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Home / Equine Research Bank / Vet Clin North Am Equine Pract / Adrenocortical insufficiency in horses and foals.
The Veterinary clinics of North America. Equine practice2011; 27(1); 19-34; doi: 10.1016/j.cveq.2010.12.005

Adrenocortical insufficiency in horses and foals.

Abstract: The adrenal cortices produce various steroid hormones that play vital roles in several physiologic processes. Although permanent adrenocortical insufficiency is rare in all species, emerging evidence in both human and equine medicine suggests that transient reversible adrenocortical dysfunction resulting in cortisol insufficiency frequently develops during critical illness. This syndrome is termed relative adrenal insufficiency (RAI) or critical illness-related corticosteroid insufficiency (CIRCI) and can contribute substantially to morbidity and mortality associated with the primary disease. This review discusses the mechanisms, diagnosis, and clinical consequences of adrenocortical insufficiency, with particular focus on the current understanding of RAI/CIRCI in horses and foals.
Copyright © 2011 Elsevier Inc. All rights reserved.
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Publication Date: 2011-03-12 PubMed ID: 21392651PubMed Central: PMC3073730DOI: 10.1016/j.cveq.2010.12.005Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigates adrenocortical insufficiency, a transient dysfunction resulting in cortisol insufficiency often seen in severe illness, in horses and foals. The researchers discuss the mechanisms, diagnosis, and clinical consequences of the condition, particularly focusing on its role in critically ill equine subjects.

Background on Adrenocortical Insufficiency

  • The adrenocortical glands in the body have the responsibility for creating several types of steroid hormones. These hormones play pivotal roles in many essential physiological processes.
  • Permanent adrenocortical insufficiency, a state where these glands permanently malfunction is a rare occurrence. However, transient reversible adrenocortical dysfunction, often seen during critical illness, appears to be more common and has been observed in both human and equine medicine.

Relative Adrenal Insufficiency and Critical Illness-Related Corticosteroid Insufficiency

  • This transient dysfunction is termed as Relative Adrenal Insufficiency (RAI) or Critical Illness-Related Corticosteroid Insufficiency (CIRCI). This condition can become a significant contributor to the morbidity and mortality associated with the primary disease in critically ill patients.
  • The research is specifically interested in RAI/CIRCI’s presence and effects in horses and foals, an area of study that can significantly impact equine medicine.

Understanding RAI/CIRCI in Horses and Foals

  • The research purports a detailed discussion on the mechanisms, diagnosis procedures, and clinical results of adrenocortical insufficiency. The main focus of the study though is the understanding of RAI/CIRCI in equine subjects, specifically horses and foals.
  • The in-depth investigation into the adrenal insufficiency in horses and foals may unlock breakthroughs on how to treat or prevent the condition, potentially reducing the rates of morbidity and mortality in critically ill equine subjects.

Cite This Article

APA
Hart KA, Barton MH. (2011). Adrenocortical insufficiency in horses and foals. Vet Clin North Am Equine Pract, 27(1), 19-34. https://doi.org/10.1016/j.cveq.2010.12.005

Publication

The Veterinary clinics of North America. Equine practice
ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 27
Issue: 1
Pages: 19-34

Researcher Affiliations

Hart, Kelsey A
  • Department of Large Animal Medicine, University of Georgia College of Veterinary Medicine, 501 DW Brooks Drive, Athens, GA 30602, USA. khart4@uga.edu
Barton, Michelle H

    MeSH Terms

    • Addison Disease / blood
    • Addison Disease / diagnosis
    • Addison Disease / physiopathology
    • Addison Disease / veterinary
    • Adrenal Cortex / metabolism
    • Adrenal Cortex / physiopathology
    • Animals
    • Animals, Newborn
    • Female
    • Horse Diseases / blood
    • Horse Diseases / diagnosis
    • Horse Diseases / physiopathology
    • Horses
    • Hydrocortisone / blood
    • Hydrocortisone / deficiency
    • Male

