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Home / Equine Research Bank / Front Vet Sci / A Novel Approach to Minimising Acute Equine Endometritis Tha...
Frontiers in veterinary science2022; 8; 799619; doi: 10.3389/fvets.2021.799619

A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State.

Abstract: One of the most commonly encountered challenges in equine breeding is endometritis, which can be difficult to resolve and causes considerable economic losses to the industry. It is a multifactorial condition, developing as an exaggerated form of the normal physiological response to breeding. Seminal plasma proteins, spermatozoa, bacteria and debris initiate an inflammatory response; the resulting fluid and neutrophils are then cleared from the uterus along with the debris. However, in some mares, the response is prolonged or exaggerated, with much fluid formation and neutrophil infiltration leading to acute endometritis. A bacterial cause has been implicated, although in some cases no pathogenic organisms can be isolated on culture. It has been postulated that any one of a variety of bacteria could be involved, or dysbiosis of the uterine microbiome could be responsible. Repeated episodes of acute endometritis may lead to the pathology associated with chronic endometritis, with mucociliary dysfunction, vascular degeneration and plasma cell infiltration. This review examines the information that is currently available about equine endometritis, particularly about the role of the inseminate in the uterus, and its current treatment. There are some promising lines of research into treatment or prevention that may help to resolve the issue.
Copyright © 2022 Morrell and Rocha.
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Publication Date: 2022-01-06 PubMed ID: 35071389PubMed Central: PMC8770823DOI: 10.3389/fvets.2021.799619Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses a proposed novel approach to limiting acute endometritis in horses, in hopes of preventing the development of a chronic condition. The paper reviews current knowledge on the topic, existing treatment methods and promising research lines that may prove useful in resolving issues with endometritis.

About Equine Endometritis

  • Endometritis is a significant challenge in the breeding of horses owing to its complexity and propensity to cause economic losses within the equine industry.
  • Essentially, endometritis is a heightened form of the normal physiological reaction to the breeding process in horses. The substances involved in the breeding process, such as seminal plasma proteins, sperm cells, bacteria, and debris, trigger an inflammatory response. The subsequent fluid and neutrophils are intended to clear the uterus from debris.
  • In some situations, the inflammatory response is either extended or amplified, which results in an excessive production of fluid and inflammation known as acute endometritis.

Causes of Equine Endometritis

  • Although bacteria have been hinted at as a potential cause, there are instances where no pathogenetic organisms can be isolated and identified. The paper suggests the involvement of a variety of bacteria, or that an imbalance in the uterine microbiome may be causing the condition.
  • When acute endometritis frequently recurs, it may evolve into chronic endometritis, manifesting in complications such as mucociliary dysfunction, vascular degeneration, and plasma cell penetration.

Current Treatment and Future Directions

  • The research paper also delves into the current treatments available for equine endometritis and discusses the role of the inseminate in the equine uterus.
  • There are ongoing research efforts toward finding a treatment or a preventive measure that could help in addressing this pervasive issue.

Cite This Article

APA
Morrell JM, Rocha A. (2022). A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State. Front Vet Sci, 8, 799619. https://doi.org/10.3389/fvets.2021.799619

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 8
Pages: 799619
PII: 799619

Researcher Affiliations

Morrell, J M
  • Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Rocha, A
  • Department of Immuno-Physiology and Pharmacology, Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal.
  • Centro de Estudos de Ciência Animal, University of Porto, Porto, Portugal.

Conflict of Interest Statement

JM is the inventor and one of the patent holders of the colloid mentioned in this review. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Citations

This article has been cited 5 times.
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