Analysis of sodium carboxymethylcellulose administration and related factors associated with postoperative colic and survival in horses with small intestinal disease.
Abstract: To analyze the effect of the intraoperative use of sodium carboxymethylcellulose (CBMC) and related perioperative factors on postoperative colic and survival in horses that had abdominal surgery for colic. Methods: Retrospective study. Methods: Horses (n=203) that had surgery for small intestinal disease; 33 horses had intraoperative administration of CBMC. Methods: Information was obtained from medical records for 170 horses that had surgery for colic before use of CBMC and 33 horses that had intraoperative CBMC. Kaplan-Meier survival curves were used to estimate median survival time and a Cox proportional hazards model was used to estimate the hazard ratio for the effect of CBMC and other perioperative variables on survival. Results: Seventy-five percent of horses administered CBMC survived to 180 days, whereas 75% of untreated horses survived 8 days (median survival time=18 days). Horses not administered CBMC were twice as likely to die compared with horses administered CBMC. Horses that had postoperative ileus (POI) were 1.4 times more likely to die than horses without ileus. Similarly, horses with signs of colic after surgery were 1.3 times more likely to die than horses without postoperative signs of colic. Conclusions: CBMC administration is seemingly protective against death and prolongs survival when used intraoperatively in horses with small intestine disease, particularly horses with postoperative colic or POI. Both POI and colic increased risk of death after surgery. Conclusions: Intraoperative administration of CBMC in horses that have surgery for small intestinal disease may improve survival, possibly by reducing early adhesion formation.
Publication Date: 2009-01-13 PubMed ID: 19134106DOI: 10.1111/j.1532-950X.2008.00420.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research analyzes how the use of Sodium Carboxymethylcellulose (CBMC) during surgery impacts post-operative colic and survival rates in horses who have undergone abdominal surgery for colic related to small intestinal disease. Findings underscored that CBMC administration appeared to offer protective benefits and additive survival rate in horses with these conditions, suggesting that it could reduce early adhesion formation.
Study Design and Methods
- This research was a retrospective study that involved a total of 203 horses which had undergone surgical procedures for small intestinal disease.
- Out of these, 33 horses had received intraoperative administration of Sodium Carboxymethylcellulose (CBMC).
- Data for the study was sourced from medical records for 170 horses that had the surgical procedure for colic before the use of CBMC and for the 33 horses who had intraoperative CBMC.
- Utilizing Kaplan-Meier survival curves, the researchers estimated median survival time while a Cox proportional hazards model was used to determine the hazard ratio for the impact of CBMC and other perioperative variables on survival.
Results of the Study
- The results of the study showed that 75% of the horses that were given CBMC survived to 180 days, while a comparative 75% of untreated horses survived for only 8 days. The median survival time was 18 days.
- Horses that were not given CBMC had twice the probability of dying as compared to those administered CBMC.
- Horses that exhibited postoperative ileus (POI) had a 1.4 times higher chance of death than horses without ileus.
- Similarly, horses with signs of colic post-surgery had a 1.3 times higher probability of dying than horses without postoperative colic signs.
Conclusions from the Research
- It emerged from the study that CBMC administration seems to safeguard against death and enhance survival when utilized intraoperatively on horses with small intestine disease, specifically those with postoperative colic or POI.
- Both POI and colic increased the risk of death following surgery.
- The research concluded that intraoperative administration of CBMC in horses undergoing surgery for small intestines disease could improve survival, potentially by minimizing early adhesion formation.
Cite This Article
APA
Fogle CA, Gerard MP, Elce YA, Little D, Morton AJ, Correa MT, Blikslager AT.
(2009).
Analysis of sodium carboxymethylcellulose administration and related factors associated with postoperative colic and survival in horses with small intestinal disease.
Vet Surg, 37(6), 558-563.
https://doi.org/10.1111/j.1532-950X.2008.00420.x Publication
Researcher Affiliations
- Department of Clinical Sciences and Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27606, USA. callie_fogle@ncsu.edu
MeSH Terms
- Animals
- Carboxymethylcellulose Sodium / therapeutic use
- Colic / prevention & control
- Colic / surgery
- Colic / veterinary
- Female
- Horse Diseases / mortality
- Horse Diseases / surgery
- Horses
- Kaplan-Meier Estimate
- Male
- Postoperative Complications / drug therapy
- Postoperative Complications / epidemiology
- Postoperative Complications / mortality
- Postoperative Complications / veterinary
- Proportional Hazards Models
- Retrospective Studies
- Risk Factors
- Time Factors
- Tissue Adhesions / prevention & control
- Tissue Adhesions / veterinary
Citations
This article has been cited 4 times.- Bardell D, Rocchigiani G, Ressel L, Milner P. Histological Evaluation of Resected Tissue as a Predictor of Survival in Horses with Strangulating Small Intestinal Disease. Animals (Basel) 2023 Aug 26;13(17).
- Ruff J, Zetterstrom S, Boone L, Hofmeister E, Smith C, Epstein K, Blikslager A, Fogle C, Burke M. Retrospective analysis of postoperative complications following surgical treatment of ileal impaction in horses managed with manual decompression compared to jejunal enterotomy. Front Vet Sci 2023;10:1156678.
- Alonso Jde M, Alves AL, Watanabe MJ, Rodrigues CA, Hussni CA. Peritoneal response to abdominal surgery: the role of equine abdominal adhesions and current prophylactic strategies. Vet Med Int 2014;2014:279730.
- Du X, Hong G, Sun P, Liu G. Zn2+-SCMC versus HA for preventing intraperitoneal adhesions: a rat model study. Int J Med Sci 2012;9(6):467-71.
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