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Veterinary medicine (Auckland, N.Z.)2012; 3; 53-64; doi: 10.2147/VMRR.S34162

Anesthesia of the geriatric equine.

Abstract: Advancements in veterinary medicine have resulted in an increased number of geriatric horses being presented for medical or surgical procedures that require general anesthesia. Due to the physiological changes associated with aging and the likelihood of concurrent disease conditions, the geriatric equine is at an increased risk during anesthesia. The main physiological changes associated with aging, and their impact on anesthesia, are discussed in this review.
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Publication Date: 2012-08-03 PubMed ID: 30101084PubMed Central: PMC6067663DOI: 10.2147/VMRR.S34162Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the increased risk of anesthesia in geriatric horses due to physiological changes that come with age, as well as the possibility of existing ailments. The focus of the study is on understanding how these changes affect anesthesia.

Objective of the Research

The primary objective of this research was to study and understand the increased risks associated with administering anesthesia to geriatric horses. It explored the physiological changes associated with aging in horses which could potentially impact:

  • The overall health of the equine
  • The safety and efficacy of anesthesia during medical or surgical procedures

    • Reason for the Study

    This study was conducted in response to the increased number of geriatric horses undergoing medical or surgical procedures that require anesthesia. The author noticed that:

    • There have been advancements in veterinary medicine
    • These advancements have resulted in a longer life span for horses
    • As a result, more geriatric horses are being presented for medical or surgical procedures

      • Factors of Increased Risk in Geriatric Horses

      According to the research, two main factors increase the anesthesia risk in geriatric horses:

      • The physiological changes that come with age, which can alter the effect of anesthesia
      • The likelihood of geriatric horses having concurrent disease conditions, which could complicate the anesthesia process and overall health scenario

        • Purpose of the Review

        The review was intended to discuss the main physiological changes associated with aging in horses and how those changes impact anesthesia. This is crucial to understanding how to effectively and safely manage anesthesia in the geriatric equine patient. Key points include:

        • The physiological changes that occur in aging horses
        • How these changes affect the administration of anesthesia
        • How these changes correlate with increased risk during the anesthesia process

Cite This Article

APA
Seddighi R, Doherty TJ. (2012). Anesthesia of the geriatric equine. Vet Med (Auckl), 3, 53-64. https://doi.org/10.2147/VMRR.S34162

Publication

Veterinary medicine (Auckland, N.Z.)
ISSN: 2230-2034
NlmUniqueID: 101724251
Country: New Zealand
Language: English
Volume: 3
Pages: 53-64

Researcher Affiliations

Seddighi, Reza
  • Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Veterinary Medical Center, University of Tennessee, Knoxville, TN, USA, mrsed@utk.edu.
Doherty, Thomas J
  • Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Veterinary Medical Center, University of Tennessee, Knoxville, TN, USA, mrsed@utk.edu.

Conflict of Interest Statement

Disclosure The authors report no conflicts of interest in this work.

