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Home / Equine Research Bank / Biomed Res Int / Anthelmintic Resistance of Strongyle Nematodes to Ivermectin...
BioMed research international2017; 2017; 5163968; doi: 10.1155/2017/5163968

Anthelmintic Resistance of Strongyle Nematodes to Ivermectin and Fenbendazole on Cart Horses in Gondar, Northwest Ethiopia.

Abstract: A study was conducted from November 2015 to April 2016 to determine fenbendazole and ivermectin resistance status of intestinal nematodes of cart horses in Gondar, Northwest Ethiopia. Forty-five strongyle infected animals were used for this study. The animals were randomly allocated into three groups (15 horses per group). Group I was treated with fenbendazole and Group II with ivermectin and Group III was left untreated. Faecal samples were collected from each cart horse before and after treatment. Accordingly, the reduction in the mean fecal egg count at fourteen days of treatment for ivermectin and fenbendazole was 97.25% and 79.4%, respectively. It was significantly different in net egg count between treatment and control groups after treatment. From the study, resistance level was determined for fenbendazole and suspected for ivermectin. In addition, a questionnaire survey was also conducted on 90 selected cart owners to assess their perception on anthelmintics. In the survey, the most available drugs in the study area used by the owners were fenbendazole and ivermectin. Most respondents have no knowledge about drug management techniques. Hence, animal health extension services to create awareness regarding anthelmintic management that plays a key role in reducing the anthelmintic resistance parasites.
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Publication Date: 2017-02-07 PubMed ID: 28265572PubMed Central: PMC5318625DOI: 10.1155/2017/5163968Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research looks into resistance against two common deworming drugs, fenbendazole and ivermectin, in parasitic worms found in cart horses in Gondar, northwest Ethiopia. The report suggests fenbendazole had higher evidence of resistance, while possible ivermectin resistance was noticed, recommending education on deworming for local horse owners.

Research and Methodology

  • The researchers conducted the study between November 2015 and April 2016. The study specifically looked into intestinal nematodes (a type of parasitic worm) in cart horses.
  • A total of 45 horses, all of which were infested with a type of worm called strongyle, were divided into three groups of 15 horses each.
  • The first group was treated with fenbendazole, the second with ivermectin, both common deworming drugs. The third group was not treated and served as the control group for comparison.

Findings

  • Before and after treatment, fecal samples were collected from the horses to assess the number of parasite eggs.
  • A significant reduction in the fecal egg count was noted in both treatment groups compared to the untreated group. The decrease in the average fecal egg count 14 days post-treatment was 97.25% for the group treated with ivermectin and 79.4% for the group treated with fenbendazole.
  • The greater reduction in the ivermectin group and the comparatively smaller reduction in the fenbendazole group indicated that the parasites had developed a higher level of resistance to fenbendazole and a suspected level of resistance to ivermectin.

Questionnaire Survey

  • In addition to the resistance study, the researchers also conducted a questionnaire survey among 90 selected cart horse owners to understand their awareness and perception about deworming drugs.
  • It turned out that while fenbendazole and ivermectin were the most accessible drugs in the region, many horse owners had limited knowledge about their correct use and management.

Recommendations

  • The study concludes with a recommendation for increased animal health education initiatives to raise awareness about the correct use of deworming drugs and strategies to reduce parasite resistance to these drugs.

Cite This Article

APA
Seyoum Z, Zewdu A, Dagnachew S, Bogale B. (2017). Anthelmintic Resistance of Strongyle Nematodes to Ivermectin and Fenbendazole on Cart Horses in Gondar, Northwest Ethiopia. Biomed Res Int, 2017, 5163968. https://doi.org/10.1155/2017/5163968

Publication

BioMed research international
ISSN: 2314-6141
NlmUniqueID: 101600173
Country: United States
Language: English
Volume: 2017
Pages: 5163968
PII: 5163968

Researcher Affiliations

Seyoum, Zewdu
  • Department of Paraclinical Studies, Faculty of Veterinary Medicine, University of Gondar, Gondar, Ethiopia.
Zewdu, Alemu
  • Department of Paraclinical Studies, Faculty of Veterinary Medicine, University of Gondar, Gondar, Ethiopia.
Dagnachew, Shimelis
  • Department of Paraclinical Studies, Faculty of Veterinary Medicine, University of Gondar, Gondar, Ethiopia.
Bogale, Basazinew
  • Department of Paraclinical Studies, Faculty of Veterinary Medicine, University of Gondar, Gondar, Ethiopia.

MeSH Terms

  • Animals
  • Drug Resistance
  • Ethiopia / epidemiology
  • Horses / parasitology
  • Ivermectin / pharmacology
  • Strongyle Infections, Equine / drug therapy
  • Strongyle Infections, Equine / epidemiology
  • Strongylus

Conflict of Interest Statement

The authors declare that there is no conflict of interests regarding the publication of this paper.

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Citations

This article has been cited 4 times.
  1. Fesseha H, Aliye S, Mathewos M, Nigusie K. Prevalence and risk factors associated with donkey gastrointestinal parasites in Shashemane and Suburbs, Oromia Region, Ethiopia. Heliyon 2022 Dec;8(12):e12244.
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  2. Fesseha H, Mathewos M, Kidanemariam F. Anthelmintic Efficacy of Strongyle Nematodes to Ivermectin and Fenbendazole on Working Donkeys (Equus asinus) in and around Hosaena Town, Southern Ethiopia. Vet Med Int 2020;2020:4868797.
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  4. Nielsen MK. Anthelmintic resistance in equine nematodes: Current status and emerging trends. Int J Parasitol Drugs Drug Resist 2022 Dec;20:76-88.
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