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Home / Equine Research Bank / Acta Vet Scand / An international multi-centre prospective study on the effic...
Acta veterinaria Scandinavica2015; 57(1); 20; doi: 10.1186/s13028-015-0110-6

An international multi-centre prospective study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis: a 24 months follow-up.

Abstract: Polyacrylamide hydrogel (PAAG) was evaluated recently to treat osteoarthritis (OA) in horses with highly encouraging results; however no long term field-study was done to explore its clinical efficacy and lasting effect. The objective of this study was to evaluate the efficacy of PAAG in improving clinical signs of OA in horses. We hypothesized that lameness grade would significantly improve and the effect would last at least 2 years in osteoarthritic joints treated with PAAG. Forty three horses older than 2 years with OA in only one joint based on clinical evaluation, intra-articular anaesthesia and imaging (radiography) were included in this study. Horses were injected with 2 ml of PAAG into the affected joint and were followed up at 1, 3, 6, 12 and 24 months. Efficacy of PAAG was evaluated by blinded clinical assessment of lameness. Adverse reactions to joint injection were assessed. Data relating to case details, type of activity, joint and limb involved, lameness duration, lameness grading, previous joint treatment, joint effusion grading, radiographic grading, and owner assessment were recorded. Factors associated with the outcome measure "lameness grading" were analyzed using generalized linear mixed model for logistic regression. Results: At 1, 3, 6, 12 and 24 months follow-up, 59%, 69%, 79%, 81/% and 82.5% of horses were non-lame respectively. Reduction of joint effusion was observed over time. No side effect was observed in the treated joints. There was a significant decrease in lameness grade from baseline to 1, 3, 6, 12 and 24 months (P < 0.0001) and a significant positive association with joint effusion (P < 0.0001). Estimates for odds ratio (OR) showed that the effect of treatment increased over time (OR for lower lameness from month 1 to month 24 relative to baseline increased from 20 to 58). Conclusions: PAAG significantly alleviated lameness and joint effusion in osteoarthritic joints. PAAG is a safe and lasting (at least 24 months) OA treatment in horses. PAAG is a promising new treatment for OA in horses.
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Publication Date: 2015-04-15 PubMed ID: 25887429PubMed Central: PMC4403890DOI: 10.1186/s13028-015-0110-6Google Scholar: Lookup
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  • Clinical Trial
  • Journal Article
  • Multicenter Study

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research study evaluates a two-year clinical trial on horses suffering from osteoarthritis. The horses were treated with polyacrylamide hydrogel (PAAG), exhibiting significant improvements in terms of lameness and decreased joint effusion, with the treatment’s effect increasing over time.

Methodology

  • The research involved 43 horses aged over two years, all suffering from osteoarthritis in a single joint. The condition was determined through clinical evaluation, intra-articular anaesthesia, and radiographic imaging.
  • The horses were treated with an injection of 2ml of PAAG into the affected joint.
  • The recovery progress was tracked at various stages: 1, 3, 6, 12, and 24 months.
  • The efficacy of PAAG was primarily evaluated through a blinded clinical assessment of lameness. Additionally, any possible adverse reactions to the joint injection were also assessed.
  • Data related to each case, type of activity, affected joint and limb, duration of lameness, grading of lameness and joint effusion, radiographic grading, previous joint treatment, and owner evaluations were recorded for further analysis.

Results

  • At the various stages of the study, the percentage of non-lame horses increased. The percentages at different stages were as follows: 59% (1 month), 69% (3 months), 79% (6 months), 81% (12 months), 82.5% (24 months), suggesting a significant improvement in the health of the osteoarthritic horses treated with PAAG.
  • Joint effusion (excessive accumulation of fluid in the joint) was observed to reduce over time, indicating the positive effects of PAAG.
  • No adverse side effects from the treatment were reported which shows that the PAAG treatment is not only effective, but also safe for the horses.

Statistical Analysis

  • A significant decrease in lameness grade was recorded from baseline to data collection points across 24 months (p < 0.0001), showing the effectiveness of PAAG treatment.
  • The results indicated a positive correlation between PAAG treatment and reduced joint effusion, again reflecting the efficacy of the treatment.
  • The odds ratio (OR) analysis indicated that the treatment effect increased over time, with the OR for lower lameness from the 1st month to the 24th month relative to baseline increasing from 20 to 58.