References

This article includes 95 references
  1. Sophie S. Anaesthesia for the elderly patient.. J Pak Med Assoc 2007 Apr;57(4):196-201.
    pubmed: 17489529
  2. Doherty TJ. Invited review: Aging and sarcopenia.. J Appl Physiol (1985) 2003 Oct;95(4):1717-27.
    pubmed: 12970377doi: 10.1152/japplphysiol.00347.2003google scholar: lookup
  3. Traub-Dargatz JL, Long RE, Bertone JJ. What is an ‘old horse’ and its recent impact. Equine Geriatric Medicine and Surgery St Louis, MO: Saunders Elsevier; 2006. pp. 1–4.
  4. Donaldson LL. Anesthesia of the geriatric horse. Manual of Equine Anesthesia and Analgesia Ames, IA: Blackwell; 2006. pp. 237–243.
  5. Donaldson LL. Anesthetic Considerations for the Geriatric Equine. Equine Geriatric Medicine and Surgery St Louis, MO: Saunders Elsevier; 2006. pp. 25–37.
  6. Ralston SL, Nockels CF, Squires EL. Differences in diagnostic test results and hematologic data between aged and young horses.. Am J Vet Res 1988 Aug;49(8):1387-92.
    pubmed: 3052193
  7. McFarlane D, Sellon DC, Gaffney D, Hedgpeth V, Papich M, Gibbs S. Hematologic and serum biochemical variables and plasma corticotropin concentration in healthy aged horses.. Am J Vet Res 1998 Oct;59(10):1247-51.
    pubmed: 9781456
  8. Aguilera-Tejero E, Estepa JC, López I, Mayer-Valor R, Rodríguez M. Arterial blood gases and acid-base balance in healthy young and aged horses.. Equine Vet J 1998 Jul;30(4):352-4.
    pubmed: 9705121doi: 10.1111/j.2042-3306.1998.tb04111.xgoogle scholar: lookup
  9. Tasch MD. The autonomic nervous system and geriatric anesthesia.. Int Anesthesiol Clin 1988 Summer;26(2):143-51.
    pubmed: 3290121doi: 10.1097/00004311-198802620-00009google scholar: lookup
  10. Kazmers A, Perkins AJ, Jacobs LA. Outcomes after abdominal aortic aneurysm repair in those > or =80 years of age: recent Veterans Affairs experience.. Ann Vasc Surg 1998 Mar;12(2):106-12.
    pubmed: 9514226doi: 10.1007/s100169900125google scholar: lookup
  11. FISHER MB, BIRREN JE. Age and strength.. J Appl Psychol 1947 Oct;31(5):490-7.
    pubmed: 20267801doi: 10.1037/h0058439google scholar: lookup
  12. Doherty TJ, Brown WF. The estimated numbers and relative sizes of thenar motor units as selected by multiple point stimulation in young and older adults.. Muscle Nerve 1993 Apr;16(4):355-66.
    pubmed: 8455648doi: 10.1002/mus.880160404google scholar: lookup
  13. Evans WJ. Effects of exercise on senescent muscle.. Clin Orthop Relat Res 2002 Oct;(403 Suppl):S211-20.
    pubmed: 12394471doi: 10.1097/00003086-200210001-00025google scholar: lookup
  14. Chakrabarti S, Munshi S, Banerjee K, Thakurta IG, Sinha M, Bagh MB. Mitochondrial Dysfunction during Brain Aging: Role of Oxidative Stress and Modulation by Antioxidant Supplementation.. Aging Dis 2011 Jun;2(3):242-56.
    pmc: PMC3295058pubmed: 22396876
  15. Capucchio MT, Márquez M, Pregel P, Foradada L, Bravo M, Mattutino G, Torre C, Schiffer D, Catalano D, Valenza F, Guarda F, Pumarola M. Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies.. J Comp Pathol 2010 Jan;142(1):61-73.
    pubmed: 19744668doi: 10.1016/j.jcpa.2009.07.007google scholar: lookup
  16. Chételat G, Villemagne VL, Villain N, Jones G, Ellis KA, Ames D, Martins RN, Masters CL, Rowe CC. Accelerated cortical atrophy in cognitively normal elderly with high β-amyloid deposition.. Neurology 2012 Feb 14;78(7):477-84.
    pubmed: 22302548doi: 10.1212/wnl.0b013e318246d67agoogle scholar: lookup
  17. Kline RP, Pirraglia E, Cheng H, De Santi S, Li Y, Haile M, de Leon MJ, Bekker A. Surgery and brain atrophy in cognitively normal elderly subjects and subjects diagnosed with mild cognitive impairment.. Anesthesiology 2012 Mar;116(3):603-12.
