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Home / Equine Research Bank / Open Vet J / Aging effect on plasma metabolites and hormones concentratio...
Open veterinary journal2015; 5(2); 154-157;

Aging effect on plasma metabolites and hormones concentrations in riding horses.

Abstract: Age effects on plasma metabolites, hormone concentrations, and enzyme activities related to energy metabolism were investigated in 20 riding horses. Animals were divided into two groups: Young (3-8 years) and aged (11-18 years). They were clinically healthy, and not obese. Plasma adiponectin (ADN) concentrations in aged horses were significantly lower than those in young horses (mean±SE, 6.5±1.3 µg mL(-1) vs, 10.9±1.7 µg mL(-1), Mann-Whitney U test, respectively; P=0.0233). Plasma non-esterified fatty acid levels and Insulin and malondialdehyde concentrations in aged group tended to increase compared to those in young group although there were not significant differences statistically. In aged group, malate dehydrogenase/lactate dehydrogenase (M/L) ratio, which is considered an energy metabolic indicator, did not change significantly compared to that in young group. Present data suggest that aging may negatively affect nutrition metabolism, but not induce remarkable changes in M/L ratio in riding horses.
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Publication Date: 2015-11-02 PubMed ID: 26623382PubMed Central: PMC4663796
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research discusses the effect of aging on the levels of plasma metabolites, hormones, and certain enzyme activities tied to energy metabolism in riding horses. It suggests that aging in horses may have a negative effect on nutritional metabolism but without significant changes to the energy metabolic indicator (M/L ratio).

Research Methodology

  • The study was conducted on 20 riding horses which were split into two groups. The groups were based on age, with one representing young horses aged 3-8 years and the other aged horses aged 11-18 years.
  • The horses were all clinically healthy and not obese, ensuring the results are not confounded by these factors.

Findings

  • The study found that in aged horses, plasma adiponectin (ADN) concentrations were significantly lower than those in young horses. This was statistically significant with a Mann-Whitney U test (P=0.0233) utilized for the comparison.
  • The study also noticed that plasma non-esterified fatty acid levels, along with Insulin and malondialdehyde concentrations, showed an upward trend in the aged group compared to the young ones. However, the differences noted here were not statistically significant.
  • The researchers found no significant change in malate dehydrogenase/lactate dehydrogenase (M/L) ratio, an energy metabolic indicator, in the aged group as compared to the young group.

Conclusion

  • The findings suggest that, although aging in horses might negatively affect nutrition metabolism, it does not induce substantial changes in their M/L ratio, an energy metabolic indicator.
  • This research provides valuable insights into how aging can affect metabolic processes in horses, with potential implications for how veterinarians and horse owners manage the health and diet of aging horses.

Cite This Article

APA
Kawasumi K, Yamamoto M, Koide M, Okada Y, Mori N, Yamamoto I, Arai T. (2015). Aging effect on plasma metabolites and hormones concentrations in riding horses. Open Vet J, 5(2), 154-157.

Publication

Open veterinary journal
ISSN: 2226-4485
NlmUniqueID: 101653182
Country: Libya
Language: English
Volume: 5
Issue: 2
Pages: 154-157

Researcher Affiliations

Kawasumi, K
  • Department of Basic Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
Yamamoto, M
  • Department of Basic Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
Koide, M
  • Japan Horseback Riding Club, 685-1 Kitanagai Miyoshicho, Iruma-gun, Saitama 354-0044, Japan.
Okada, Y
  • Department of Basic Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
Mori, N
  • Department of Basic Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
Yamamoto, I
  • Department of Basic Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
Arai, T
  • Department of Basic Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.