    Grant Funding

    • F32 GM086003 / NIGMS NIH HHS
    • F32 GM086003-02 / NIGMS NIH HHS

    References

    This article includes 93 references
    1. Gravanis A, Margioris A. Pharmacology of glucocorticoids: An overview.. In: Margioris A, Chrousos G, editors. Contemporary Endocrinology: Adrenal Disorders. Humana Press; Totowa, NJ: 2001.
    2. Alesci S, Koch CA, Bornstein SR, Pacak K. Adrenal androgens regulation and adrenopause.. Endocr Regul 2001 Jun;35(2):95-100.
      pubmed: 11563938
    3. Arlt W, Stewart PM. Adrenal corticosteroid biosynthesis, metabolism, and action.. Endocrinol Metab Clin North Am 2005 Jun;34(2):293-313, viii.
      pubmed: 15850843doi: 10.1016/j.ecl.2005.01.002google scholar: lookup
    4. Kallen C, Arakane F, Sugawara T. Structure, function and regulated expression of the steroidogenic acute regulatory (StAR) protein.. In: Margioris A, Chrousos G, editors. Contemporary Endocrinology: Adrenal Disorders. Humana Press; Totowa, NJ: 2001. pp. 107–117.
    5. Stewart P. The Adrenal Cortex.. In: Kronenberg H, Melmed S, Polonsky K, Larsen P, editors. Williams Textbook of Endocrinology. 11 ed. Saunders Elsevier; Philadelphia: 2008. pp. 445–503.
    6. Rijnberk A, Mol J. Adrenocortical Function.. In: Kaneko J, Harvey J, Bruss M, editors. Clinical Biochemistry of Domestic Animals. 5th ed. Academic Press; San Diego: 1997. pp. 553–570.
    7. Maier C, Kotzmann H, Luger A. CRH-receptors and their ligands.. In: Gaillard R, editor. The ACTH Axis: Pathogenesis, Diagnosis, and Treatment. Kluwer Academic Publishers; Boston: 2003. pp. 65–83.
    8. Clark A, King P. The ACTH receptor and its mutations.. In: Gaillard R, editor. The ACTH Axis: Pathogenesis, Diagnosis, and Treatment. Kluwer Academic Publishers; Boston: 2003. pp. 171–190.
    9. Lewis JG, Bagley CJ, Elder PA, Bachmann AW, Torpy DJ. Plasma free cortisol fraction reflects levels of functioning corticosteroid-binding globulin.. Clin Chim Acta 2005 Sep;359(1-2):189-94.
      pubmed: 15904907doi: 10.1016/j.cccn.2005.03.044google scholar: lookup
    10. Adcock R, Kattesh H, Robert M, Saxton A, Carroll J. Relationships between plasma cortisol, cortisosteroid-binding globulin (CBG) and the free cortisol index (FCI) in pigs over a 24 hours period.. J An Vet Adv 2006;5:85–91.
    11. Irvine CH, Alexander SL. Measurement of free cortisol and the capacity and association constant of cortisol-binding proteins in plasma of foals and adult horses.. J Reprod Fertil Suppl 1987;35:19-24.
      pubmed: 3479574
    12. Meyer HP, Rothuizen J. Determination of the percentage of free cortisol in plasma in the dog by ultrafiltration/dialysis.. Domest Anim Endocrinol 1993 Jan;10(1):45-53.
      pubmed: 8467645doi: 10.1016/0739-7240(93)90007-xgoogle scholar: lookup
    13. Nicolaides NC, Galata Z, Kino T, Chrousos GP, Charmandari E. The human glucocorticoid receptor: molecular basis of biologic function.. Steroids 2010 Jan;75(1):1-12.
      pmc: PMC2813911pubmed: 19818358doi: 10.1016/j.steroids.2009.09.002google scholar: lookup
    14. Marik PE, Zaloga GP. Adrenal insufficiency in the critically ill: a new look at an old problem.. Chest 2002 Nov;122(5):1784-96.
      pubmed: 12426284doi: 10.1378/chest.122.5.1784google scholar: lookup
    15. Young W. Endocrine Hypertension.. In: Kronenberg H, Melmed S, Polonsky K, Larsen P, editors. Williams Textbook of Endocrinology. 11th ed. Saunders; Elsevier, Inc.; Philadelphia: 2008. pp. 505–537.
