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The journals of gerontology. Series A, Biological sciences and medical sciences2016; 72(4); 455-463; doi: 10.1093/gerona/glw136

Age-Related Changes in Locomotor Performance Reveal a Similar Pattern for Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo sapiens.

Abstract: Locomotion is one of the major physiological functions for most animals. Previous studies have described aging mechanisms linked to locomotor performance among different species. However, the precise dynamics of these age-related changes, and their interactions with development and senescence, are largely unknown. Here, we use the same conceptual framework to describe locomotor performances in Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo sapiens. We show that locomotion is a consistent biomarker of age-related changes, with an asymmetrical pattern throughout life, regardless of the type of effort or its duration. However, there is variation (i) among species for the same mode of locomotion, (ii) within species for different modes of locomotion, and (iii) among individuals of the same species for the same mode of locomotion. Age-related patterns are modulated by genetic (such as selective breeding) as well as environmental conditions (such as temperature). However, in all cases, the intersection of the rising developmental phase and the declining senescent phase reveals neither a sharp transition nor a plateau, but a smooth transition, emphasizing a crucial moment: the age at peak performance. This transition may define a specific target for future investigations on the dynamics of such biological interactions.
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Publication Date: 2016-08-16 PubMed ID: 27522057PubMed Central: PMC5861937DOI: 10.1093/gerona/glw136Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article looks into the changes in locomotor performance in various species like Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo sapiens as they age. It concludes that locomotion is a reliable biomarker of age-related changes across these species, but variations exist among and within species, often influenced by genetic and environmental factors.

Examining Age-Related Changes in Locomotor Performance

  • The research focuses on how locomotor performance (the ability to move from one place to another) changes with aging in various species: Caenorhabditis elegans (a nematode worm), Mus domesticus (the house mouse), Canis familiaris (domestic dogs), Equus caballus (horses), and Homo sapiens (humans).
  • The research sought to broaden the understanding of how these changes occur and interact with growth and senescence (the aging process).

Locomotion as a Biomarker of Age-Related Changes

  • The researchers found that locomotion presents a consistent biomarker of age-related changes. It displays an asymmetrical pattern throughout the lifespan, regardless of the type of locomotor effort or its duration.
  • As a biomarker, locomotor performance can be a helpful tool in determining creatures’ biological age and predicting potential age-related complications, such as decreased mobility and associated health risks.

Variations in Locomotor Performance

  • While locomotion serves as a reliable measure, substantial differences were found both among different species and within a single species for different types of movement.
  • Individual variations were also observed within the same species for the same mode of locomotion.
  • These differences can be attributed to specific genetic factors, like selective breeding, and different environmental conditions, such as temperature.

Studying the Intersection of Development and Senescence

  • The research determined that the intersection between the rising phase of development (growth and improvement of locomotor abilities) and the declining senescent phase (locomotor performance deterioration due to aging) does not show a sharp transition or a plateau.
  • Instead, a smooth transition was observed, highlighting a moment of ‘peak performance’ age, wherein the individual performs at their optimum before the decline starts.
  • This transition could serve as a specific target for future investigations on the dynamics of biological interactions concerning age and locomotion.

Cite This Article

APA
Marck A, Berthelot G, Foulonneau V, Marc A, Antero-Jacquemin J, Noirez P, Bronikowski AM, Morgan TJ, Garland T, Carter PA, Hersen P, Di Meglio JM, Toussaint JF. (2016). Age-Related Changes in Locomotor Performance Reveal a Similar Pattern for Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo sapiens. J Gerontol A Biol Sci Med Sci, 72(4), 455-463. https://doi.org/10.1093/gerona/glw136

Publication

The journals of gerontology. Series A, Biological sciences and medical sciences
ISSN: 1758-535X
NlmUniqueID: 9502837
Country: United States
Language: English
Volume: 72
Issue: 4
Pages: 455-463

Researcher Affiliations

Marck, Adrien
  • Institut de Recherche bio-Médicale et d'Epidémiologie du Sport (IRMES), EA 7329, Institut National du Sport, de l'Expertise et de la Performance (INSEP) and Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
  • Laboratoire Matière et Systèmes Complexes, UMR 7057, Université Paris Diderot and CNRS, Sorbonne Paris Cité, Paris, France.
Berthelot, Geoffroy
  • Institut de Recherche bio-Médicale et d'Epidémiologie du Sport (IRMES), EA 7329, Institut National du Sport, de l'Expertise et de la Performance (INSEP) and Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Foulonneau, Vincent
  • Institut de Recherche bio-Médicale et d'Epidémiologie du Sport (IRMES), EA 7329, Institut National du Sport, de l'Expertise et de la Performance (INSEP) and Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Marc, Andy
  • Institut de Recherche bio-Médicale et d'Epidémiologie du Sport (IRMES), EA 7329, Institut National du Sport, de l'Expertise et de la Performance (INSEP) and Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Antero-Jacquemin, Juliana
  • Institut de Recherche bio-Médicale et d'Epidémiologie du Sport (IRMES), EA 7329, Institut National du Sport, de l'Expertise et de la Performance (INSEP) and Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Noirez, Philippe
  • Institut de Recherche bio-Médicale et d'Epidémiologie du Sport (IRMES), EA 7329, Institut National du Sport, de l'Expertise et de la Performance (INSEP) and Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Bronikowski, Anne M
  • Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames.
Morgan, Theodore J
  • Division of Biology, Kansas State University, Manhattan.
Garland, Theodore
  • Department of Biology, University of California, Riverside.
Carter, Patrick A
  • School of Biological Sciences, Washington State University, Pullman.
Hersen, Pascal
  • Laboratoire Matière et Systèmes Complexes, UMR 7057, Université Paris Diderot and CNRS, Sorbonne Paris Cité, Paris, France.
Di Meglio, Jean-Marc
  • Laboratoire Matière et Systèmes Complexes, UMR 7057, Université Paris Diderot and CNRS, Sorbonne Paris Cité, Paris, France.
Toussaint, Jean-François
  • Institut de Recherche bio-Médicale et d'Epidémiologie du Sport (IRMES), EA 7329, Institut National du Sport, de l'Expertise et de la Performance (INSEP) and Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
  • Centre d'Investigations en Médecine du Sport, Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris, France.

MeSH Terms

  • Age Factors
  • Aging / physiology
  • Animals
  • Caenorhabditis elegans / physiology
  • Dogs / physiology
  • Horses / physiology
  • Humans
  • Locomotion / physiology
  • Mice / physiology
  • Time Factors

Grant Funding

  • P40 OD010440 / NIH HHS

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