A Systematic Literature Review of Complementary and Alternative Veterinary Medicine: Laser Therapy.
Abstract: Light therapy, or photobiomodulation, is a collective name for methods where tissue is irradiated with different types of light, with the aim of stimulating healing. Despite being frequently used, there is no consensus regarding the optimal treatment protocols for light therapy, nor its clinical efficacy. A systematic literature review was conducted, searching the relevant literature regarding light therapy in three databases, published between 1980-2020. The risk of bias in each article was evaluated. Forty-five articles met the inclusion criteria; 24 articles were regarding dogs, 1 was regarding cats, and the rest were regarding horses. The indications for treatment were musculoskeletal and neurologic conditions, skin disease and wounds, and pain. The literature review showed conflicting study results and unclear application for clinical use. This can be explained by the wide variety of treatment parameters used in the searched studies, such as wavelength, laser class, dose, and effect, as well as the frequency and duration of treatment. Although some beneficial effects were reported for light therapy, the studies also had limited scientific quality regarding these therapies, with a high or moderate risk of bias.
Publication Date: 2023-02-14 PubMed ID: 36830454PubMed Central: PMC9951699DOI: 10.3390/ani13040667Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article reviews existing literature on light therapy in veterinary medicine, known as photobiomodulation, to determine its optimal protocols and clinical efficacy. Despite frequent usage, the review found diverse and conflicting results due to varying treatment parameters, thereby complicating its applicability in a clinical setting.
Objective and Methodology
- The study aimed to investigate the effectiveness and best treatment process regarding light therapy in veterinary medicine by conducting a systematic literature review.
- The authors searched three different databases for relevant literature published between 1980 and 2020.
- A critical examination was conducted that assessed the risk of bias in each article in order to ensure a credible and comprehensive review.
Scope of Reviewed Literature
- Out of the valid literature, 45 articles met the inclusion criteria and were subsequently analyzed for their findings and methodologies.
- The majority of the articles (24 out of 45) were related to use of light therapy in dogs, one catered to cats, while the rest studied its application in horses.
- The medical conditions that were most often treated with light therapy were musculoskeletal and neurological conditions, skin disease and wounds, and pain.
Summary of Findings
- The outcome of the literature review was not linear. Differing results were found across various studies demonstrating unclear usage of photobiomodulation in a clinical context.
- The inconsistency in results and clinical application can be attributed to the diverse set of treatment parameters employed by the various studies. Such as wavelength, laser class, dosage, effect, frequency, and duration of treatment.
- Some beneficial effects of light therapy were observed; however, these positive results were overshadowed by the limited scientific quality of the studies. Most research in the review had a high to moderate risk of bias.
Cite This Article
APA
Millis DL, Bergh A.
(2023).
A Systematic Literature Review of Complementary and Alternative Veterinary Medicine: Laser Therapy.
Animals (Basel), 13(4).
https://doi.org/10.3390/ani13040667 Publication
Researcher Affiliations
- Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
- Department of Clinical Sciences, Swedish University of Agricultural Sciences, SE 750 07 Uppsala, Sweden.
Grant Funding
- SLU.ua.2020.4.2-3148 / Swedish university of agricultural sciences, SLU Future One Health
Conflict of Interest Statement
The authors declare no conflict of interest.
References
This article includes 53 references
- Liebert A, Kiat H. The history of light therapy in hospital physiotherapy and medicine with emphasis on Australia: Evolution into novel areas of practice.. Physiother. Theory Pract. 2021;37:389–400.
- Pryor B, Millis DL. Therapeutic Laser in Veterinary Medicine.. Vet. Clin. N. Am. Small Anim. Pract. 2015;45:45–56.
- Avci P, Gupta A, Sadasivam M, Vecchio D, Pam Z, Pam N, Hamblin MR. Low-level laser (light) therapy (LLLT) in skin: Stimulating, healing, restoring.. Semin. Cutan. Med. Surg. 2013;32:41–52.