    16. Hedberg Y, Dalin AM, Forsberg M, Lundeheim N, Hoffmann B, Ludwig C, Kindahl H. Effect of ACTH (tetracosactide) on steroid hormone levels in the mare. Part A: effect in intact normal mares and mares with possible estrous related behavioral abnormalities.. Anim Reprod Sci 2007 Jul;100(1-2):73-91.
      pubmed: 16870362doi: 10.1016/j.anireprosci.2006.06.008google scholar: lookup
    17. Federman D. The Endocrine Patient.. In: Kronenberg H, Melmed S, Polonsky K, Larsen P, editors. Williams Textbook of Endocrinology. 11th ed. Saunders Elsevier; Philadelphia: 2008. pp. 12–17.
    18. Gehlen H, Sundermann T, Rohn K, Stadler P. Aldosterone plasma concentration in horses with heart valve insufficiencies.. Res Vet Sci 2008 Oct;85(2):340-4.
      pubmed: 18086482doi: 10.1016/j.rvsc.2007.11.002google scholar: lookup
    19. Haffner JC, Fecteau KA, Eiler H, Tserendorj T, Hoffman RM, Oliver JW. Blood steroid concentrations in domestic Mongolian horses.. J Vet Diagn Invest 2010 Jul;22(4):537-43.
      pubmed: 20622223doi: 10.1177/104063871002200407google scholar: lookup
    20. Hollis AR, Boston RC, Corley KT. Plasma aldosterone, vasopressin and atrial natriuretic peptide in hypovolaemia: a preliminary comparative study of neonatal and mature horses.. Equine Vet J 2008 Jan;40(1):64-9.
      pubmed: 18083662doi: 10.2746/042516407x235795google scholar: lookup
    21. Bornstein SR, Engeland WC, Ehrhart-Bornstein M, Herman JP. Dissociation of ACTH and glucocorticoids.. Trends Endocrinol Metab 2008 Jul;19(5):175-80.
      pubmed: 18394919doi: 10.1016/j.tem.2008.01.009google scholar: lookup
    22. Annane D, Maxime V, Ibrahim F, Alvarez JC, Abe E, Boudou P. Diagnosis of adrenal insufficiency in severe sepsis and septic shock.. Am J Respir Crit Care Med 2006 Dec 15;174(12):1319-26.
      pubmed: 16973979doi: 10.1164/rccm.200509-1369ocgoogle scholar: lookup
    23. Marik PE. Critical illness-related corticosteroid insufficiency.. Chest 2009 Jan;135(1):181-193.
      pubmed: 19136406doi: 10.1378/chest.08-1149google scholar: lookup
    24. Marik PE, Pastores SM, Annane D, Meduri GU, Sprung CL, Arlt W, Keh D, Briegel J, Beishuizen A, Dimopoulou I, Tsagarakis S, Singer M, Chrousos GP, Zaloga G, Bokhari F, Vogeser M. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine.. Crit Care Med 2008 Jun;36(6):1937-49.
      pubmed: 18496365doi: 10.1097/ccm.0b013e31817603bagoogle scholar: lookup
    25. Marik PE, Zaloga GP. Adrenal insufficiency during septic shock.. Crit Care Med 2003 Jan;31(1):141-5.
      pubmed: 12545007doi: 10.1097/00003246-200301000-00022google scholar: lookup
    26. Kozyra EF, Wax RS, Burry LD. Can 1 microg of cosyntropin be used to evaluate adrenal insufficiency in critically ill patients?. Ann Pharmacother 2005 Apr;39(4):691-8.
      pubmed: 15741424doi: 10.1345/aph.1e139google scholar: lookup
    27. Siraux V, De Backer D, Yalavatti G, Mélot C, Gervy C, Mockel J, Vincent JL. Relative adrenal insufficiency in patients with septic shock: comparison of low-dose and conventional corticotropin tests.. Crit Care Med 2005 Nov;33(11):2479-86.
      pubmed: 16276169doi: 10.1097/01.ccm.0000185641.87051.7cgoogle scholar: lookup
    28. Reijerkerk EP, Visser EK, van Reenen CG, van der Kolk JH. Effects of various doses of ovine corticotrophin-releasing hormone on plasma and saliva cortisol concentrations in horses.. Am J Vet Res 2009 Mar;70(3):361-4.
      pubmed: 19254148doi: 10.2460/ajvr.70.3.361google scholar: lookup
