112558859 A > G’ locus may serve as a key marker for identifying and breeding Dezhou donkeys with high potential for larger body size and hide weight. This discovery provides new insights and potential strategies for breeding high-quality donkeys while increasing hide yield.

Cite This Article

APA
Wang T, Shi X, Liu Z, Ren W, Wang X, Huang B, Kou X, Liang H, Wang C, Chai W. (2022). A Novel A > G Polymorphism in the Intron 1 of LCORL Gene Is Significantly Associated with Hide Weight and Body Size in Dezhou Donkey. Animals (Basel), 12(19), 2581. https://doi.org/10.3390/ani12192581

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 12
Issue: 19
PII: 2581

Researcher Affiliations

Wang, Tianqi
  • Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Agricultural Science and Engineering School, Liaocheng University, Liaocheng 252059, China.
Shi, Xiaoyuan
  • Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Agricultural Science and Engineering School, Liaocheng University, Liaocheng 252059, China.
Liu, Ziwen
  • Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Agricultural Science and Engineering School, Liaocheng University, Liaocheng 252059, China.
Ren, Wei
  • Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Agricultural Science and Engineering School, Liaocheng University, Liaocheng 252059, China.
Wang, Xinrui
  • Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Agricultural Science and Engineering School, Liaocheng University, Liaocheng 252059, China.
Huang, Bingjian
  • Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Agricultural Science and Engineering School, Liaocheng University, Liaocheng 252059, China.
Kou, Xiyan
  • Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Agricultural Science and Engineering School, Liaocheng University, Liaocheng 252059, China.
Liang, Huili
  • Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Agricultural Science and Engineering School, Liaocheng University, Liaocheng 252059, China.
Wang, Changfa
  • Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Agricultural Science and Engineering School, Liaocheng University, Liaocheng 252059, China.
Chai, Wenqiong
  • Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Agricultural Science and Engineering School, Liaocheng University, Liaocheng 252059, China.

Conflict of Interest Statement

The authors declare no conflict of interest.

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