    pmc: PMC3418798pubmed: 22293721doi: 10.1097/aln.0b013e318246ec0bgoogle scholar: lookup
  18. Butler RN. Brain preservation.. Geriatrics 1998 Nov;53(11):3-4.
    pubmed: 9824971
  19. Donaldson LL. Retrospective assessment of dobutamine therapy for hypotension in anesthetized horses.. Vet Surg 1988 Jan-Feb;17(1):53-7.
    pubmed: 3256143doi: 10.1111/j.1532-950x.1988.tb00275.xgoogle scholar: lookup
  20. Delorey DS, Clifford PS, Mittelstadt S, Anton MM, Kluess HA, Tune JD, Dincer UD, Buckwalter JB. The effect of aging on adrenergic and nonadrenergic receptor expression and responsiveness in canine skeletal muscle.. J Appl Physiol (1985) 2012 Mar;112(5):841-8.
    pmc: PMC3311660pubmed: 22194325doi: 10.1152/japplphysiol.00945.2011google scholar: lookup
  21. Mooradian AD. Effect of aging on the blood-brain barrier.. Neurobiol Aging 1988 Jan-Feb;9(1):31-9.
    pubmed: 3288893doi: 10.1016/s0197-4580(88)80013-7google scholar: lookup
  22. Gregory GA, Eger EI 2nd, Munson ES. The relationship between age and halothane requirement in man.. Anesthesiology 1969 May;30(5):488-91.
    pubmed: 5778106doi: 10.1097/00000542-196905000-00003google scholar: lookup
  23. YAMASHITA K, IWASAKI Y, UMAR MA, ITAMI T. Effect of age on minimum alveolar concentration (MAC) of sevoflurane in dogs.. J Vet Med Sci 2009 Nov;71(11):1509-12.
    pubmed: 19959903doi: 10.1292/jvms.001509google scholar: lookup
  24. Katoh T, Suguro Y, Ikeda T, Kazama T, Ikeda K. Influence of age on awakening concentrations of sevoflurane and isoflurane.. Anesth Analg 1993 Feb;76(2):348-52.
    pubmed: 8424514
  25. Lerman J, Schmitt-Bantel BI, Gregory GA, Willis MM, Eger EI 2nd. Effect of age on the solubility of volatile anesthetics in human tissues.. Anesthesiology 1986 Sep;65(3):307-11.
    pubmed: 3752575
  26. Lerman J, Gregory GA, Willis MM, Eger EI 2nd. Age and solubility of volatile anesthetics in blood.. Anesthesiology 1984 Aug;61(2):139-43.
    pubmed: 6465597doi: 10.1097/00000542-198408000-00005google scholar: lookup
  27. Magnusson KR, Scanga C, Wagner AE, Dunlop C. Changes in anesthetic sensitivity and glutamate receptors in the aging canine brain.. J Gerontol A Biol Sci Med Sci 2000 Sep;55(9):B448-54.
    pubmed: 10995042doi: 10.1093/gerona/55.9.b448google scholar: lookup
  28. Moller JT, Cluitmans P, Rasmussen LS, Houx P, Rasmussen H, Canet J, Rabbitt P, Jolles J, Larsen K, Hanning CD, Langeron O, Johnson T, Lauven PM, Kristensen PA, Biedler A, van Beem H, Fraidakis O, Silverstein JH, Beneken JE, Gravenstein JS. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction.. Lancet 1998 Mar 21;351(9106):857-61.
    pubmed: 9525362doi: 10.1016/s0140-6736(97)07382-0google scholar: lookup
  29. Monk TG, Weldon BC, Garvan CW, Dede DE, van der Aa MT, Heilman KM, Gravenstein JS. Predictors of cognitive dysfunction after major noncardiac surgery.. Anesthesiology 2008 Jan;108(1):18-30.
    pubmed: 18156878doi: 10.1097/01.anes.0000296071.19434.1egoogle scholar: lookup
  30. Marr CM, Bowen M. Cardiac Disease in the Geriatric Horse. Equine Geriatric Medicine and Surgery St Louis, MO: Saunders Elsevier; 2006. pp. 39–49.
  31. Sage AM. Cardiac disease in the geriatric horse.. Vet Clin North Am Equine Pract 2002 Dec;18(3):575-89, viii.
    pubmed: 12516935doi: 10.1016/s0749-0739(02)00023-8google scholar: lookup
  32. Stevens KB, Marr CM, Horn JN, Pfeiffer DU, Perkins JD, Bowen IM, Allan EJ, Campbell J, Elliott J. Effect of left-sided valvular regurgitation on mortality and causes of death among a population of middle-aged and older horses.. Vet Rec 2009 Jan 3;164(1):6-10.
