Alternative instrumentation for the analysis of total carbon dioxide (TCO(2)) in equine plasma.

The study focuses on finding alternative instruments for total carbon dioxide (TCO2) analysis in equine plasma, as the conventional instrument, Beckman Synchron EL-ISE, is no longer manufactured. The researchers compared several alternatives and found that Beckman Synchron CX 5, DxC 600, and Randox Daytona all met manufacturer specifications and are suitable for routine laboratory use.

Context and Aim of the Study

• The research primarily aims to address the unavailability of Beckman Synchron EL-ISE, the traditional instrument for total carbon dioxide (TCO2) analysis in equine plasma.
• The instrument has reportedly not been supported by its supplier since December 2008, hence the need for alternatives.
• The study attempts to evaluate and commission alternative instrumentation viable for TCO2 analysis in a routine laboratory setting.

Comparison of Alternative Instruments

• The study compares four alternative instruments for TCO2 analysis which are the Beckman Synchron EL-ISE, Beckman Synchron CX5, Beckman UniCel DxC 600, and Randox Daytona.
• Performance evaluation of these tools indicated that they all operate in line with the manufacturer’s specifications and thus can be deemed suitable for a lab environment.

Findings and Conclusions

• Among all the tested tools, only the Randox Daytona instrument was found to be portable enough for onsite use at racecourses.
• On the other hand, Beckman Synchron CX5, DxC 600, and UniCel DxC 600 are suitable for confirmed analysis using the quality-accredited Racing Science Centre’s method.
• The operational principle of the Randox Daytona instrument is questionable for confirmatory analysis.
• Moreover, the cost of these instruments can significantly impact the purchase decision and needs to be considered.