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Journal of the American Veterinary Medical Association2006; 228(5); 706-655; doi: 10.2460/javma.228.5.706

Antimicrobial regional limb perfusion in horses.

Abstract: Regional limb perfusion involves administration of an antimicrobial solution into the vasculature of a selected portion of the limb that has been isolated from the systemic circulation by controlled application of a tourniquet. The technique provides high antimicrobial concentrations in the region of interest and greatly contributes to the elimination of infection.
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Publication Date: 2006-03-02 PubMed ID: 16506931DOI: 10.2460/javma.228.5.706Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research looks at the usage of antimicrobial regional limb perfusion in horses where an antimicrobial solution is applied directly to a specific limb area to fight off infections.

Research Overview

In this research, scientists sought to examine the efficacy of a procedure known as “regional limb perfusion” (RLP) in treating infections in horses. Specifically, they administered an antimicrobial solution into a selected part of a horse’s limb that was isolated with a tourniquet, allowing for targeted treatment and avoiding the systemic overload of the medicine.

The Method

  • Regional limb perfusion is a medical technique that allows for highly concentrated medicine to reach the ailment point. In the case of the study, the area affected by an infection.
  • The RLP technique involves the use of a tourniquet to isolate a specific portion of the limb from the rest of the body’s circulation.
  • Once isolated, the antimicrobial solution is administered directly into the vasculature of the isolated section. This allows the solution to concentrate in the area, potentially providing a more effective defense against the infection.

Results and Benefits

  • By employing this procedure, the researchers were able to introduce high concentrations of antimicrobials into the area of interest. This technique greatly assists in eliminating any present infection, thus promoting the animal’s recovery.
  • One significant advantage of this type of targeted treatment is that it potentially reduces the risks and side effects related to systemic administration of antimicrobials, giving it a higher preference in veterinary practice.

Cite This Article

APA
Rubio-Martínez LM, Cruz AM. (2006). Antimicrobial regional limb perfusion in horses. J Am Vet Med Assoc, 228(5), 706-655. https://doi.org/10.2460/javma.228.5.706

Publication

Journal of the American Veterinary Medical Association
ISSN: 0003-1488
NlmUniqueID: 7503067
Country: United States
Language: English
Volume: 228
Issue: 5
Pages: 706-655

Researcher Affiliations

Rubio-Martínez, Luis M
  • Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
Cruz, Antonio M

    MeSH Terms

    • Animals
    • Anti-Bacterial Agents / administration & dosage
    • Anti-Bacterial Agents / pharmacokinetics
    • Dose-Response Relationship, Drug
    • Horse Diseases / drug therapy
    • Horses
    • Infusions, Intraosseous / veterinary
    • Infusions, Intravenous / veterinary
    • Perfusion / methods
    • Perfusion / veterinary
    • Treatment Outcome