References

This article includes 20 references
  1. Balsan GA, Vieira JL, Oliveira AM, Portal VL. Relationship between adiponectin, obesity and insulin resistance.. Rev Assoc Med Bras (1992) 2015 Jan-Feb;61(1):72-80.
    pubmed: 25909213doi: 10.1590/1806-9282.61.01.072google scholar: lookup
  2. Bergmeyer HU, Bernt E. Malate dehydrogenase. UV-assay.. In: Bergmeyer HU, editor. Methods of Enzymatic Analysis. Vol. 2. New York: Academic Press; 1974. pp. 613–617..
  3. Carroll CL, Huntington PJ. Body condition scoring and weight estimation of horses.. Equine Vet J 1988 Jan;20(1):41-5.
    pubmed: 3366105doi: 10.1111/j.2042-3306.1988.tb01451.xgoogle scholar: lookup
  4. de Heredia FP, Gómez-Martínez S, Marcos A. Obesity, inflammation and the immune system.. Proc Nutr Soc 2012 May;71(2):332-8.
    pubmed: 22429824doi: 10.1017/s0029665112000092google scholar: lookup
  5. German AJ, Ryan VH, German AC, Wood IS, Trayhurn P. Obesity, its associated disorders and the role of inflammatory adipokines in companion animals.. Vet J 2010 Jul;185(1):4-9.
    pubmed: 20472476doi: 10.1016/j.tvjl.2010.04.004google scholar: lookup
  6. Hirakawa Y, Kawasumi K, Lee P, Mori N, Yamamoto I, Terasawa F, Arai T. Determination of oxidative energy metabolism and plasma LDH isoenzyme patterns of dolphins.. Open Vet. Sci. J. 2012;6:30–36.
  7. Hoenig M, Jordan ET, Glushka J, Kley S, Patil A, Waldron M, Prestegard JH, Ferguson DC, Wu S, Olson DE. Effect of macronutrients, age, and obesity on 6- and 24-h postprandial glucose metabolism in cats.. Am J Physiol Regul Integr Comp Physiol 2011 Dec;301(6):R1798-807.
    pmc: PMC4073915pubmed: 21940405doi: 10.1152/ajpregu.00342.2011google scholar: lookup
  8. Kaloustian HD, Stolzenbach FE, Everse J, Kaplan NO. Lactate dehydrogenase of lobster (Homarus americanus) tail muscle. I. Physical and chemical properties.. J Biol Chem 1969 Jun 10;244(11):2891-901.
    pubmed: 4306287
  9. Kawasumi K, Kashiwado N, Okada Y, Sawamura M, Sasaki Y, Iwazaki E, Mori N, Yamamoto I, Arai T. Age effects on plasma cholesterol and triglyceride profiles and metabolite concentrations in dogs.. BMC Vet Res 2014 Mar 5;10:57.
    pmc: PMC3946593pubmed: 24597741doi: 10.1186/1746-6148-10-57google scholar: lookup
  10. Li G, Lee P, Mori N, Yamamoto I, Arai T. Long term intensive exercise training leads to a higher plasma malate/lactate dehydrogenase (M/L) ratio and increased level of lipid mobilization in horses.. Vet Res Commun 2012 Jun;36(2):149-55.
    pubmed: 22297553doi: 10.1007/s11259-012-9515-0google scholar: lookup
  11. Martin LJ, Lutz TA, Daumas C, Bleis P, Nguyen P, Biourge V, Dumon HJ. Acute hormonal response to glucose, lipids and arginine infusion in overweight cats.. J Nutr Sci 2014;3:e8.
    pmc: PMC4153071pubmed: 25191616doi: 10.1017/jns.2014.4google scholar: lookup
  12. Mori N, Kawasumi K, Arai T. Comparison of the plasma insulin and adiponectin concentrations as metabolic markers in clinically healthy dog with aging.. J. Anim. Vet. Adv. 2012;11:971–974.
  13. Nakatsuji H, Kishida K, Sekimoto R, Komura N, Kihara S, Funahashi T, Shimomura I. Accumulation of adiponectin in inflamed adipose tissues of obese mice.. Metabolism 2014 Apr;63(4):542-53.
    pubmed: 24467915doi: 10.1016/j.metabol.2013.12.012google scholar: lookup
  14. Okada Y, Kawasumi K, Mori N, Yamamoto I, Arai T. Changes in Malate Dehydrogenase, Lactate Dehydrogenase and M/L Ratio as Energy Metabolism Markers of Acute Weight Gain.. Asian J. Anim. Vet. Adv. 2015;10(3):132–140.
  15. Park HJ, Lee SE, Oh JH, Seo KW, Song KH. Leptin, adiponectin and serotonin levels in lean and obese dogs.. BMC Vet Res 2014 May 13;10:113.
    pmc: PMC4030042pubmed: 24886049doi: 10.1186/1746-6148-10-113google scholar: lookup
  16. Park HJ, Lee SE, Kim HB, Isaacson RE, Seo KW, Song KH. Association of obesity with serum leptin, adiponectin, and serotonin and gut microflora in beagle dogs.. J Vet Intern Med 2015 Jan;29(1):43-50.
    pmc: PMC4858068pubmed: 25407880doi: 10.1111/jvim.12455google scholar: lookup
  17. Pillon NJ, Azizi PM, Li YE, Liu J, Wang C, Chan KL, Hopperton KE, Bazinet RP, Heit B, Bilan PJ, Lee WL, Klip A. Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis.. Am J Physiol Endocrinol Metab 2015 Jul 1;309(1):E35-44.
    pubmed: 25944880doi: 10.1152/ajpendo.00611.2014google scholar: lookup
  18. Robin CA, Ireland JL, Wylie CE, Collins SN, Verheyen KL, Newton JR. Prevalence of and risk factors for equine obesity in Great Britain based on owner-reported body condition scores.. Equine Vet J 2015 Mar;47(2):196-201.
    pubmed: 24735219doi: 10.1111/evj.12275google scholar: lookup
  19. Tvarijonaviciute A, Ceron JJ, Holden SL, Cuthbertson DJ, Biourge V, Morris PJ, German AJ. Obesity-related metabolic dysfunction in dogs: a comparison with human metabolic syndrome.. BMC Vet Res 2012 Aug 28;8:147.
    pmc: PMC3514388pubmed: 22929809doi: 10.1186/1746-6148-8-147google scholar: lookup
  20. Wang X, Pu H, Ma C, Jiang T, Wei Q, Zhang C, Duan M, Shou X, Su L, Zhang J, Yang Y. Adiponectin abates atherosclerosis by reducing oxidative stress.. Med Sci Monit 2014 Oct 2;20:1792-800.
    pmc: PMC4196893pubmed: 25275545doi: 10.12659/msm.892299google scholar: lookup