- Higgins J, Thomas J. Cochrane Handbook for Systematic Reviews of Interventions.. John Wiley & Sons; Hoboken, NJ, USA: 2021.
- . SBU:s Metodbok 2022.. Statens Beredning för Medicinsk och Social Utvärdering [SBU] 2022.
- Looney AL, Huntingford JL, Blaeser LL, Mann S. A randomized blind placebo-controlled trial investigating the effects of photobiomodulation therapy (PBMT) on canine elbow osteoarthritis.. Can. Vet. J. 2018;59:959–966.
- Rogatko CP, Baltzer WI, Tennant R. Preoperative low level laser therapy in dogs undergoing tibial plateau levelling osteotomy: A blinded, prospective, randomized clinical trial.. Vet. Comp. Orthop. Traumatol. 2017;30:46–53.
- Renwick AI, Brodbelt DC, Ferguson J, Abreu H. Influence of class IV laser therapy on the outcomes of tibial plateau leveling osteotomy in dogs.. Vet. Surg. 2018;47:507–515.
- Kennedy KC, Martinez SA, Martinez SE, Tucker RL, Davies NM. Effects of low-level laser therapy on bone healing and signs of pain in dogs following tibial plateau leveling osteotomy.. Am. J. Vet. Res. 2018;79:893–904.
- Santiago V, Piram A, Fuziy A. Effect of soft laser in bone repair after expansion of the midpalatal suture in dogs.. Am. J. Orthod. Dentofac. Orthop. 2012;142:615–624.
- Wozniak P, Brzeski W, Chyczewski M, Jalynski M. The influence of limited strength laser radiation on the effective treatment of dogs with osteomyelitis.. Med. Weter. 1997;53:665–668.
- Lindholm AC, Swensson U, de Mitri N, Collinder E. Clinical effects of betamethasone and hyaluronan, and of defocalized carbon dioxide laser treatment on traumatic arthritis in the fetlock joints of horses.. J. Vet. Med. A Physiol. Pathol. Clin. Med. 2002;49:189–194.
- Bergh A, Nyman G, Roepstorff L, Zhou Q, Hallberg M, Drevemo S, Roethlisberger-Holm K. Defocused CO2 laser therapy in traumatic arthritis of the metacarpophalangeal joint: A randomized clinical study.. Equine Comp. Exerc. Phys. 2006;4:169–177.
- Zielinska P, Nicpon J, Kielbowicz Z, Soroko M, Dudek K, Zaborski D. Effects of high intensity laser therapy in the treatment of tendon and ligament injuries in performance horses.. Animals 2020;8:1327.
- Marr CM, Love S, Boyd JS, McKellar Q. Factors affecting the clinical outcome of injuries to the superficial digital flexor tendon in National Hunt and point-to-point racehorses.. Vet. Rec. 1993;132:476–479.
- Bergh A, Nyman G, Lundeberg T, Drevemo S. Effect of defocused CO2 laser on equine tissue perfusion.. Acta Vet. Scand. 2006;47:33–42.
- Godlewska M, Soroko M, Zielinska P, Dudek K. The use of thermography for assessment of high-intensity laser therapy in racehorses: Pilot study.. Med. Weter.-Vet. Med.-Sci. Pract. 2020;10:593–596.
- Monici M, Gnerucci A, Falconi T, Bani D, Cialdai F, Fusi F, Romano G. Laser therapy penetration depth: A near-infrared study on a horse tendon model.. Muscles Ligaments Tendons J. 2018;8:222–228.
- Gammel JE, Biskup JJ, Drum MG, Newkirk Kim Lux CN. Effects of low-level laser therapy on the healing of surgically closed incisions and surgically created open wounds in dogs.. Vet. Surg. 2018;47:499–506.
- Kurach LM, Stanley BJ, Gazzola KM, Fritz MC, Steficek BA, Hauptman JG, Seymour KJ. The Effect of Low-Level Laser Therapy on the Healing of Open Wounds in Dogs.. Vet. Surg. 2015;44:988–996.
