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PloS one2014; 9(1); e85656; doi: 10.1371/journal.pone.0085656

Alarming proportions of methicillin-resistant Staphylococcus aureus (MRSA) in wound samples from companion animals, Germany 2010-2012.

Abstract: Staphylococcus (S.) aureus is an important cause of wound infections in companion animals, and infections with methicillin-resistant S. aureus (MRSA) are of particular concern due to limited treatment options and their zoonotic potential. However, comparable epidemiological data on MRSA infections in dogs, cats and horses is scarce, also limiting the knowledge about possible links to MRSA isolates from human populations. To gain more knowledge about the occurrence and genotypic variation of MRSA among wound swabs of companion animal origin in Germany we performed a survey (2010-2012) including 5,229 samples from 1,170 veterinary practices. S. aureus was identified in 201 (5.8%) canine, 140 (12.2%) feline and 138 (22.8%) equine swabs from a total of 3,479 canine, 1,146 feline and 604 equine wounds, respectively. High MRSA rates were identified with 62.7%, 46.4% and 41.3% in S. aureus of canine, feline and equine origin, respectively. Further genotyping including spa typing and multilocus sequence typing (MLST) revealed a comparable distribution of spa types among canine and feline MRSA with CC22 (47.6%; 49.2%) and CC5 (30.2%; 29.2%) as predominant lineages followed by CC398 (13.5%; 7.7%) and CC8 (4.0%; 9.2%). In contrast, the majority of equine MRSA belonged to CC398 (87.7%). Our data highlight the importance of S. aureus and MRSA as a cause of wound infections, particularly in cats and horses in Germany. While "human-associated" MRSA lineages were most common in dogs and cats, a remarkable number of CC398-MRSA was detected in horses, indicating a replacement of CC8-MRSA as the predominant lineage within horses in Germany. These data enforce further longitudinal epidemiological approaches to examine the diversity and temporal relatedness of MRSA populations in humans and animals to assess probable sources of MRSA infections. This would enable a sound risk assessment and establishment of intervention strategies to limit the additional spread of MRSA.
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Publication Date: 2014-01-20 PubMed ID: 24465637PubMed Central: PMC3896405DOI: 10.1371/journal.pone.0085656Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research explores the occurrence and genetic variation of methicillin-resistant Staphylococcus aureus (MRSA) in wounds of companion animals like dogs, cats, and horses in Germany from 2010-2012. The study reveals alarming proportions of MRSA, especially in cats and horses, with several “human-associated” MRSA lineages prevalent in these animals, pointing to bacteria exchange between humans and pets.

Methodology and Sample Size

  • The study involved a survey conducted from 2010-2012 and included 5,229 samples from 1,170 veterinary practices.
  • The samples were collected from canine, feline, and equine wounds, with a total of 3,479 canine, 1,146 feline, and 604 equine samples.

Findings and Observations

  • The survey results show that Staphylococcus aureus was identified in 201 canine, 140 feline, and 138 equine swabs.
  • Of the S. aureus present in the samples, extraordinary MRSA rates were observed: 62.7% in canines, 46.4% in felines, and 41.3% in equines.
  • Genotypic variations exhibited distribution of spa types among MRSA in canines and felines, with CC22 and CC5 as the dominant lineages, followed by CC398 and CC8.
  • However, in equine samples, the majority of MRSA belonged to CC398, indicating a shift from CC8-MRSA as the dominant lineage in horses.

Implications

  • The research underscores the importance of S. aureus and MRSA as a cause for wound infections, especially in cats and horses in Germany.
  • Furthermore, it points to the existence of “human-associated” MRSA lineages being prevalent in dogs and cats, suggesting possible bacteria exchange between humans and these pets.
  • The study reinforces the need for further longitudinal epidemiological studies to examine the diversity and temporal relatability of MRSA populations in both humans and animals.
  • This will assist in understanding the probable sources of MRSA infections, enabling a sound risk assessment and devising intervention strategies to contain MRSA spread.

Cite This Article

APA
Vincze S, Stamm I, Kopp PA, Hermes J, Adlhoch C, Semmler T, Wieler LH, Lübke-Becker A, Walther B. (2014). Alarming proportions of methicillin-resistant Staphylococcus aureus (MRSA) in wound samples from companion animals, Germany 2010-2012. PLoS One, 9(1), e85656. https://doi.org/10.1371/journal.pone.0085656

Publication

PloS one
ISSN: 1932-6203
NlmUniqueID: 101285081
Country: United States
Language: English
Volume: 9
Issue: 1
Pages: e85656

Researcher Affiliations

Vincze, Szilvia
  • Institute of Microbiology and Epizootics, Veterinary Faculty, Free University Berlin, Germany.
Stamm, Ivonne
  • Vet Med Labor GmbH, Division of IDEXX Laboratories, Ludwigsburg, Germany.
Kopp, Peter A
  • Vet Med Labor GmbH, Division of IDEXX Laboratories, Ludwigsburg, Germany.
Hermes, Julia
  • Department of Infectious Diseases Epidemiology, Robert Koch Institute, Berlin, Germany.
Adlhoch, Cornelia
  • Department of Infectious Diseases Epidemiology, Robert Koch Institute, Berlin, Germany.
Semmler, Torsten
  • Institute of Microbiology and Epizootics, Veterinary Faculty, Free University Berlin, Germany.
Wieler, Lothar H
  • Institute of Microbiology and Epizootics, Veterinary Faculty, Free University Berlin, Germany.
Lübke-Becker, Antina
  • Institute of Microbiology and Epizootics, Veterinary Faculty, Free University Berlin, Germany.
Walther, Birgit
  • Institute of Microbiology and Epizootics, Veterinary Faculty, Free University Berlin, Germany.

MeSH Terms

  • Animals
  • Cats
  • Dogs
  • Germany
  • Horses
  • Incidence
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification
  • Pets / microbiology
  • Staphylococcal Infections / diagnosis
  • Staphylococcal Infections / epidemiology
  • Staphylococcal Infections / veterinary
  • Wounds and Injuries / microbiology
  • Wounds and Injuries / veterinary

Conflict of Interest Statement

Competing Interests: Ivonne Stamm and Peter A. Kopp are employees of IDEXX Vet Med Labor GmbH (Ludwigsburg). The authors\' collaboration partners from VetMed Labor GmbH Ludwigsburg provided the investigated samples for this study. The authors confirm that this does not alter their adherence to all the PLOS ONE policies on sharing data and materials.

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