Conclusion

  • The conclusion of the research indicates that polyacrylamide hydrogel (PAAG) effectively reduces lameness and joint effusion in osteoarthritic horses and that its effects last for at least 24 months.
  • Due to the lack of observed side effects, PAAG was deemed to be a safe treatment option, making it a promising new treatment for osteoarthritis in horses.

Cite This Article

APA
Tnibar A, Schougaard H, Camitz L, Rasmussen J, Koene M, Jahn W, Markussen B. (2015). An international multi-centre prospective study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis: a 24 months follow-up. Acta Vet Scand, 57(1), 20. https://doi.org/10.1186/s13028-015-0110-6

Publication

Acta veterinaria Scandinavica
ISSN: 1751-0147
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 57
Issue: 1
Pages: 20
PII: 20

Researcher Affiliations

Tnibar, Aziz
  • Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Hoejbakkegaard alle 5, DK-2630, Taastrup, Denmark. aztnibar@gmail.com.
Schougaard, Hans
  • Noerlund Hestehospital, Roedebækvej 2, DK-8653, Them, Denmark. mail@hestehospitalet.dk.
Camitz, Linus
  • Camitz equestrian, Aasoe Mosevej 13, DK-4171, Glumsoe, Denmark. camitz@mail.dk.
Rasmussen, Jonas
  • Hoejgaard Hestehospital, Rugaardsvej 696, DK-5462, Morud, Denmark. jr@hoejgaard-hestehospital.dk.
Koene, Marc
  • Tieraerztlische Klinik fuer Pferde, Essener Strasse 39a, D-49456, Bakum, Germany. mkoene@tierklinik-luesche.de.
Jahn, Werner
  • Pferdeklinik Bargteheide, Alte Landstrasse 104, D-22941, Bargteheide, Germany. w.jahn@pferdeklinik-bargteheide.de.
Markussen, Bo
  • Department of Mathematical Sciences, Laboratory of Applied Statistics, University of Copenhagen, Universitetsparken 5, DK-2100, Copenhagen, Denmark. bomar@math.ku.dk.

MeSH Terms

  • Acrylic Resins / pharmacology
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Carpal Joints / pathology
  • Horse Diseases / drug therapy
  • Horses
  • Injections, Intra-Articular / veterinary
  • Lameness, Animal / drug therapy
  • Osteoarthritis / drug therapy
  • Osteoarthritis / veterinary
  • Prospective Studies
  • Tarsal Joints / pathology
  • Time Factors