- Debraekt MMHI, Vanalphen FAM, Kuijpersjagtman AM, Maltha JC. Effect of low-level laser therapy on wound-healing after palatal surgery in beagle dogs.. Lasers Surg. Med. 1991;11:462–470.
- Wardlaw JL, Gazzola KM, Wagoner A, Brinkman E, Burt J, Butler R, Gunter JM, Senter LH. Laser Therapy for Incision Healing in 9 Dogs.. Front. Vet. Sci. 2019;5:349.
- Bharti B, Pandey SS, Garg UK, Shukla BP. Low level laser therapy for the healing of contaminated wounds in dogs: Histopathological changes.. Indian J. Vet. Surg. 2013;34:57–58.
- Marchegiani A, Spaterna A, Cerquetella M, Tambella AM, Fruganti A, Paterson A. Fluorescence biomodulation in the management of canine interdigital pyoderma cases: A prospective, single-blinded, randomized and controlled clinical study.. Vet. Dermatol. 2019;30:371.
- Stich AN, Rosenkrantz WS, Griffin CE. Clinical efficacy of low-level laser therapy on localized canine atopic dermatitis severity score and localized pruritic visual analog score in pedal pruritus due to canine atopic dermatitis.. Vet. Dermatol. 2014;25:464.
- Kampa N, Jitpean S, Seesupa S, Hoisang S. Penetration depth study of 830 nm low-intensity laser therapy on living dog tissue.. Vet. World. 2020;7:1417–1422.
- Hochman-Elam LN, Heidel RE, Shmalberg JW. Effects of laser power, wavelength, coat length, and coat color on tissue penetration using photobiomodulation in healthy dogs.. Can. J. Vet. Res. 2020;84:131–137.
- Keerti N, Bhargava MK, Madhu S, Dharmendra K, Bhowmick D. Low level laser therapy for healing of aural haematoma in dogs.. Intas Polivet. 2016;2:262–269.
- Olivieri L, Cavina D, Radicchi G, Miragliotta V, Abramo F. Efficacy of low-level laser therapy on hair regrowth in dogs with noninflammatory alopecia: A pilot study.. Vet. Dermatol. 2015;26:35–39.e11.
- Kaneps AJ, Hultgren BD, Riebold TW, Shires GM. Laser therapy in the horse: Histopathologic response.. Am. J. Vet. Res. 1984;45:581–582.
- Petersen SL, Botes C, Olivier A, Guthrie AJ. The effect of low level laser therapy (LLLT) on wound healing in horses.. Equine Vet. J. 1999;31:228–231.
- Gomez-Villamandos RJ, Santisteban Valenzuela JM, Ruiz Calatrava I, Gomez-Villamandos JC, Avila Jurado I. He-Ne laser therapy by fibroendoscopy in the mucosa of the equine upper airway.. Lasers Surg. Med. 1995;16:184–188.
- Bader OA, Eesa MJ. Treatment of hyper-granulated limb wounds in horses.. Iraqi J. Vet. Sci. 2011;2:71–80.
- Bergh A, Ridderstråle Y, Ekman S. Defocused CO2 laser on equine skin: A histological examination.. Equine Vet. J. 2007;39:114–119.
- Duesterdieck-Zellmer KF, Larson MK, Plant TK, Sundholm-Tepper A, Payton ME. Ex vivo penetration of low-level laser light through equine skin and flexor tendons.. Am. J. Vet. Res. 2016;77:991–999.
- Ryan T, Smith RKW. An investigation into the depth of penetration of low level laser therapy through the equine tendon in vivo.. Ir. Vet. J. 2007;60:295–299.
- Luna SPL, Schoen A, Trindade PHE, Rocha PB. Penetration profiles of a class iv therapeutic laser and a photobiomodulation therapy device in equine skin.. J. Equine Vet. Sci. 2020;85:102846.