    pubmed: 19122214doi: 10.1136/vr.164.1.6google scholar: lookup
  33. Rooke GA. Cardiovascular aging and anesthetic implications.. J Cardiothorac Vasc Anesth 2003 Aug;17(4):512-23.
    pubmed: 12968244doi: 10.1016/s1053-0770(03)00161-7google scholar: lookup
  34. Rooke GA. Autonomic and cardiovascular function in the geriatric patient.. Anesthesiol Clin North Am 2000 Mar;18(1):31-46, v-vi.
    pubmed: 10934998doi: 10.1016/s0889-8537(05)70147-4google scholar: lookup
  35. Rooney JR, Robertson JL. Equine Pathology. Ames, IA: Iowa State University Press; 1996.
  36. Amar D, Zhang H, Leung DH, Roistacher N, Kadish AH. Older age is the strongest predictor of postoperative atrial fibrillation.. Anesthesiology 2002 Feb;96(2):352-6.
    pubmed: 11818768doi: 10.1097/00000542-200202000-00021google scholar: lookup
  37. McKeever KH, Malinowski K. Exercise capacity in young and old mares.. Am J Vet Res 1997 Dec;58(12):1468-72.
    pubmed: 9401701
  38. Betros CL, McKeever KH, Kearns CF, Malinowski K. Effects of ageing and training on maximal heart rate and VO2max.. Equine Vet J Suppl 2002 Sep;(34):100-5.
    pubmed: 12405667doi: 10.1111/j.2042-3306.2002.tb05399.xgoogle scholar: lookup
  39. Else RW, Holmes JR. Cardiac pathology in the horse. 1. Gross pathology.. Equine Vet J 1972 Jan;4(1):1-8.
    pubmed: 4650883doi: 10.1111/j.2042-3306.1972.tb03868.xgoogle scholar: lookup
  40. Reef VB. Heart murmurs in horses: determining their significance with echocardiography.. Equine Vet J Suppl 1995 Sep;(19):71-80.
    pubmed: 8933072doi: 10.1111/j.2042-3306.1995.tb04992.xgoogle scholar: lookup
  41. Reef VB, Bain FT, Spencer PA. Severe mitral regurgitation in horses: clinical, echocardiographic and pathological findings.. Equine Vet J 1998 Jan;30(1):18-27.
    pubmed: 9458395doi: 10.1111/j.2042-3306.1998.tb04084.xgoogle scholar: lookup
  42. Lester GD, Lombard CW, Ackerman N. Echocardiographic detection of a dissecting aortic root aneurysm in a thoroughbred stallion. Vet Rad Ultrasound 1992;33(4):202–205.
  43. Marr CM, Reef VB, Brazil TJ, Thomas WP, Knottenbelt DC, Kelly DF, Baker JR, Reimer JM, Maxson AD, Crowhurst JS. Aorto-cardiac fistulas in seven horses.. Vet Radiol Ultrasound 1998 Jan-Feb;39(1):22-31.
    pubmed: 9491514doi: 10.1111/j.1740-8261.1998.tb00321.xgoogle scholar: lookup
  44. Fankhauser R, Luginbühl H, McGrath JT. Cerebrovascular disease in various animal species.. Ann N Y Acad Sci 1965 Sep 8;127(1):817-60.
    pubmed: 5218121doi: 10.1111/j.1749-6632.1965.tb49447.xgoogle scholar: lookup
  45. Rooke GA, Freund PR, Jacobson AF. Hemodynamic response and change in organ blood volume during spinal anesthesia in elderly men with cardiac disease.. Anesth Analg 1997 Jul;85(1):99-105.
    pubmed: 9212130doi: 10.1097/00000539-199707000-00018google scholar: lookup
  46. Sharrock NE, Bading B, Mineo R, Blumenfeld JD. Deliberate hypotensive epidural anesthesia for patients with normal and low cardiac output.. Anesth Analg 1994 Nov;79(5):899-904.
    pubmed: 7978407doi: 10.1213/00000539-199411000-00014google scholar: lookup
  47. Francis JJ. Surgery in the Elderly. Peri-operative Medicine 2nd ed. New York: McGraw-Hill Inc; 1994. pp. 385–394.
  48. Zaugg M, Lucchinetti E. Respiratory function in the elderly.. Anesthesiol Clin North Am 2000 Mar;18(1):47-58, vi.
    pubmed: 10934999doi: 10.1016/s0889-8537(05)70148-6google scholar: lookup
  49. Whitehair KJ, Willits NH. Predictors of arterial oxygen tension in anesthetized horses: 1,610 cases (1992-1994).. J Am Vet Med Assoc 1999 Oct 1;215(7):978-81.
    pubmed: 10511864
