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Open veterinary journal2015; 5(2); 154-157;

Aging effect on plasma metabolites and hormones concentrations in riding horses.

Abstract: Age effects on plasma metabolites, hormone concentrations, and enzyme activities related to energy metabolism were investigated in 20 riding horses. Animals were divided into two groups: Young (3-8 years) and aged (11-18 years). They were clinically healthy, and not obese. Plasma adiponectin (ADN) concentrations in aged horses were significantly lower than those in young horses (mean±SE, 6.5±1.3 µg mL(-1) vs, 10.9±1.7 µg mL(-1), Mann-Whitney U test, respectively; P=0.0233). Plasma non-esterified fatty acid levels and Insulin and malondialdehyde concentrations in aged group tended to increase compared to those in young group although there were not significant differences statistically. In aged group, malate dehydrogenase/lactate dehydrogenase (M/L) ratio, which is considered an energy metabolic indicator, did not change significantly compared to that in young group. Present data suggest that aging may negatively affect nutrition metabolism, but not induce remarkable changes in M/L ratio in riding horses.
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Publication Date: 2015-11-02 PubMed ID: 26623382PubMed Central: PMC4663796
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research discusses the effect of aging on the levels of plasma metabolites, hormones, and certain enzyme activities tied to energy metabolism in riding horses. It suggests that aging in horses may have a negative effect on nutritional metabolism but without significant changes to the energy metabolic indicator (M/L ratio).

Research Methodology

  • The study was conducted on 20 riding horses which were split into two groups. The groups were based on age, with one representing young horses aged 3-8 years and the other aged horses aged 11-18 years.
  • The horses were all clinically healthy and not obese, ensuring the results are not confounded by these factors.

Findings

  • The study found that in aged horses, plasma adiponectin (ADN) concentrations were significantly lower than those in young horses. This was statistically significant with a Mann-Whitney U test (P=0.0233) utilized for the comparison.
  • The study also noticed that plasma non-esterified fatty acid levels, along with Insulin and malondialdehyde concentrations, showed an upward trend in the aged group compared to the young ones. However, the differences noted here were not statistically significant.
  • The researchers found no significant change in malate dehydrogenase/lactate dehydrogenase (M/L) ratio, an energy metabolic indicator, in the aged group as compared to the young group.

Conclusion

  • The findings suggest that, although aging in horses might negatively affect nutrition metabolism, it does not induce substantial changes in their M/L ratio, an energy metabolic indicator.
  • This research provides valuable insights into how aging can affect metabolic processes in horses, with potential implications for how veterinarians and horse owners manage the health and diet of aging horses.

Cite This Article

APA
Kawasumi K, Yamamoto M, Koide M, Okada Y, Mori N, Yamamoto I, Arai T. (2015). Aging effect on plasma metabolites and hormones concentrations in riding horses. Open Vet J, 5(2), 154-157.

Publication

Open veterinary journal
ISSN: 2226-4485
NlmUniqueID: 101653182
Country: Libya
Language: English
Volume: 5
Issue: 2
Pages: 154-157

Researcher Affiliations

Kawasumi, K
  • Department of Basic Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
Yamamoto, M
  • Department of Basic Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
Koide, M
  • Japan Horseback Riding Club, 685-1 Kitanagai Miyoshicho, Iruma-gun, Saitama 354-0044, Japan.
Okada, Y
  • Department of Basic Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
Mori, N
  • Department of Basic Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
Yamamoto, I
  • Department of Basic Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
Arai, T
  • Department of Basic Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.

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Citations

This article has been cited 4 times.
  1. Norton E, Schultz N, Geor R, McFarlane D, Mickelson J, McCue M. Genome-Wide Association Analyses of Equine Metabolic Syndrome Phenotypes in Welsh Ponies and Morgan Horses. Genes (Basel) 2019 Nov 6;10(11).
    doi: 10.3390/genes10110893pubmed: 31698676google scholar: lookup
  2. Durham AE, Frank N, McGowan CM, Menzies-Gow NJ, Roelfsema E, Vervuert I, Feige K, Fey K. ECEIM consensus statement on equine metabolic syndrome. J Vet Intern Med 2019 Mar;33(2):335-349.
    doi: 10.1111/jvim.15423pubmed: 30724412google scholar: lookup
  3. Kusaba A, Tago E, Kusaba H, Kawasumi K. Study of age-related changes in plasma metabolites and enzyme activity of healthy small dogs that underwent medical checkups. Front Vet Sci 2024;11:1437805.
    doi: 10.3389/fvets.2024.1437805pubmed: 39512918google scholar: lookup
  4. Asahi Y, Arai T, Tanaka Y. Changes in plasma metabolite concentrations and enzyme activities in aging riding horses. Front Vet Sci 2024;11:1345548.
    doi: 10.3389/fvets.2024.1345548pubmed: 38881783google scholar: lookup
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