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Home / Equine Research Bank / Animals (Basel) / Age-Dependent Intestinal Repair: Implications for Foals with...
Animals : an open access journal from MDPI2021; 11(12); doi: 10.3390/ani11123337

Age-Dependent Intestinal Repair: Implications for Foals with Severe Colic.

Abstract: Colic is a leading cause of death in horses, with the most fatal form being strangulating obstruction which directly damages the intestinal barrier. Following surgical intervention, it is imperative that the intestinal barrier rapidly repairs to prevent translocation of gut bacteria and their products and ensure survival of the patient. Age-related disparities in survival have been noted in many species, including horses, humans, and pigs, with younger patients suffering poorer clinical outcomes. Maintenance and repair of the intestinal barrier is regulated by a complex mucosal microenvironment, of which the ENS, and particularly a developing network of subepithelial enteric glial cells, may be of particular importance in neonates with colic. Postnatal development of an immature enteric glial cell network is thought to be driven by the microbial colonization of the gut and therefore modulated by diet-influenced changes in bacterial populations early in life. Here, we review the current understanding of the roles of the gut microbiome, nutrition, stress, and the ENS in maturation of intestinal repair mechanisms after foaling and how this may influence age-dependent outcomes in equine colic cases.
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Publication Date: 2021-11-23 PubMed ID: 34944114PubMed Central: PMC8697879DOI: 10.3390/ani11123337Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article explores the age-related differences in the ability of the intestinal barrier in horses to repair, particularly after surgical intervention following severe colic. It emphasizes the roles of the gut microbiome, nutrition, stress, and the enteric nervous system in this process.

Introduction to the Problem

  • The article departs from the observation that colic is a major cause of death in horses, particularly the form known as strangulating obstruction that severely damages the intestinal barrier.
  • This issue necessitates surgical interventions, after which quick repair of the intestinal barrier is crucial to avoid translocation of gut bacteria and to ensure the patients’ survival.
  • Significantly, the authors note that survival rates vary by age across different species, including horses, humans, and pigs. Younger patients seem to have a worse clinical prognosis.

Role of Enteric Glial Cells and the ENS

  • The research emphasizes the role of the enteric nervous system (ENS) and enteric glial cells in maintaining and healing the intestinal barrier.
  • In particular, the development of the enteric glial cell network in neonates undergoing colic may be key to understanding their condition.
  • The article suggests that the postnatal maturation of these cells is largely driven by the microbial colonization of the gut, which can be modulated by diet-influenced changes in gut bacteria early in life.

The Gut Microbiome, Nutrition, Stress and Colic

  • The authors review current understanding of how the gut microbiome, nutrition, and stress impact the maturation of intestinal repair mechanisms, especially after birth (foaling).
  • They highlight that these factors might play a significant role in explaining age-dependent outcomes in horses suffering from colic.
  • Although the article does not detail specific nutritional or stress-related interventions, the understanding gained from this review might pave the way for more effective treatment strategies for equine colic in the future.

Cite This Article

APA
Erwin SJ, Blikslager AT, Ziegler AL. (2021). Age-Dependent Intestinal Repair: Implications for Foals with Severe Colic. Animals (Basel), 11(12). https://doi.org/10.3390/ani11123337

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 11
Issue: 12

Researcher Affiliations

Erwin, Sara J
  • College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
Blikslager, Anthony T
  • College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
Ziegler, Amanda L
  • College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.

Grant Funding

  • R01 HD095876 / NIH HHS
  • P30 DK034987 / NIDDK NIH HHS
  • P30 DK034987 / NIH HHS
  • L40 OD028437 / NIH HHS
  • K01 OD028207 / NIH HHS
  • AFRI-006609 / United States Department of Agriculture
  • R01 HD095876 / NICHD NIH HHS

Conflict of Interest Statement

The authors declare no conflict of interest.

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Citations

This article has been cited 1 times.
  1. Gomez DE, Wong D, MacNicol J, Dembek K. The fecal bacterial microbiota of healthy and sick newborn foals. J Vet Intern Med 2023 Jan;37(1):315-322.
    doi: 10.1111/jvim.16596pubmed: 36519210google scholar: lookup
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