  50. Hubbell JA, Aarnes TK, Bednarski RM, Lerche P, Muir WW. Effect of 50% and maximal inspired oxygen concentrations on respiratory variables in isoflurane-anesthetized horses.. BMC Vet Res 2011 Jun 3;7:23.
    pmc: PMC3133541pubmed: 21639886doi: 10.1186/1746-6148-7-23google scholar: lookup
  51. Williamson KK, Davis MS. Evidence-based respiratory medicine in horses.. Vet Clin North Am Equine Pract 2007 Aug;23(2):215-27.
    pubmed: 17616311doi: 10.1016/j.cveq.2007.03.006google scholar: lookup
  52. Davis E, Rush BR. Respiratory Disease in the Geriatric Equine Patient. Equine Geriatric Medicine and Surgery St Louis, MO: Saunders Elsevier; 2006. pp. 179–192.
  53. Robinson NE, Derksen FJ, Olszewski MA, Buechner-Maxwell VA. The pathogenesis of chronic obstructive pulmonary disease of horses.. Br Vet J 1996 May;152(3):283-306.
    pubmed: 8762605doi: 10.1016/s0007-1935(96)80101-1google scholar: lookup
  54. Nyman G, Lindberg R, Weckner D, Björk M, Kvart C, Persson SG, Gustafsson H, Hedenstierna G. Pulmonary gas exchange correlated to clinical signs and lung pathology in horses with chronic bronchiolitis.. Equine Vet J 1991 Jul;23(4):253-60.
    pubmed: 1915223doi: 10.1111/j.2042-3306.1991.tb03713.xgoogle scholar: lookup
  55. Robinson NE. International Workshop on Equine Chronic Airway Disease. Michigan State University 16-18 June 2000.. Equine Vet J 2001 Jan;33(1):5-19.
    pubmed: 11191611doi: 10.2746/042516401776767412google scholar: lookup
  56. Derksen FJ, Olszewski MA, Robinson NE, Berney C, Hakala JE, Matson CJ, Ruth DT. Aerosolized albuterol sulfate used as a bronchodilator in horses with recurrent airway obstruction.. Am J Vet Res 1999 Jun;60(6):689-93.
    pubmed: 10376893
  57. Matera MG, Calzetta L, Rogliani P, Bardaro F, Page CP, Cazzola M. Evaluation of the effects of the R- and S-enantiomers of salbutamol on equine isolated bronchi.. Pulm Pharmacol Ther 2011 Apr;24(2):221-6.
    pubmed: 21195788doi: 10.1016/j.pupt.2010.12.008google scholar: lookup
  58. Brosnahan MM, Paradis MR. Demographic and clinical characteristics of geriatric horses: 467 cases (1989-1999).. J Am Vet Med Assoc 2003 Jul 1;223(1):93-8.
    pubmed: 12839071doi: 10.2460/javma.2003.223.93google scholar: lookup
  59. Evans WJ. What is sarcopenia?. J Gerontol A Biol Sci Med Sci 1995 Nov;50 Spec No:5-8.
    pubmed: 7493218doi: 10.1093/gerona/50a.special_issue.5google scholar: lookup
  60. Welle S. Cellular and molecular basis of age-related sarcopenia.. Can J Appl Physiol 2002 Feb;27(1):19-41.
    pubmed: 11880689doi: 10.1139/h02-002google scholar: lookup
  61. Freeman LM. Cachexia and sarcopenia: emerging syndromes of importance in dogs and cats.. J Vet Intern Med 2012 Jan-Feb;26(1):3-17.
    pubmed: 22111652doi: 10.1111/j.1939-1676.2011.00838.xgoogle scholar: lookup
  62. Doherty TJ, Vandervoort AA, Brown WF. Effects of ageing on the motor unit: a brief review.. Can J Appl Physiol 1993 Dec;18(4):331-58.
    pubmed: 8275048doi: 10.1139/h93-029google scholar: lookup
  63. Porter MM, Vandervoort AA, Lexell J. Aging of human muscle: structure, function and adaptability.. Scand J Med Sci Sports 1995 Jun;5(3):129-42.
    pubmed: 7552755doi: 10.1111/j.1600-0838.1995.tb00026.xgoogle scholar: lookup
  64. Larsson L, Yu F, Höök P, Ramamurthy B, Marx JO, Pircher P. Effects of aging on regulation of muscle contraction at the motor unit, muscle cell, and molecular levels.. Int J Sport Nutr Exerc Metab 2001 Dec;11 Suppl:S28-43.
    pubmed: 11915925doi: 10.1123/ijsnem.11.s1.s28google scholar: lookup
  65. Alnaqeeb MA, Goldspink G. Changes in fibre type, number and diameter in developing and ageing skeletal muscle.. J Anat 1987 Aug;153:31-45.