    29. Schmidt IL, Lahner H, Mann K, Petersenn S. Diagnosis of adrenal insufficiency: Evaluation of the corticotropin-releasing hormone test and Basal serum cortisol in comparison to the insulin tolerance test in patients with hypothalamic-pituitary-adrenal disease.. J Clin Endocrinol Metab 2003 Sep;88(9):4193-8.
      pubmed: 12970286doi: 10.1210/jc.2002-021897google scholar: lookup
    30. Fiad TM, Kirby JM, Cunningham SK, McKenna TJ. The overnight single-dose metyrapone test is a simple and reliable index of the hypothalamic-pituitary-adrenal axis.. Clin Endocrinol (Oxf) 1994 May;40(5):603-9.
      pubmed: 8013141doi: 10.1111/j.1365-2265.1994.tb03011.xgoogle scholar: lookup
    31. Luna SP, Taylor PM, Wheeler MJ. Cardiorespiratory, endocrine and metabolic changes in ponies undergoing intravenous or inhalation anaesthesia.. J Vet Pharmacol Ther 1996 Aug;19(4):251-8.
      pubmed: 8866452doi: 10.1111/j.1365-2885.1996.tb00046.xgoogle scholar: lookup
    32. Alexander SL, Irvine CH, Donald RA. Dynamics of the regulation of the hypothalamo-pituitary-adrenal (HPA) axis determined using a nonsurgical method for collecting pituitary venous blood from horses.. Front Neuroendocrinol 1996 Jan;17(1):1-50.
      pubmed: 8788568doi: 10.1006/frne.1996.0001google scholar: lookup
    33. Giordano R, Picu A, Bonelli L, Balbo M, Berardelli R, Marinazzo E, Corneli G, Ghigo E, Arvat E. Hypothalamus-pituitary-adrenal axis evaluation in patients with hypothalamo-pituitary disorders: comparison of different provocative tests.. Clin Endocrinol (Oxf) 2008 Jun;68(6):935-41.
      pubmed: 18031311doi: 10.1111/j.1365-2265.2007.03141.xgoogle scholar: lookup
    34. Silver M, Fowden AL, Knox J, Ousey JC, Franco R, Rossdale PD. Sympathoadrenal and other responses to hypoglycaemia in the young foal.. J Reprod Fertil Suppl 1987;35:607-14.
      pubmed: 3479615
    35. Alexander SL, Roud HK, Irvine CH. Effect of insulin-induced hypoglycaemia on secretion patterns and rates of corticotrophin-releasing hormone, arginine vasopressin and adrenocorticotrophin in horses.. J Endocrinol 1997 Jun;153(3):401-9.
      pubmed: 9203994doi: 10.1677/joe.0.1530401google scholar: lookup
    36. Van den Berghe G. Endocrinology of Critical Illness.. Critical Care Clinics Saunders; Philadelphia: 2006; No. 22, no. 1.
    37. Cohen J, Venkatesh B. Assessment of tissue cortisol activity.. Crit Care Resusc 2009 Dec;11(4):287-9.
      pubmed: 20001880
    38. Liu DH, Su YP, Zhang W, Lu SF, Ran XZ, Gao JS, Cheng TM. Changes in glucocorticoid and mineralocorticoid receptors of liver and kidney cytosols after pathologic stress and its regulation in rats.. Crit Care Med 2002 Mar;30(3):623-7.
      pubmed: 11990926doi: 10.1097/00003246-200203000-00022google scholar: lookup
    39. Marik PE. Mechanisms and clinical consequences of critical illness associated adrenal insufficiency.. Curr Opin Crit Care 2007 Aug;13(4):363-9.
      pubmed: 17599004doi: 10.1097/mcc.0b013e32818a6d74google scholar: lookup
    40. Meduri GU, Muthiah MP, Carratu P, Eltorky M, Chrousos GP. Nuclear factor-kappaB- and glucocorticoid receptor alpha- mediated mechanisms in the regulation of systemic and pulmonary inflammation during sepsis and acute respiratory distress syndrome. Evidence for inflammation-induced target tissue resistance to glucocorticoids.. Neuroimmunomodulation 2005;12(6):321-38.
      pubmed: 16557033doi: 10.1159/000091126google scholar: lookup
    41. Fazio E, Medica P, Aronica V, Grasso L, Ferlazzo A. Circulating beta-endorphin, adrenocorticotrophic hormone and cortisol levels of stallions before and after short road transport: stress effect of different distances.. Acta Vet Scand 2008 Mar 3;50(1):6.