References

This article includes 28 references
  1. United States Department of Agriculture. Lameness and laminitis in US horses. National Animal Health Monitoring System, 2000.
  2. Caron JP. Osteoarthritis. Diagnosis and Management of Lameness in the Horse 2011;pp. 655–668.
  3. Buckwalter JA, Saltzman C, Brown T. The impact of osteoarthritis: implications for research.. Clin Orthop Relat Res 2004 Oct;(427 Suppl):S6-15.
    doi: 10.1097/01.blo.0000143938.30681.9dpubmed: 15480076google scholar: lookup
  4. McIlwraith CW. Current concepts in equine degenerative joint disease.. J Am Vet Med Assoc 1982 Feb 1;180(3):239-50.
    pubmed: 7035425
  5. McIlwraith CW, Frisbie DD, Kawcak CE. The horse as a model of naturally occurring osteoarthritis.. Bone Joint Res 2012 Nov;1(11):297-309.
    doi: 10.1302/2046-3758.111.2000132pmc: PMC3626203pubmed: 23610661google scholar: lookup
  6. Balazs EA. The Physical Properties of Synovial Fluid and the Special Role of Hyaluronan Acid. Disorders of the Knee 1982;pp. 61–74.
  7. Altman RD. Intra-articular sodium hyaluronate in osteoarthritis of the knee.. Semin Arthritis Rheum 2000 Oct;30(2 Suppl 1):11-8.
    doi: 10.1053/sarh.2000.0248pubmed: 11071577google scholar: lookup
  8. Balazs EA. Viscosupplementation for treatment of osteoarthritis: from initial discovery to current status and results.. Surg Technol Int 2004;12:278-89.
    pubmed: 15455338
  9. Frisbie DD, Kawcak CE, McIlwraith CW, Werpy NM. Evaluation of polysulfated glycosaminoglycan or sodium hyaluronan administered intra-articularly for treatment of horses with experimentally induced osteoarthritis.. Am J Vet Res 2009 Feb;70(2):203-9.
    doi: 10.2460/ajvr.70.2.203pubmed: 19231952google scholar: lookup
  10. Christensen LH, Breiting VB, Aasted A, Jørgensen A, Kebuladze I. Long-term effects of polyacrylamide hydrogel on human breast tissue.. Plast Reconstr Surg 2003 May;111(6):1883-90.
    doi: 10.1097/01.PRS.0000056873.87165.5Apubmed: 12711948google scholar: lookup
  11. Zarini E, Supino R, Pratesi G, Laccabue D, Tortoreto M, Scanziani E, Ghisleni G, Paltrinieri S, Tunesi G, Nava M. Biocompatibility and tissue interactions of a new filler material for medical use.. Plast Reconstr Surg 2004 Sep 15;114(4):934-42.
    doi: 10.1097/01.PRS.0000133425.22598.D0pubmed: 15468401google scholar: lookup
  12. Lloyd AW, Faragher RG, Denyer SP. Ocular biomaterials and implants.. Biomaterials 2001 Apr;22(8):769-85.
    doi: 10.1016/S0142-9612(00)00237-4pubmed: 11246945google scholar: lookup
  13. Fernández-Cossío S, Castaño-Oreja MT. Biocompatibility of two novel dermal fillers: histological evaluation of implants of a hyaluronic acid filler and a polyacrylamide filler.. Plast Reconstr Surg 2006 May;117(6):1789-96.
    doi: 10.1097/01.prs.0000214656.07273.b0pubmed: 16651952google scholar: lookup
  14. Christensen LH, Nielsen JB, Mouritsen L, Sørensen M, Lose G. Tissue integration of polyacrylamide hydrogel: an experimental study of periurethral, perivesical, and mammary gland tissue in the pig.. Dermatol Surg 2008 Jun;34 Suppl 1:S68-77; discussion S77.
    pubmed: 18547185doi: 10.1111/j.1524-4725.2008.34246.xgoogle scholar: lookup
  15. Lose G, Mouritsen L, Nielsen JB. A new bulking agent (polyacrylamide hydrogel) for treating stress urinary incontinence in women.. BJU Int 2006 Jul;98(1):100-4.
    doi: 10.1111/j.1464-410X.2006.06205.xpubmed: 16831152google scholar: lookup
  16. Tnibar A, Schougaard H, Camitz L, Rasmussen J, Koene M, Jahn W. Efficacy of a Polyacrylamide hydrogel in horses with symptomatic osteoarthritis: An International Multi-Centre prospective study [abstract]. Equine Vet J 2012;Suppl 42, 44:s16.
  17. Tnibar A, Schougaard H, Camitz L, Rasmussen J, Koene M, Jahn W. An international multi-centre prospective one year study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis [abstract]. Veterinary Surgery 2014;43(8):s204.
  18. Tnibar A, Persson A, Jensen HE, Svalastoga E, Westrup U, McEvoy F. Evaluation of a polyacrylamide hydrogel in the treatment of induced osteoarthritis in a goat model: A pilot randomized controlled Study [abstract]. Osteoarthritis and Cartilage 2014;22:s477.
    doi: 10.1016/j.joca.2014.02.906google scholar: lookup
  19. Tnibar A, Schougaard H, Koene M, Christensen LH, Markussen B. A controlled clinical trial on the efficacy of an intra-articular Polyacrylamide Hydrogel in horses with osteoarthritis [abstract]. Veterinary Surgery 2014;43(5):s138.
  20. Janssen I, Koene M, Lischer L. Intraartikuläre Applikation von Polyacrylamid Hydrogel zur Behandlung von Osteoarthritis des Hufgelenkes: Fallserie von 12 Pferden. Pferdheilkunde 2012;28:650–656.
  21. Ross MW. Movement. Diagnosis and Management of Lameness in the Horse 2003;pp. 72–79.
  22. Butler JA, Colles CM, Dyson SJ, Kold SE, Poulos PW. Foot, pastern and Fetlock. Carpus. Clinical Radiology of the horse 2008;pp. 53–271.
  23. van Hoogmoed LM, Snyder JR, Thomas HL, Harmon FA. Retrospective evaluation of equine prepurchase examinations performed 1991-2000.. Equine Vet J 2003 Jun;35(4):375-81.
    doi: 10.2746/042516403776014325pubmed: 12880005google scholar: lookup
  24. Elsaid KA, Fleming BC, Oksendahl HL, Machan JT, Fadale PD, Hulstyn MJ, Shalvoy R, Jay GD. Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury.. Arthritis Rheum 2008 Jun;58(6):1707-15.
    doi: 10.1002/art.23495pmc: PMC2789974pubmed: 18512776google scholar: lookup
  25. Flannery CR, Zollner R, Corcoran C, Jones AR, Root A, Rivera-Bermúdez MA, Blanchet T, Gleghorn JP, Bonassar LJ, Bendele AM, Morris EA, Glasson SS. Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin.. Arthritis Rheum 2009 Mar;60(3):840-7.
    doi: 10.1002/art.24304pubmed: 19248108google scholar: lookup
  26. Jay GD, Elsaid KA, Kelly KA, Anderson SC, Zhang L, Teeple E, Waller K, Fleming BC. Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament transection.. Arthritis Rheum 2012 Apr;64(4):1162-71.
    doi: 10.1002/art.33461pmc: PMC3297696pubmed: 22127873google scholar: lookup
  27. Hall MC, Doherty S, Zhang W, Doherty M. Knee joint stiffness and its relationship to severity of radiographic osteoarthritis, pain and self-reported stiffness [abstract]. Osteoarthritis and cartilage 2014;22:s92.
    doi: 10.1016/j.joca.2014.02.178google scholar: lookup
  28. Keegan KG, Dent EV, Wilson DA, Janicek J, Kramer J, Lacarrubba A, Walsh DM, Cassells MW, Esther TM, Schiltz P, Frees KE, Wilhite CL, Clark JM, Pollitt CC, Shaw R, Norris T. Repeatability of subjective evaluation of lameness in horses.. Equine Vet J 2010 Mar;42(2):92-7.
    doi: 10.2746/042516409X479568pubmed: 20156242google scholar: lookup