    pmc: PMC1261780pubmed: 3429325
  66. Hooper AC. Length, diameter and number of ageing skeletal muscle fibres.. Gerontology 1981;27(3):121-6.
    pubmed: 7239169doi: 10.1159/000212459google scholar: lookup
  67. Campbell MJ, McComas AJ, Petito F. Physiological changes in ageing muscles.. J Neurol Neurosurg Psychiatry 1973 Apr;36(2):174-82.
    pmc: PMC1083551pubmed: 4708452doi: 10.1136/jnnp.36.2.174google scholar: lookup
  68. Larsson L, Salviati G. Effects of age on calcium transport activity of sarcoplasmic reticulum in fast- and slow-twitch rat muscle fibres.. J Physiol 1989 Dec;419:253-64.
    pmc: PMC1190007pubmed: 2621631doi: 10.1113/jphysiol.1989.sp017872google scholar: lookup
  69. Kenney WL, Buskirk ER. Functional consequences of sarcopenia: effects on thermoregulation.. J Gerontol A Biol Sci Med Sci 1995 Nov;50 Spec No:78-85.
    pubmed: 7493224doi: 10.1093/gerona/50a.special_issue.78google scholar: lookup
  70. Messer NT 4th, Johnson PJ. Evidence-based literature pertaining to thyroid dysfunction and Cushing's syndrome in the horse.. Vet Clin North Am Equine Pract 2007 Aug;23(2):329-64.
    pubmed: 17616317doi: 10.1016/j.cveq.2007.04.004google scholar: lookup
  71. van der Kolk H. Diseases of the pituitary gland, including hyperadrenocorticism. Metabolic and Endocrine Problems of the Horse New York: WB Saunders; 1998.
  72. Love S. Equine Cushing's disease.. Br Vet J 1993 Mar-Apr;149(2):139-53.
    pubmed: 8485640doi: 10.1016/s0007-1935(05)80084-3google scholar: lookup
  73. Lampe GH, Roizen MF. Anesthesia for patients with abnormal function of the adrenal cortex. Anesth Clin North Am 1987;5(2):245–267.
  74. Dybdal N, Levy M. Pituitary pars intermedia dysfunction in the horse. Part II: diagnosis and treatment. Presented at the 15th Annual Forum of the College of Veterinary Internal Medicine; Lake Buena Vista, FL. 1997.
  75. Donaldson MT, LaMonte BH, Morresey P, Smith G, Beech J. Treatment with pergolide or cyproheptadine of pituitary pars intermedia dysfunction (equine Cushing's disease).. J Vet Intern Med 2002 Nov-Dec;16(6):742-6.
    pubmed: 12465775doi: 10.1892/0891-6640(2002)016<0742:twpoco>2.3.co;2google scholar: lookup
  76. Sojka JE. Hypothyroidism in horses. Compend Contin Edu Prac Vet 1995;17:845–852.
  77. Vischer CM, Foreman JH, Constable PD, Benson GJ, Kline KH, Freeman DE, Campbell KL, Grubb TL. Hemodynamic effects of thyroidectomy in sedentary horses.. Am J Vet Res 1999 Jan;60(1):14-21.
    pubmed: 9918143
  78. Frank N, Sommardahl CS, Eiler H, Webb LL, Denhart JW, Boston RC. Effects of oral administration of levothyroxine sodium on concentrations of plasma lipids, concentration and composition of very-low-density lipoproteins, and glucose dynamics in healthy adult mares.. Am J Vet Res 2005 Jun;66(6):1032-8.
    pubmed: 16008228doi: 10.2460/ajvr.2005.66.1032google scholar: lookup
  79. Shafer SL. The pharmacology of anesthetic drugs in elderly patients.. Anesthesiol Clin North Am 2000 Mar;18(1):1-29, v.
    pubmed: 10934997doi: 10.1016/s0889-8537(05)70146-2google scholar: lookup
  80. Barnhill JG, Greenblatt DJ, Miller LG, Gaver A, Harmatz JS, Shader RI. Kinetic and dynamic components of increased benzodiazepine sensitivity in aging animals.. J Pharmacol Exp Ther 1990 Jun;253(3):1153-61.
    pubmed: 2162948
  81. Schnider TW, Minto CF, Shafer SL, Gambus PL, Andresen C, Goodale DB, Youngs EJ. The influence of age on propofol pharmacodynamics.. Anesthesiology 1999 Jun;90(6):1502-16.
    pubmed: 10360845doi: 10.1097/00000542-199906000-00003google scholar: lookup