      pmc: PMC2268694pubmed: 18315878doi: 10.1186/1751-0147-50-6google scholar: lookup
    42. Place NJ, McGowan CM, Lamb SV, Schanbacher BJ, McGowan T, Walsh DM. Seasonal variation in serum concentrations of selected metabolic hormones in horses.. J Vet Intern Med 2010 May-Jun;24(3):650-4.
      pubmed: 20384949doi: 10.1111/j.1939-1676.2010.0500.xgoogle scholar: lookup
    43. Kudielka BM, Buske-Kirschbaum A, Hellhammer DH, Kirschbaum C. HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults, and children: impact of age and gender.. Psychoneuroendocrinology 2004 Jan;29(1):83-98.
      pubmed: 14575731doi: 10.1016/s0306-4530(02)00146-4google scholar: lookup
    44. Lefcourt AM, Bitman J, Kahl S, Wood DL. Circadian and ultradian rhythms of peripheral cortisol concentrations in lactating dairy cows.. J Dairy Sci 1993 Sep;76(9):2607-12.
      pubmed: 8227661doi: 10.3168/jds.s0022-0302(93)77595-5google scholar: lookup
    45. Martin LG, Behrend EN, Mealey KL, Carpenter DM, Hickey KC. Effect of low doses of cosyntropin on serum cortisol concentrations in clinically normal dogs.. Am J Vet Res 2007 May;68(5):555-60.
      pubmed: 17472457doi: 10.2460/ajvr.68.5.555google scholar: lookup
    46. Bousquet-Mélou A, Formentini E, Picard-Hagen N, Delage L, Laroute V, Toutain PL. The adrenocorticotropin stimulation test: contribution of a physiologically based model developed in horse for its interpretation in different pathophysiological situations encountered in man.. Endocrinology 2006 Sep;147(9):4281-91.
      pubmed: 16763068doi: 10.1210/en.2005-1161google scholar: lookup
    47. McKeever KH, Malinowski K. Endocrine response to exercise in young and old horses.. Equine Vet J Suppl 1999 Jul;(30):561-6.
      pubmed: 10659318doi: 10.1111/j.2042-3306.1999.tb05284.xgoogle scholar: lookup
    48. Silver M, Ousey JC, Dudan FE, Fowden AL, Knox J, Cash RS, Rossdale PD. Studies on equine prematurity 2: Post natal adrenocortical activity in relation to plasma adrenocorticotrophic hormone and catecholamine levels in term and premature foals.. Equine Vet J 1984 Jul;16(4):278-86.
      pubmed: 6090119doi: 10.1111/j.2042-3306.1984.tb01927.xgoogle scholar: lookup
    49. Silver M, Fowden AL. Prepartum adrenocortical maturation in the fetal foal: responses to ACTH.. J Endocrinol 1994 Sep;142(3):417-25.
      pubmed: 7964292doi: 10.1677/joe.0.1420417google scholar: lookup
    50. Ousey JC, Rossdale PD, Fowden AL, Palmer L, Turnbull C, Allen WR. Effects of manipulating intrauterine growth on post natal adrenocortical development and other parameters of maturity in neonatal foals.. Equine Vet J 2004 Nov;36(7):616-21.
      pubmed: 15581327doi: 10.2746/0425164044864598google scholar: lookup
    51. Rossdale PD, Ousey JC, Silver M, Fowden A. Studies on equine prematurity 6: Guidelines for assessment of foal maturity.. Equine Vet J 1984 Jul;16(4):300-2.
      pubmed: 6090120doi: 10.1111/j.2042-3306.1984.tb01931.xgoogle scholar: lookup
    52. Han X, Fowden AL, Silver M, Holdstock N, McGladdery AJ, Ousey JC, Allen WR, Rossdale PD, Challis JR. Immunohistochemical localisation of steroidogenic enzymes and phenylethanolamine-N-methyl-transferase (PNMT) in the adrenal gland of the fetal and newborn foal.. Equine Vet J 1995 Mar;27(2):140-6.
      pubmed: 7607148doi: 10.1111/j.2042-3306.1995.tb03051.xgoogle scholar: lookup
    53. Weng Q, Tanaka Y, Taniyama H, Tsunoda N, Nambo Y, Watanabe G, Taya K. Immunolocalization of steroidogenic enzymes in equine fetal adrenal glands during mid-late gestation.. J Reprod Dev 2007 Oct;53(5):1093-8.
