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Veterinary sciences2024; 11(10); doi: 10.3390/vetsci11100480

A Review of Epithelial Ion Transporters and Their Roles in Equine Infectious Colitis.

Abstract: Equine colitis is a devastating disease with a high mortality rate. Infectious pathogens associated with colitis in the adult horse include Clostridioides difficile, Clostridium perfringens, Salmonella spp., Neorickettsia risticii/findlaynesis, and equine coronavirus. Antimicrobial-associated colitis can be associated with the presence of infectious pathogens. Colitis can also be due to non-infectious causes, including non-steroidal anti-inflammatory drug administration, sand ingestion, and infiltrative bowel disease. Current treatments focus on symptomatic treatment (restoring fluid and electrolyte balance, preventing laminitis and sepsis). Intestinal epithelial ion channels are key regulators of electrolyte (especially sodium and chloride) and water movement into the lumen. Dysfunctional ion channels play a key role in the development of diarrhea. Infectious pathogens, including Salmonella spp. and C. difficile, have been shown to regulate ion channels in a variety of ways. In other species, there has been an increased interest in ion channel manipulation as an anti-diarrheal treatment. While targeting ion channels also represents a promising way to manage diarrhea associated with equine colitis, ion channels have not been well studied in the equine colon. This review provides an overview of what is known about colonic ion channels and their known or putative role in specific types of equine colitis due to various pathogens.
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Publication Date: 2024-10-07 PubMed ID: 39453072PubMed Central: PMC11512231DOI: 10.3390/vetsci11100480Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article focuses on understanding the role of epithelial ion transporters in equine infectious colitis, a deadly disease in horses often caused by various infectious pathogens as well as non-infectious causes like drug administration and bowel disease.

Understanding Epithelial Ion Transporters and Equine Infectious Colitis

  • This research analyzes equine colitis, a severe disease in horses that has a significant fatality rate. Essentially, it makes a deep dive into the causes of the disease, pointing to both infectious pathogens and non-infectious triggers as potential instigators.
  • Pathogens highlighted in the article associated with adult horse colitis include , , spp., /, and equine coronavirus. On the other hand, non-infectious causes, as shown in the review, encompass non-steroidal anti-inflammatory drug administration, sand ingestion, and infiltrative bowel disease.
  • As per the article, current treatment strategies tend to focus on symptomatic management, such as restoring fluid and electrolyte balance and preventing complications like laminitis and sepsis.

Relevance of Intestinal Epithelial Ion Channels in Equine Infectious Colitis

  • As outlined in the article, intestinal epithelial ion channels play a crucial role in the movement of electrolytes, particularly sodium and chloride, and water into the lumen, which is the inner open space or cavity of a tubular organ such as the intestine. Dysfunctions of these ion channels, therefore, can lead to diarrhea, a key sign of colitis.
  • Interestingly, the research also reveals that certain infectious pathogens can control these ion channels in different ways, further contributing to the manifestation of diarrhea.

Ideal Vector for Anti-Diarrheal Treatment

  • In other animal species, ion channels have received growing attention as potential targets for anti-diarrheal treatment. The review suggests that these channels can also be a viable way to manage diarrhea related to equine colitis.
  • However, the research highlights that ion channels in the equine colon havn’t been comprehensively researched, pointing out a significant gap in understanding and treating equine colitis.
  • The overreaching aim of this review is to offer an insight into what is known about colonic ion channels and their direct or indirect role in the various types of equine colitis caused by different pathogens.

Cite This Article

APA
Haywood LMB, Sheahan BJ. (2024). A Review of Epithelial Ion Transporters and Their Roles in Equine Infectious Colitis. Vet Sci, 11(10). https://doi.org/10.3390/vetsci11100480

Publication

Veterinary sciences
ISSN: 2306-7381
NlmUniqueID: 101680127
Country: Switzerland
Language: English
Volume: 11
Issue: 10

Researcher Affiliations

Haywood, Lillian M B
  • Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
Sheahan, Breanna J
  • Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.

Conflict of Interest Statement

The authors declare no conflicts of interest.

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