Citations

This article has been cited 4 times.
  1. Norton E, Schultz N, Geor R, McFarlane D, Mickelson J, McCue M. Genome-Wide Association Analyses of Equine Metabolic Syndrome Phenotypes in Welsh Ponies and Morgan Horses. Genes (Basel) 2019 Nov 6;10(11).
    doi: 10.3390/genes10110893pubmed: 31698676google scholar: lookup
  2. Durham AE, Frank N, McGowan CM, Menzies-Gow NJ, Roelfsema E, Vervuert I, Feige K, Fey K. ECEIM consensus statement on equine metabolic syndrome. J Vet Intern Med 2019 Mar;33(2):335-349.
    doi: 10.1111/jvim.15423pubmed: 30724412google scholar: lookup
  3. Kusaba A, Tago E, Kusaba H, Kawasumi K. Study of age-related changes in plasma metabolites and enzyme activity of healthy small dogs that underwent medical checkups. Front Vet Sci 2024;11:1437805.
    doi: 10.3389/fvets.2024.1437805pubmed: 39512918google scholar: lookup
  4. Asahi Y, Arai T, Tanaka Y. Changes in plasma metabolite concentrations and enzyme activities in aging riding horses. Front Vet Sci 2024;11:1345548.
    doi: 10.3389/fvets.2024.1345548pubmed: 38881783google scholar: lookup
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