      pubmed: 17585182doi: 10.1262/jrd.18159google scholar: lookup
    54. Riley SC, Boshier DP, Luu-The V, Labrie F, Challis JR. Immunohistochemical localization of 3 beta-hydroxysteroid/delta 5-delta 4-isomerase, tyrosine hydroxylase and phenylethanolamine N-methyl transferase in adrenal glands of sheep fetuses throughout gestation and in neonates.. J Reprod Fertil 1992 Sep;96(1):127-34.
      pubmed: 1359136doi: 10.1530/jrf.0.0960127google scholar: lookup
    55. Donaldson MT, McDonnell SM, Schanbacher BJ, Lamb SV, McFarlane D, Beech J. Variation in plasma adrenocorticotropic hormone concentration and dexamethasone suppression test results with season, age, and sex in healthy ponies and horses.. J Vet Intern Med 2005 Mar-Apr;19(2):217-22.
      pubmed: 15822567doi: 10.1892/0891-6640(2005)19<217:vipahc>2.0.co;2google scholar: lookup
    56. Hart KA, Heusner GL, Norton NA, Barton MH. Hypothalamic-pituitary-adrenal axis assessment in healthy term neonatal foals utilizing a paired low dose/high dose ACTH stimulation test.. J Vet Intern Med 2009 Mar-Apr;23(2):344-51.
      pubmed: 19192152doi: 10.1111/j.1939-1676.2008.00271.xgoogle scholar: lookup
    57. Irvine CH, Alexander SL. Factors affecting the circadian rhythm in plasma cortisol concentrations in the horse.. Domest Anim Endocrinol 1994 Apr;11(2):227-38.
      pubmed: 8045104doi: 10.1016/0739-7240(94)90030-2google scholar: lookup
    58. Wong DM, Vo DT, Alcott CJ, Stewart AJ, Peterson AD, Sponseller BA, Hsu WH. Adrenocorticotropic hormone stimulation tests in healthy foals from birth to 12 weeks of age.. Can J Vet Res 2009 Jan;73(1):65-72.
      pmc: PMC2613599pubmed: 19337398
    59. Hart KA, Barton MH, Ferguson DC, Berghaus R, Slovis NM, Heusner GL, Hurley DJ. Serum free cortisol fraction in healthy and septic neonatal foals.. J Vet Intern Med 2011 Mar-Apr;25(2):345-55.
      pubmed: 21281351doi: 10.1111/j.1939-1676.2010.0667.xgoogle scholar: lookup
    60. Hart KA, Dirikolu L, Ferguson DC, Norton NA, Barton MH. Daily endogenous cortisol production and hydrocortisone pharmacokinetics in adult horses and neonatal foals.. Am J Vet Res 2012 Jan;73(1):68-75.
      pubmed: 22204290doi: 10.2460/ajvr.73.1.68google scholar: lookup
    61. Broughton Pipkin F, Ousey JC, Wallace CP, Rossdale PD. Studies on equine prematurity 4: Effect of salt and water loss on the renin-angiotensin-aldosterone system in the newborn foal.. Equine Vet J 1984 Jul;16(4):292-7.
      pubmed: 6383811doi: 10.1111/j.2042-3306.1984.tb01929.xgoogle scholar: lookup
    62. Greco DS. Hypoadrenocorticism in small animals.. Clin Tech Small Anim Pract 2007 Feb;22(1):32-5.
      pubmed: 17542195doi: 10.1053/j.ctsap.2007.02.005google scholar: lookup
    63. de Herder WLS. Overview of Hyper- and Hypoadrencorticism.. In: Margioris A, Chrousos G, editors. Contemporary Endocrinology: Adrenal Disorders. Humana Press; Totowa, NJ: 2001. pp. 143–153.
    64. LEVIN J, CLUFF LE. ENDOTOXEMIA AND ADRENAL HEMORRHAGE. A MECHANISM FOR THE WATERHOUSE-FRIDERICHSEN SYNDROME.. J Exp Med 1965 Feb 1;121(2):247-60.
      pmc: PMC2137979pubmed: 14264270doi: 10.1084/jem.121.2.247google scholar: lookup
    65. Loisa P, Rinne T, Kaukinen S. Adrenocortical function and multiple organ failure in severe sepsis.. Acta Anaesthesiol Scand 2002 Feb;46(2):145-51.
      pubmed: 11942861doi: 10.1034/j.1399-6576.2002.460204.xgoogle scholar: lookup