    Citations

    This article has been cited 18 times.
    1. Celani G, Straticò P, Albano P, Petrizzi L, Mortellaro CM, Varasano V. Clinical Efficacy of a Single Intravenous Regional Limb Perfusion with Marbofloxacin versus Ceftiofur Sodium to Treat Acute Interdigital Phlegmon in Dairy Cows. Animals (Basel) 2023 May 10;13(10).
      doi: 10.3390/ani13101598pubmed: 37238027google scholar: lookup
    2. Mizuguchi Y, Kato A, Aizu M. Regional antibiotic perfusion through the lateral saphenous vein in two horses with septic calcaneal osteitis. J Vet Med Sci 2023 Jan 6;85(1):55-61.
      doi: 10.1292/jvms.22-0377pubmed: 36418075google scholar: lookup
    3. Redding LE, Elzer EJ, Ortved KF. Effects of regional limb perfusion technique on concentrations of antibiotic achieved at the target site: A meta-analysis. PLoS One 2022;17(4):e0265971.
      doi: 10.1371/journal.pone.0265971pubmed: 35363825google scholar: lookup
    4. Huckins GL, Sim RR, Hartup B. Adjunctive Use of Intravenous Antibiotic Regional Limb Perfusion in Three Cranes with Distal Limb Infections. Animals (Basel) 2021 Sep 12;11(9).
      doi: 10.3390/ani11092673pubmed: 34573640google scholar: lookup
    5. Bonilla AG, Causeret L, Torrent-Crosa A. Pharmacokinetics of ceftiofur in the metacarpophalangeal joint after standing intravenous regional limb perfusion in horses. Can Vet J 2021 Sep;62(9):975-981.
      pubmed: 34475583
    6. Gustafsson K, Tatz AJ, Dahan R, Abu Ahmad W, Britzi M, Sutton GA, Kelmer G. Synovial Concentration of Trimethoprim-Sulphadiazine Following Regional Limb Perfusion in Standing Horses. Animals (Basel) 2021 Jul 13;11(7).
      doi: 10.3390/ani11072085pubmed: 34359213google scholar: lookup
    7. Mosichuk AP, Smith JS, Tatarniuk DM, Troy JR, Kreuder AJ. Meropenem Administered via Intravenous Regional Limb Perfusion for Orthopedic Sepsis in Horses: A Clinical Retrospective Study. Front Vet Sci 2021;8:629627.
      doi: 10.3389/fvets.2021.629627pubmed: 33842571google scholar: lookup
    8. Russell KA, Garbin LC, Wong JM, Koch TG. Mesenchymal Stromal Cells as Potential Antimicrobial for Veterinary Use-A Comprehensive Review. Front Microbiol 2020;11:606404.
      doi: 10.3389/fmicb.2020.606404pubmed: 33335522google scholar: lookup
    9. Merkatoris P, Schleining J, Krull A, Borts D, Fajt V. In vitro Elution of Penicillin, Ampicillin, Tetracycline, Tulathromycin, and Florfenicol From Plaster of Paris Beads. Front Vet Sci 2020;7:585423.
      doi: 10.3389/fvets.2020.585423pubmed: 33330710google scholar: lookup
    10. Dahan R, Oreff GL, Tatz AJ, Raz T, Britzi M, Kelmer G. Pharmacokinetics of regional limb perfusion using a combination of amikacin and penicillin in standing horses. Can Vet J 2019 Mar;60(3):294-299.
      pubmed: 30872853
    11. Celani G, Tulini SMR, Montesano C, Zezza D, Sergi M, Varasano V, Mortellaro CM, Compagnone D, Amorena M, Petrizzi L. Pharmacokinetics of marbofloxacin administered via intravenous regional limb perfusion in dairy cows: evaluation of two different tourniquets. Vet Rec Open 2017;4(1):e000227.
      doi: 10.1136/vetreco-2017-000227pubmed: 29018533google scholar: lookup
    12. Spugnini EP, Bolaffio C, Scacco L, Baldi A. Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare. Open Vet J 2017;7(2):192-196.
      doi: 10.4314/ovj.v7i2.18pubmed: 28717603google scholar: lookup
    13. Nieto JE, Trela J, Stanley SD, Yamout S, Snyder JR. Pharmacokinetics of a combination of amikacin sulfate and penicillin G sodium for intravenous regional limb perfusion in adult horses. Can J Vet Res 2016 Jul;80(3):230-5.
      pubmed: 27408337
    14. Dória RG, Carvalho MB, Freitas SH, Laskoski LM, Colodel EM, Mendonça FS, Silva MA, Grigoletto R, Fantinato Neto P. Evaluation of intravenous regional perfusion with amphotericin B and dimethylsulfoxide to treat horses for pythiosis of a limb. BMC Vet Res 2015 Jul 16;11:152.
      doi: 10.1186/s12917-015-0472-zpubmed: 26174778google scholar: lookup
    15. Hunter BG, Duesterdieck-Zellmer KF, Larson MK. Tiludronate concentrations and cytologic findings in synovial fluid after intravenous regional limb perfusion with tiludronate in horses. PeerJ 2015;3:e889.
      doi: 10.7717/peerj.889pubmed: 25945303google scholar: lookup
    16. Hyde RM, Lynch TM, Clark CK, Slone DE, Hughes FE. The influence of perfusate volume on antimicrobial concentration in synovial fluid following intravenous regional limb perfusion in the standing horse. Can Vet J 2013 Apr;54(4):363-7.
      pubmed: 24082163
    17. Guillot M, Mespoulhes-Rivière C, Bousquet-Mélou A, Lacroix MZ, Roques BB, Lallemand EA. Pharmacokinetics, pharmacodynamics, and local tolerance at injection site of penicillin and gentamicin administered by intravenous regional limb perfusion in standing horses: comparison between weightbearing and flexed limbs. BMC Vet Res 2025 Nov 7;21(1):650.
      doi: 10.1186/s12917-025-04936-0pubmed: 41204239google scholar: lookup
    18. Albanese V, Straticò P, Fischer H, Petrizzi L. Equine Distal Limb Wounds: Economic Impact and Short-Term Prognosis of Non-Synovial Versus Synovial Lesions in Southern Germany. Vet Sci 2025 Mar 1;12(3).
      doi: 10.3390/vetsci12030205pubmed: 40266953google scholar: lookup
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