- Tomacheuski RM, Taffarel MO, Cardoso GS, Derussi AAP, Ferrante M, Volpato R, Luna SPL. Postoperative analgesic effects of laserpuncture and meloxicam in bitches submitted to ovariohysterectomy.. Vet. Sci. 2020;21:94.
- Nascimento FF, Marques VI, Crociolli GC, Nicação GM, Nicação IPAG, Cassu RN. Analgesic efficacy of laser acupuncture and electroacupuncture in cats undergoing ovariohysterectomy.. J. Vet. Med. Sci. 2019;81:764–770.
- Martin BB Jr, Klide AM. Treatment of chronic back pain in horses. Stimulation of acupuncture points with a low powered infrared laser.. Vet. Surg. 1987;16:106–110.
- Haussler KK, Manchon PT, Donnell JR, Frisbie DD. Effects of low-level laser therapy and chiropractic care on back pain in quarter horses.. J. Equine Vet. Sci. 2020;86:102891.
- Brevault S, Dallongeville E, Geffroy O. Etude de l’efficacite de la therapie laser dans la gestion des dorsalgies du cheval de sport [Study of the effectiveness of laser therapy in the management of dorsalgia in horses]. Prat. Vet. Equine. 2016;191:24–33.
- Petermann U. Comparison of pre- and post-treatment pain scores of twenty one horses with laminitis treated with acupoint and topical low level impulse laser therapy.. Am. J. Tradit. Chin. Vet. Med. 2011;1:13–25.
- Ghazaleh N, Sharifi D, Ghamsari S, Mokmeli S, Rasooli A. Evaluation of low level laser effects on epidural anaesthesia in horse.. Iran. J. Vet. Surg. 2018;1:47–53.
- Bruno E, Canal S, Antonucci M, Bernardini M, Balducci F, Musella V, Mussoni M, Spinella G. Perilesional photobiomodulation therapy and physical rehabilitation in post-operative recovery of dogs surgically treated for thoracolumbar disk extrusion.. BMC Vet. Res. 2020;16:120.
- Bennaim M, Porato M, Jarleton A, Hamon M, Carroll JD, Gommeren K, Balligand M. Preliminary evaluation of the effects of photobiomodulation therapy and physical rehabilitation on early postoperative recovery of dogs undergoing hemilaminectomy for treatment of thoracolumbar intervertebral disk disease.. Am. J. Vet. Res. 2017;78:195–206.
- Williams CC, Barone G. Is low level laser therapy an effective adjunctive treatment to hemilaminectomy in dogs with acute onset parapleglia secondary to intervertebral disc disease?. J. Vet. Int. Med. 2011;25:730–731.
- Draper WE, Schubert TA, Clemmons RM, Miles SA. Low-level laser therapy reduces time to ambulation in dogs after hemilaminectomy: A preliminary study.. J. Small Anim. Pract. 2012;53:465–469.
- Sharifi D, Hadjibekloo AR, Ghamsari SM, Taghvi HR. Evaluation of low level laser effects on muscular ability in dog: An animal model.. J. Fac. Vet. Med. Univ. Tehran. 2005;4:327–331.
- Miller LA, Torraca DG, De Taboada L. Retrospective observational study and analysis of two different photobiomodulation therapy protocols combined with rehabilitation therapy as therapeutic interventions for canine degenerative myelopathy.. Photobiomodul. Photomed. Laser Surg. 2020;38:195–205.
- Song F, Parekh S, Hooper L, Loke YK, Ryder J, Sutton AJ, Hing C, Kwok CS, Pang C, Harvey I. Dissemination and publication of research findings: An updated review of related biases.. Health Technol. Assess. 2010;14:1–193.
- Rücker G, Carpenter JR, Schwarzer G. Detecting and adjusting for small-study effects in meta-analysis.. Biom. J. 2011;53:351–368.
- Saito S, Shimizu N. Stimulatory effects of low-power laser irradiation on bone regeneration in midpalatal suture during expansion in the rat.. Am. J. Orthod. Dentofac. Orthop. 1997;111:525–532.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists