A one-health perspective: use of hemoderivative regenerative therapies in canine and equine patients.
Abstract: Regenerative medicine therapies have become significant tools for treatment of joint, soft tissue, and a variety of other conditions in animals and humans. Regenerative medicine aims to restore form and function of injured tissues using the body's own resources such as cells, fluids (ie, plasma and serum), and their resulting anti-inflammatory and prohealing cytokines. Platelet-rich plasma and other hemoderivatives have application for joint disorders such as osteoarthritis, cartilage injury, synovitis, and soft tissue injuries. These therapies achieve anti-inflammatory and healing effects without the use of corticosteroid therapy. This response is an advantage when treating young animals or human patients, and in animals with metabolic or hormonal issues such as equine pituitary pars intermedia dysfunction. Also, these therapies may have beneficial effects when traditional IA treatments such as corticosteroids and/or hyaluronan are no longer effective at reducing joint inflammation and pain. Examples of hemoderivative regenerative therapies to be discussed include platelet-rich plasma, autologous conditioned serum, autologous protein solution, and α-2 macroglobulin.
Publication Date: 2023-02-02 PubMed ID: 36735505DOI: 10.2460/javma.22.12.0556Google Scholar: Lookup
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- Journal Article
Summary
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The research article focuses on the use of regenerative medicine therapies, particularly hemoderivative types, in treating various conditions such as joint and soft tissue disorders in animals like dogs and horses.
Regenerative Medicine Therapies
- Regenerative medicine therapies are medical procedures that utilize the body’s own cells, fluids, and cytokines to restore the form and function of injured tissues. This research is particularly focused on hemoderivative therapies which involve the use of blood products.
- These therapies have found extensive application in treating joint disorders such as osteoarthritis, cartilage injury, synovitis, and soft tissue injuries. They work by achieving anti-inflammatory and healing effects without resorting to corticosteroid therapies.
Benefits of Hemoderivative Therapies
- The use of these therapies presents a distinct advantage when treating young animals as well as those with certain metabolic or hormonal issues like equine pituitary pars intermedia dysfunction.
- Hemoderivative therapies might also be effective when traditional Intra-Articular (IA) treatments, such as corticosteroids and hyaluronan, aren’t successful in reducing joint inflammation and pain.
Examples of Hemoderivative Regenerative Therapies
- The article presents various types of hemoderivative regenerative therapies. These include platelet-rich plasma, autologous conditioned serum, autologous protein solution, and α-2 macroglobulin.
- These therapies emphasize the harnessing of the body’s own healing capabilities, promising fewer complications and potential long-term healing effects.
Cite This Article
APA
Kaneps AJ.
(2023).
A one-health perspective: use of hemoderivative regenerative therapies in canine and equine patients.
J Am Vet Med Assoc, 261(3), 301-308.
https://doi.org/10.2460/javma.22.12.0556 Publication
Researcher Affiliations
- Kaneps Equine Sports Medicine and Surgery LLC, Beverly, MA.
MeSH Terms
- Humans
- Animals
- Dogs
- Horses
- One Health
- Osteoarthritis / veterinary
- Pain / veterinary
- Wound Healing
- Platelet-Rich Plasma / metabolism
- Anti-Inflammatory Agents
- Dog Diseases
- Horse Diseases
Citations
This article has been cited 4 times.- Banu SA, Sharun K, Emmanuel RS, Mamachan M, Manjusha KM, Muthu S, El-Husseiny HM, Kumar R, Pawde AM, Dhama K, Amarpal. Stem Cell Exosomes for Osteoarthritis in Veterinary Medicine. Stem Cells Int 2025;2025:4888569.
- Marcellin-Little DJ, Hulse DA, Huntingford JL, Grubb T, Brunke MW, Markley AP, Frank B. A proposed framework for practical multimodal management of osteoarthritis in growing dogs. Front Vet Sci 2025;12:1565922.
- Ospina J, Carmona JU, López C. Short-Term Effects of Two COX-2 Selective Non-Steroidal Anti-Inflammatory Drugs on the Release of Growth Factors and Cytokines from Canine Platelet-Rich Gel Supernatants. Gels 2024 Jun 12;10(6).
- Reis IL, Lopes B, Sousa P, Sousa AC, Caseiro AR, Mendonça CM, Santos JM, Atayde LM, Alvites RD, Maurício AC. Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives-A Review. Vet Sci 2024 Apr 26;11(5).
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