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Home / Equine Research Bank / J Equine Vet Sci / Alterations in Intestinal Permeability: The Role of the &#82...
Journal of equine veterinary science2017; 52; 10-22; doi: 10.1016/j.jevs.2017.02.009

Alterations in Intestinal Permeability: The Role of the “Leaky Gut” in Health and Disease.

Abstract: All species, including horses, suffer from alterations that increase intestinal permeability. These alterations, also known as "leaky gut," may lead to severe disease as the normal intestinal barrier becomes compromised and can no longer protect against harmful luminal contents including microbial toxins and pathogens. Leaky gut results from a variety of conditions including physical stressors, decreased blood flow to the intestine, inflammatory disease, and pathogenic infections, among others. Several testing methods exist to diagnose these alterations in both a clinical and research setting. To date, most research has focused on regulation of the host immune response due to the wide variety of factors that can potentially influence the intestinal barrier. This article serves to review the normal intestinal barrier, measurement of barrier permeability, pathogenesis and main causes of altered permeability, and highlight potential alternative therapies of leaky gut in horses while relating what has been studied in other species. Conditions resulting in barrier dysfunction and leaky gut can be a major cause of decreased performance and also death in horses. A better understanding of the intestinal barrier in disease and ways to optimize the function of this barrier is vital to the long-term health and maintenance of these animals.
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Publication Date: 2017-03-07 PubMed ID: 31000910PubMed Central: PMC6467570DOI: 10.1016/j.jevs.2017.02.009Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper examines increased intestinal permeability, or “leaky gut,” in horses and its resulting health impacts. The paper reviews the conditions causing this issue, methods of diagnosis, and potential alternative therapies.

Normal Intestinal Barrier and Intestinal Permeability

  • The intestinal barrier serves as a block against any harmful contents in the gut, including toxins and pathogens.
  • A fully functional barrier is crucial for the health and well-being of all vertebrate species, including horses.
  • “Leaky gut” refers to a condition where this barrier is compromised, leading to increased intestinal permeability.
  • Increases in intestinal permeability allow harmful microbial contents to leak from the gut to other parts of the body, potentially causing severe health issues.

Causes of Increased Intestinal Permeability

  • Several conditions can trigger a “leaky gut,” such as physical stress, reduced blood flow to the intestine, inflammatory diseases, and infections from pathogens.
  • Other factors can also influence the stability of the intestinal barrier, which in turn can affect the immune response.

Diagnosing Increased Intestinal Permeability

  • There are several methods available to diagnose increased intestinal permeability, useful in both clinical and research settings.
  • However, there has been a greater focus on investigating how these conditions affect host immune response due to the variety of factors impacting the intestinal barrier.

Alternative Therapies for ‘Leaky Gut’

  • This paper also looks into potential alternative therapies aimed at treating “leaky gut” in horses, drawing comparisons with treatments used in other species.
  • Such therapies are designed to not just treat but also prevent conditions leading to “leaky gut”.

Significance of the Research

  • The malfunctioning of the intestinal barrier and resulting “leaky gut” could lead to decreased performance and even cause death in horses.
  • The research is important as it contributes to a better understanding of the intestinal barrier functions and associated diseases.
  • This understanding is vital for ensuring the long-term health and maintenance of horses.

Cite This Article

APA
Stewart AS, Pratt-Phillips S, Gonzalez LM. (2017). Alterations in Intestinal Permeability: The Role of the “Leaky Gut” in Health and Disease. J Equine Vet Sci, 52, 10-22. https://doi.org/10.1016/j.jevs.2017.02.009

Publication

Journal of equine veterinary science
ISSN: 0737-0806
NlmUniqueID: 8216840
Country: United States
Language: English
Volume: 52
Pages: 10-22

Researcher Affiliations

Stewart, Amy Stieler
  • Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
Pratt-Phillips, Shannon
  • Department of Animal Science, North Carolina State University, Raleigh, NC.
Gonzalez, Liara M
  • Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
  • Center for Gastrointestinal Biology and Disease, Large Animal Models Core, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.

Grant Funding

  • K01 OD019911 / NIH HHS
  • T32 OD011130 / NIH HHS

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Citations

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