    66. Dybdal N, McFarlane D. Endocrine and metabolic diseases.. In: Smith B, editor. Large Animal Internal Medicine. 4th ed. Mosby; Philadelphia, PA: 2009. p. 1345.
    67. Guillamondegui OD, Gunter OL, Patel S, Fleming S, Cotton BA, Morris JA Jr. Acute adrenal insufficiency may affect outcome in the trauma patient.. Am Surg 2009 Apr;75(4):287-90.
      pubmed: 19385286
    68. Henzen C, Kobza R, Schwaller-Protzmann B, Stulz P, Briner VA. Adrenal function during coronary artery bypass grafting.. Eur J Endocrinol 2003 Jun;148(6):663-8.
      pubmed: 12773139doi: 10.1530/eje.0.1480663google scholar: lookup
    69. Aneja R, Carcillo JA. What is the rationale for hydrocortisone treatment in children with infection-related adrenal insufficiency and septic shock?. Arch Dis Child 2007 Feb;92(2):165-9.
      pmc: PMC2083316pubmed: 17003064doi: 10.1136/adc.2005.088450google scholar: lookup
    70. Elsouri N, Bander J, Guzman JA. Relative adrenal insufficiency in patients with septic shock; a close look to practice patterns.. J Crit Care 2006 Mar;21(1):73-7.
      pubmed: 16616627doi: 10.1016/j.jcrc.2005.09.055google scholar: lookup
    71. Fernández J, Escorsell A, Zabalza M, Felipe V, Navasa M, Mas A, Lacy AM, Ginès P, Arroyo V. Adrenal insufficiency in patients with cirrhosis and septic shock: Effect of treatment with hydrocortisone on survival.. Hepatology 2006 Nov;44(5):1288-95.
      pubmed: 17058239doi: 10.1002/hep.21352google scholar: lookup
    72. Pizarro CF, Troster EJ, Damiani D, Carcillo JA. Absolute and relative adrenal insufficiency in children with septic shock.. Crit Care Med 2005 Apr;33(4):855-9.
      pubmed: 15818116doi: 10.1097/01.ccm.0000159854.23324.84google scholar: lookup
    73. McGavin M, Zachary J. Pathologic Basis of Veterinary Disease.. 4th ed. Mosby Elsevier; St. Louis: 2007.
    74. de Jong FH, Mallios C, Jansen C, Scheck PA, Lamberts SW. Etomidate suppresses adrenocortical function by inhibition of 11 beta-hydroxylation.. J Clin Endocrinol Metab 1984 Dec;59(6):1143-7.
      pubmed: 6092411doi: 10.1210/jcem-59-6-1143google scholar: lookup
    75. Beishuizen A, Thijs LG. Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis.. J Endotoxin Res 2003;9(1):3-24.
      pubmed: 12691614doi: 10.1179/096805103125001298google scholar: lookup
    76. Gaillard R. Interactions between the hypothalamic-pituitary-adrenal axis and the immunological system.. In: Gaillard R, editor. The ACTH Axis: Pathogenesis, Diagnosis, and Treatment. Kluwer Academic Publishers; Boston: 2003. pp. 109–135.
    77. Judd AM, Call GB, Barney M, McIlmoil CJ, Balls AG, Adams A, Oliveira GK. Possible function of IL-6 and TNF as intraadrenal factors in the regulation of adrenal steroid secretion.. Ann N Y Acad Sci 2000;917:628-37.
      pubmed: 11268391doi: 10.1111/j.1749-6632.2000.tb05428.xgoogle scholar: lookup
    78. Sharshar T, Gray F, Lorin de la Grandmaison G, Hopkinson NS, Ross E, Dorandeu A, Orlikowski D, Raphael JC, Gajdos P, Annane D. Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock.. Lancet 2003 Nov 29;362(9398):1799-805.
      pubmed: 14654318doi: 10.1016/s0140-6736(03)14899-4google scholar: lookup
    79. Aubry JM, Turnbull AV, Pozzoli G, Rivier C, Vale W. Endotoxin decreases corticotropin-releasing factor receptor 1 messenger ribonucleic acid levels in the rat pituitary.. Endocrinology 1997 Apr;138(4):1621-6.
      pubmed: 9075723doi: 10.1210/endo.138.4.5050google scholar: lookup