  82. Stanski DR, Maitre PO. Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited.. Anesthesiology 1990 Mar;72(3):412-22.
    pubmed: 2310020doi: 10.1097/00000542-199003000-00003google scholar: lookup
  83. Delp MD, Evans MV, Duan C. Effects of aging on cardiac output, regional blood flow, and body composition in Fischer-344 rats.. J Appl Physiol (1985) 1998 Nov;85(5):1813-22.
    pubmed: 9804586doi: 10.1152/jappl.1998.85.5.1813google scholar: lookup
  84. Mrak RE, Griffin ST, Graham DI. Aging-associated changes in human brain.. J Neuropathol Exp Neurol 1997 Dec;56(12):1269-75.
    pubmed: 9413275doi: 10.1097/00005072-199712000-00001google scholar: lookup
  85. Magnusson KR. Differential effects of aging on binding sites of the activated NMDA receptor complex in mice.. Mech Ageing Dev 1995 Oct 27;84(3):227-43.
    pubmed: 8788777doi: 10.1016/0047-6374(95)01658-9google scholar: lookup
  86. Gupta DK, Henthorn TK. Pharmacologic principles. Clinical Anesthesia Philadelphia, PA: Lippincott Williams & Wilkins; 2009. pp. 143–144.
  87. Landrum AL. Use of intravenous techniques in the elderly. Textbook of Intravenous Anesthesia Baltimore, MD: Lippincott Williams & Wilkins; 1997.
  88. Macklon AF, Barton M, James O, Rawlins MD. The effect of age on the pharmacokinetics of diazepam.. Clin Sci (Lond) 1980 Dec;59(6):479-83.
    pubmed: 7438711doi: 10.1042/cs0590479google scholar: lookup
  89. Bromage PR. Ageing and epidural dose requirements: segmental spread and predictability of epidural analgesia in youth and extreme age.. Br J Anaesth 1969 Dec;41(12):1016-22.
    pubmed: 5365518doi: 10.1093/bja/41.12.1016google scholar: lookup
  90. Johnston GM, Eastment JK, Wood J, Taylor PM. The confidential enquiry into perioperative equine fatalities (CEPEF): mortality results of Phases 1 and 2.. Vet Anaesth Analg 2002 Oct;29(4):159-170.
    pubmed: 28404360doi: 10.1046/j.1467-2995.2002.00106.xgoogle scholar: lookup
  91. Bidwell LA, Bramlage LR, Rood WA. Equine perioperative fatalities associated with general anaesthesia at a private practice--a retrospective case series.. Vet Anaesth Analg 2007 Jan;34(1):23-30.
    pubmed: 17238959doi: 10.1111/j.1467-2995.2005.00283.xgoogle scholar: lookup
  92. Glade MJ. Effects of gestation, lactation, and maternal calcium intake on mechanical strength of equine bone.. J Am Coll Nutr 1993 Aug;12(4):372-7.
    pubmed: 8409098doi: 10.1080/07315724.1993.10718325google scholar: lookup
  93. Jernigan AD, Wilson RC, Booth NH, Hatch RC, Akbari A. Comparative pharmacokinetics of yohimbine in steers, horses and dogs.. Can J Vet Res 1988 Apr;52(2):172-6.
    pmc: PMC1255422pubmed: 3370551
  94. Malan TP Jr, DiNardo JA, Isner RJ, Frink EJ Jr, Goldberg M, Fenster PE, Brown EA, Depa R, Hammond LC, Mata H. Cardiovascular effects of sevoflurane compared with those of isoflurane in volunteers.. Anesthesiology 1995 Nov;83(5):918-28.
    pubmed: 7486177doi: 10.1097/00000542-199511000-00004google scholar: lookup
  95. Bernard JM, Wouters PF, Doursout MF, Florence B, Chelly JE, Merin RG. Effects of sevoflurane and isoflurane on cardiac and coronary dynamics in chronically instrumented dogs.. Anesthesiology 1990 Apr;72(4):659-62.
    pubmed: 2321783doi: 10.1097/00000542-199004000-00014google scholar: lookup

Citations

This article has been cited 1 times.
  1. Laurenza C, Ansart L, Portier K. Risk Factors of Anesthesia-Related Mortality and Morbidity in One Equine Hospital: A Retrospective Study on 1,161 Cases Undergoing Elective or Emergency Surgeries. Front Vet Sci 2019;6:514.
    doi: 10.3389/fvets.2019.00514pubmed: 32039253google scholar: lookup
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