Citations

This article has been cited 6 times.
  1. Xu F, Dawson C, Lamb M, Mueller E, Stefanek E, Akbari M, Hoare T. Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation.. Front Bioeng Biotechnol 2022;10:849831.
    doi: 10.3389/fbioe.2022.849831pubmed: 35600900google scholar: lookup
  2. Øvrebø Ø, Perale G, Wojciechowski JP, Echalier C, Jeffers JRT, Stevens MM, Haugen HJ, Rossi F. Design and clinical application of injectable hydrogels for musculoskeletal therapy.. Bioeng Transl Med 2022 May;7(2):e10295.
    doi: 10.1002/btm2.10295pubmed: 35600661google scholar: lookup
  3. Velloso Alvarez A, Boone LH, Braim AP, Taintor JS, Caldwell F, Wright JC, Wooldridge AA. A Survey of Clinical Usage of Non-steroidal Intra-Articular Therapeutics by Equine Practitioners.. Front Vet Sci 2020;7:579967.
    doi: 10.3389/fvets.2020.579967pubmed: 33195592google scholar: lookup
  4. Lakin BA, Cooper BG, Zakaria L, Grasso DJ, Wathier M, Bendele AM, Freedman JD, Snyder BD, Grinstaff MW. A Synthetic Bottle-brush Polyelectrolyte Reduces Friction and Wear of Intact and Previously Worn Cartilage.. ACS Biomater Sci Eng 2019 Jun 10;5(6):3060-3067.
    doi: 10.1021/acsbiomaterials.9b00085pubmed: 31608307google scholar: lookup
  5. Wathier M, Lakin BA, Cooper BG, Bansal PN, Bendele AM, Entezari V, Suzuki H, Snyder BD, Grinstaff MW. A synthetic polymeric biolubricant imparts chondroprotection in a rat meniscal tear model.. Biomaterials 2018 Nov;182:13-20.
    doi: 10.1016/j.biomaterials.2018.08.009pubmed: 30099277google scholar: lookup
  6. Cooper BG, Catalina Bordeianu, Nazarian A, Snyder BD, Grinstaff MW. Active agents, biomaterials, and technologies to improve biolubrication and strengthen soft tissues.. Biomaterials 2018 Oct;181:210-226.
    doi: 10.1016/j.biomaterials.2018.07.040pubmed: 30092370google scholar: lookup
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