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Equine veterinary journal2012; 44(6); 752-761; doi: 10.1111/j.2042-3306.2012.00664.x

A review of recent advances and current hypotheses on the pathogenesis of acute laminitis.

Abstract: With the increasing number of studies being published on the different experimental models used to induce and study acute laminitis, the pathophysiological events associated with these various models (i.e. starch overload, oligofructose overload, black walnut extract and hyperinsulinaemia) can be compared more realistically. Within this review, the mechanisms for metabolic vs. inflammatory laminitis are discussed, and the question of how pasture laminitis may fit into any of the proposed mechanisms is addressed.
© 2012 EVJ Ltd.
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Publication Date: 2012-10-31 PubMed ID: 23106629DOI: 10.1111/j.2042-3306.2012.00664.xGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is a comprehensive review of recent experiments and studies focused on understanding the development of acute laminitis in horses and the associated pathophysiological events by using a range of experimental models including starch overload, oligofructose overload, black walnut extract, and hyperinsulinaemia.

Research Background

  • The research provides a detailed analysis of the latest studies and experiments related to the pathogenesis of acute laminitis, a painful condition affecting horses’ feet.
  • The work spotlights a broad spectrum of experimental models being used to induce and investigate acute laminitis, making comparisons between them more plausible.
  • Models discussed include starch overload, oligofructose overload, black walnut extract ingestion, and hyperinsulinaemia (excess insulin in the blood), all of which are linked to acute laminitis in horses.

Metabolic vs Inflammatory Laminitis

  • One significant part of the research discusses the mechanisms for metabolic and inflammatory laminitis, two different forms of the disease.
  • Metabolic laminitis is generally associated with obesity and systemic insulin resistance. A horse suffering from this form of laminitis indicates a significant metabolic disorder that exacerbates the regulation of insulin, leading to a painful inflammation in the hooves.
  • Inflammatory laminitis, on the other hand, is usually triggered by infection or injury and is characterized by a sudden inflammation in the laminae, the sensitive layers inside a horse’s hoof.

Pasture Laminitis

  • The research also investigates how pasture laminitis relates to the proposed mechanisms.
  • Pasture laminitis refers to the form of the disease that tends to occur in horses turned out on pasture, especially in terrains rich in certain types of grasses that can overload the horse’s system with more sugars than it can process smoothly.
  • The question of how this fits into the mechanisms of metabolic or inflammatory laminitis is an essential aspect of the research, as understanding the pathogenesis of acute laminitis will help in its prevention and treatment.

Cite This Article

APA
Katz LM, Bailey SR. (2012). A review of recent advances and current hypotheses on the pathogenesis of acute laminitis. Equine Vet J, 44(6), 752-761. https://doi.org/10.1111/j.2042-3306.2012.00664.x

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 44
Issue: 6
Pages: 752-761

Researcher Affiliations

Katz, L M
  • School of Veterinary Medicine, University College Dublin, Dublin, Ireland. lisa.katz@ucd.ie
Bailey, S R

    MeSH Terms

    • Acute Disease
    • Animals
    • Foot Diseases / complications
    • Foot Diseases / pathology
    • Foot Diseases / veterinary
    • Hoof and Claw / pathology
    • Horse Diseases / etiology
    • Horse Diseases / pathology
    • Horses
    • Inflammation / complications
    • Inflammation / pathology
    • Inflammation / veterinary

    Citations

    This article has been cited 21 times.
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