    80. Qahwash IM, Cassar CA, Radcliff RP, Smith GW. Bacterial lipopolysaccharide-induced coordinate downregulation of arginine vasopressin receptor V3 and corticotropin-releasing factor receptor 1 messenger ribonucleic acids in the anterior pituitary of endotoxemic steers.. Endocrine 2002 Jun;18(1):13-20.
      pubmed: 12166619doi: 10.1385/endo:18:1:13google scholar: lookup
    81. Liu LY, Sun B, Tian Y, Lu BZ, Wang J. Changes of pulmonary glucocorticoid receptor and phospholipase A2 in sheep with acute lung injury after high dose endotoxin infusion.. Am Rev Respir Dis 1993 Oct;148(4 Pt 1):878-81.
      pubmed: 8214942doi: 10.1164/ajrccm/148.4_pt_1.878google scholar: lookup
    82. Couëtil LL, Hoffman AM. Adrenal insufficiency in a neonatal foal.. J Am Vet Med Assoc 1998 May 15;212(10):1594-6.
      pubmed: 9604031
    83. Gold JR, Divers TJ, Barton MH, Lamb SV, Place NJ, Mohammed HO, Bain FT. Plasma adrenocorticotropin, cortisol, and adrenocorticotropin/cortisol ratios in septic and normal-term foals.. J Vet Intern Med 2007 Jul-Aug;21(4):791-6.
      pubmed: 17708401doi: 10.1892/0891-6640(2007)21[791:pacacr]2.0.co;2google scholar: lookup
    84. Hurcombe SD, Toribio RE, Slovis N, Kohn CW, Refsal K, Saville W, Mudge MC. Blood arginine vasopressin, adrenocorticotropin hormone, and cortisol concentrations at admission in septic and critically ill foals and their association with survival.. J Vet Intern Med 2008 May-Jun;22(3):639-47.
      pubmed: 18466247doi: 10.1111/j.1939-1676.2008.0090.xgoogle scholar: lookup
    85. Hart KA, Slovis NM, Barton MH. Hypothalamic-pituitary-adrenal axis dysfunction in hospitalized neonatal foals.. J Vet Intern Med 2009 Jul-Aug;23(4):901-12.
      pubmed: 19496914doi: 10.1111/j.1939-1676.2009.0323.xgoogle scholar: lookup
    86. Wong DM, Vo DT, Alcott CJ, Peterson AD, Sponseller BA, Hsu WH. Baseline plasma cortisol and ACTH concentrations and response to low-dose ACTH stimulation testing in ill foals.. J Am Vet Med Assoc 2009 Jan 1;234(1):126-32.
      pubmed: 19119977doi: 10.2460/javma.234.1.126google scholar: lookup
    87. Fernandez EF, Watterberg KL. Relative adrenal insufficiency in the preterm and term infant.. J Perinatol 2009 May;29 Suppl 2:S44-9.
      pubmed: 19399009doi: 10.1038/jp.2009.24google scholar: lookup
    88. Hart KA, Barton MH, Vandenplas ML, Hurley DJ. Effects of low-dose hydrocortisone therapy on immune function in neonatal horses.. Pediatr Res 2011 Jul;70(1):72-7.
      pmc: PMC3111865pubmed: 21430601doi: 10.1203/pdr.0b013e31821b502bgoogle scholar: lookup
    89. Dowling PM, Williams MA, Clark TP. Adrenal insufficiency associated with long-term anabolic steroid administration in a horse.. J Am Vet Med Assoc 1993 Oct 15;203(8):1166-9.
      pubmed: 8244866
    90. Baker HW, Baker ID, Epstein VM, Hudson B. Effect of stress on steroid hormone levels in racehorses.. Aust Vet J 1982 Feb;58(2):70-1.
      pubmed: 7082242doi: 10.1111/j.1751-0813.1982.tb02692.xgoogle scholar: lookup
    91. Unwin RJ, Capasso G. The renal tubular acidoses.. J R Soc Med 2001 May;94(5):221-5.
      pmc: PMC1281453pubmed: 11385088doi: 10.1177/014107680109400506google scholar: lookup
    92. Arroyo LG, Stämpfli HR. Equine renal tubular disorders.. Vet Clin North Am Equine Pract 2007 Dec;23(3):631-9, vi.
      pubmed: 18061854doi: 10.1016/j.cveq.2007.09.005google scholar: lookup
    93. Styne D, Grumbach M. Puberty: Ontogeny, Neuroendocrinology, Physiology, and Disorders.. In: Kronenberg H, Melmed S, Polonsky K, Larsen P, editors. Williams Textbook of Endocrinology. 11th ed. Saunders: Elsevier, Inc.; Philadelphia: 2008. pp. 969–1166.

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