A retrospective study on methicillin-resistant Staphylococcus spp. isolated from horses admitted to a Canadian veterinary teaching hospital between 2008 and 2018.
Abstract: The goals of this retrospective study were to: determine the frequency of methicillin-resistant Staphylococcus spp. (MRS) isolated from horses admitted to an equine veterinary teaching hospital in Quebec from 2008 to 2018, investigate the patterns of antimicrobial resistance (AMR), and evaluate the distribution of MRS and methicillin-sensitive Staphyloccocus spp. (MSS) by body site. During this period, 311 Staphylococcus spp. were isolated from 273 horses and 127 of these isolates were submitted to antimicrobial susceptibility testing. Of these 127 isolates, 24 (18.9%) were MRS, and among the S. aureus (n = 76), 19 (25%) were MRS. The odds of detecting an MRS increased (25%) each year [95% confidence interval (CI) (1% to 55%), P = 0.039]. The highest frequencies of resistance were to tetracycline and gentamicin. Among the MRS isolates, 12% were susceptible to both tetracycline and gentamicin. The most frequently sampled body sites were "soft-tissues." There was no significant difference (P = 0.93) in the body site distribution of MRS and MSS isolates. Étude rétrospective sur les Staphylococcus spp. résistants à la méthicilline isolés de chevaux admis à un hôpital d’enseignement vétérinaire au Canada entre 2008 et 2018. Les buts de cette étude rétrospective étaient : déterminer la fréquence de Staphylococcus spp. résistants à la méthicilline (MRS) isolés de chevaux admis à un hôpital d’enseignement vétérinaire au Québec entre 2008 et 2018, étudier les patrons de résistance aux antimicrobiens (AMR) et évalué la distribution de MRS et de Staphylococcus spp, sensible à la méthicilline (MSS) par site corporel. Durant la période visée, 311 Staphylococcus spp. furent isolés de 273 chevaux et 127 de ces isolats furent soumis à un test de sensibilité aux antimicrobiens. De ces 127 isolats, 24 (18,9 %) étaient de MRS, et parmi les S. aureus (n = 76), 19 (25 %) étaient des MRS. Les probabilités de détecter un MRS augmentaient (25 %) chaque année [intervalle de confiance 95 % (CI) (1 % à 55 %), P = 0,039]. Les fréquences les plus élevées de résistance étaient envers la tétracycline et la gentamycine. Parmi les isolats de MRS, 12 % étaient sensibles à la tétracycline et à la gentamycine. Les sites corporels les plus souvent échantillonnés étaient les « tissus mous ». Il n’y avait pas de différence significative (P = 0,93) entre les MRS et les MSS en ce qui a trait à la distribution selon les sites corporels.(Traduit par Dr Serge Messier).
Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.
Publication Date: 2020-11-06 PubMed ID: 33149358PubMed Central: PMC7560767
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- Journal Article
Summary
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The study investigates the frequency of methicillin-resistant Staphylococcus spp. found in horses at a Canadian veterinary hospital over a decade and studies patterns of resistance to various antibiotics. It found a steady increase in methicillin-resistance in this bacterial sample over the period of study.
Research Background
- This was a retrospective study examining the presence of methicillin-resistant Staphylococcus spp. (MRS) in horses from a Quebec-based veterinary teaching hospital from 2008 to 2018.
Research Aims
- The research aimed to identify the frequency of MRS, the patterns of antimicrobial resistance in these bacteria, and the distribution of MRS and methicillin-sensitive Staphylococcus spp. (MSS) in different body sites of the horses.
Research Findings
- During the study period, the researchers isolated 311 Staphylococcus spp. from 273 horses.
- Of these, 127 were submitted to antimicrobial susceptibility testing.
- Out of these 127, 24 (18.9%) were found to be MRS. Within the Staphylococcus aureus subset (76 individuals), 19 (25%) were identified as MRS.
- An important finding was that the likelihood of finding an MRS sample increased by 25% each year. This increase was within a range of growth in resistance from 1% to 55%.
Additional Observations
- The bacteria showed all-time high resistance to tetracycline and gentamicin antibiotics.
- Only 12% of the MRS isolates were susceptible to both these antibiotics.
- The most frequent body sites from which samples were collected were ‘soft-tissues’. There was no notable difference in MRS and MSS distribution within sampled body sites.
This research is significant as it identifies a concerning trend of increasing bacterial resistance to certain antibiotics. The results could influence future treatment protocols regarding antimicrobial therapy in horses.
Cite This Article
APA
Roudaud M, Allano M, Fairbrother JH, Sauvé F.
(2020).
A retrospective study on methicillin-resistant Staphylococcus spp. isolated from horses admitted to a Canadian veterinary teaching hospital between 2008 and 2018.
Can Vet J, 61(11), 1197-1202.
Publication
Researcher Affiliations
- Département de sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, 3200, rue Sicotte, Saint-Hyacinthe, Québec J2S 2M2 (Roudaud, Allano, Sauvé); Bacteriology Diagnostic Laboratory, Complexe de Diagnostic et d'Épidémiosurveillance Vétérinaires du Québec, Ministère de l'Agriculture, des Pêcheries et de l'Alimentation du Québec and Faculté de médecine vétérinaire, Université de Montréal, 3220, rue Sicotte, Saint-Hyacinthe, Québec J2S 2M2 (Fairbrother).
- Département de sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, 3200, rue Sicotte, Saint-Hyacinthe, Québec J2S 2M2 (Roudaud, Allano, Sauvé); Bacteriology Diagnostic Laboratory, Complexe de Diagnostic et d'Épidémiosurveillance Vétérinaires du Québec, Ministère de l'Agriculture, des Pêcheries et de l'Alimentation du Québec and Faculté de médecine vétérinaire, Université de Montréal, 3220, rue Sicotte, Saint-Hyacinthe, Québec J2S 2M2 (Fairbrother).
- Département de sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, 3200, rue Sicotte, Saint-Hyacinthe, Québec J2S 2M2 (Roudaud, Allano, Sauvé); Bacteriology Diagnostic Laboratory, Complexe de Diagnostic et d'Épidémiosurveillance Vétérinaires du Québec, Ministère de l'Agriculture, des Pêcheries et de l'Alimentation du Québec and Faculté de médecine vétérinaire, Université de Montréal, 3220, rue Sicotte, Saint-Hyacinthe, Québec J2S 2M2 (Fairbrother).
- Département de sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, 3200, rue Sicotte, Saint-Hyacinthe, Québec J2S 2M2 (Roudaud, Allano, Sauvé); Bacteriology Diagnostic Laboratory, Complexe de Diagnostic et d'Épidémiosurveillance Vétérinaires du Québec, Ministère de l'Agriculture, des Pêcheries et de l'Alimentation du Québec and Faculté de médecine vétérinaire, Université de Montréal, 3220, rue Sicotte, Saint-Hyacinthe, Québec J2S 2M2 (Fairbrother).
MeSH Terms
- Animals
- Anti-Bacterial Agents / pharmacology
- Canada / epidemiology
- Horse Diseases / epidemiology
- Horses
- Hospitals, Animal
- Hospitals, Teaching
- Methicillin Resistance
- Methicillin-Resistant Staphylococcus aureus
- Microbial Sensitivity Tests / veterinary
- Quebec
- Retrospective Studies
- Staphylococcal Infections / drug therapy
- Staphylococcal Infections / epidemiology
- Staphylococcal Infections / veterinary
- Staphylococcus
- Staphylococcus aureus
References
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