Antimicrobial regional limb perfusion in horses.
Abstract: Regional limb perfusion involves administration of an antimicrobial solution into the vasculature of a selected portion of the limb that has been isolated from the systemic circulation by controlled application of a tourniquet. The technique provides high antimicrobial concentrations in the region of interest and greatly contributes to the elimination of infection.
Publication Date: 2006-03-02 PubMed ID: 16506931DOI: 10.2460/javma.228.5.706Google Scholar: Lookup
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Summary
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The research looks at the usage of antimicrobial regional limb perfusion in horses where an antimicrobial solution is applied directly to a specific limb area to fight off infections.
Research Overview
In this research, scientists sought to examine the efficacy of a procedure known as “regional limb perfusion” (RLP) in treating infections in horses. Specifically, they administered an antimicrobial solution into a selected part of a horse’s limb that was isolated with a tourniquet, allowing for targeted treatment and avoiding the systemic overload of the medicine.
The Method
- Regional limb perfusion is a medical technique that allows for highly concentrated medicine to reach the ailment point. In the case of the study, the area affected by an infection.
- The RLP technique involves the use of a tourniquet to isolate a specific portion of the limb from the rest of the body’s circulation.
- Once isolated, the antimicrobial solution is administered directly into the vasculature of the isolated section. This allows the solution to concentrate in the area, potentially providing a more effective defense against the infection.
Results and Benefits
- By employing this procedure, the researchers were able to introduce high concentrations of antimicrobials into the area of interest. This technique greatly assists in eliminating any present infection, thus promoting the animal’s recovery.
- One significant advantage of this type of targeted treatment is that it potentially reduces the risks and side effects related to systemic administration of antimicrobials, giving it a higher preference in veterinary practice.
Cite This Article
APA
Rubio-Martínez LM, Cruz AM.
(2006).
Antimicrobial regional limb perfusion in horses.
J Am Vet Med Assoc, 228(5), 706-655.
https://doi.org/10.2460/javma.228.5.706 Publication
Researcher Affiliations
- Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
MeSH Terms
- Animals
- Anti-Bacterial Agents / administration & dosage
- Anti-Bacterial Agents / pharmacokinetics
- Dose-Response Relationship, Drug
- Horse Diseases / drug therapy
- Horses
- Infusions, Intraosseous / veterinary
- Infusions, Intravenous / veterinary
- Perfusion / methods
- Perfusion / veterinary
- Treatment Outcome
Citations
This article has been cited 16 times.- Celani G, Straticò P, Albano P, Petrizzi L, Mortellaro CM, Varasano V. Clinical Efficacy of a Single Intravenous Regional Limb Perfusion with Marbofloxacin versus Ceftiofur Sodium to Treat Acute Interdigital Phlegmon in Dairy Cows.. Animals (Basel) 2023 May 10;13(10).
- Mizuguchi Y, Kato A, Aizu M. Regional antibiotic perfusion through the lateral saphenous vein in two horses with septic calcaneal osteitis.. J Vet Med Sci 2023 Jan 6;85(1):55-61.
- Redding LE, Elzer EJ, Ortved KF. Effects of regional limb perfusion technique on concentrations of antibiotic achieved at the target site: A meta-analysis.. PLoS One 2022;17(4):e0265971.
- Huckins GL, Sim RR, Hartup B. Adjunctive Use of Intravenous Antibiotic Regional Limb Perfusion in Three Cranes with Distal Limb Infections.. Animals (Basel) 2021 Sep 12;11(9).
- Bonilla AG, Causeret L, Torrent-Crosa A. Pharmacokinetics of ceftiofur in the metacarpophalangeal joint after standing intravenous regional limb perfusion in horses.. Can Vet J 2021 Sep;62(9):975-981.
- Gustafsson K, Tatz AJ, Dahan R, Abu Ahmad W, Britzi M, Sutton GA, Kelmer G. Synovial Concentration of Trimethoprim-Sulphadiazine Following Regional Limb Perfusion in Standing Horses.. Animals (Basel) 2021 Jul 13;11(7).
- Mosichuk AP, Smith JS, Tatarniuk DM, Troy JR, Kreuder AJ. Meropenem Administered via Intravenous Regional Limb Perfusion for Orthopedic Sepsis in Horses: A Clinical Retrospective Study.. Front Vet Sci 2021;8:629627.
- Russell KA, Garbin LC, Wong JM, Koch TG. Mesenchymal Stromal Cells as Potential Antimicrobial for Veterinary Use-A Comprehensive Review.. Front Microbiol 2020;11:606404.
- Merkatoris P, Schleining J, Krull A, Borts D, Fajt V. In vitro Elution of Penicillin, Ampicillin, Tetracycline, Tulathromycin, and Florfenicol From Plaster of Paris Beads.. Front Vet Sci 2020;7:585423.
- Dahan R, Oreff GL, Tatz AJ, Raz T, Britzi M, Kelmer G. Pharmacokinetics of regional limb perfusion using a combination of amikacin and penicillin in standing horses.. Can Vet J 2019 Mar;60(3):294-299.
- Celani G, Tulini SMR, Montesano C, Zezza D, Sergi M, Varasano V, Mortellaro CM, Compagnone D, Amorena M, Petrizzi L. Pharmacokinetics of marbofloxacin administered via intravenous regional limb perfusion in dairy cows: evaluation of two different tourniquets.. Vet Rec Open 2017;4(1):e000227.
- Spugnini EP, Bolaffio C, Scacco L, Baldi A. Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare.. Open Vet J 2017;7(2):192-196.
- Nieto JE, Trela J, Stanley SD, Yamout S, Snyder JR. Pharmacokinetics of a combination of amikacin sulfate and penicillin G sodium for intravenous regional limb perfusion in adult horses.. Can J Vet Res 2016 Jul;80(3):230-5.
- Dória RG, Carvalho MB, Freitas SH, Laskoski LM, Colodel EM, Mendonça FS, Silva MA, Grigoletto R, Fantinato Neto P. Evaluation of intravenous regional perfusion with amphotericin B and dimethylsulfoxide to treat horses for pythiosis of a limb.. BMC Vet Res 2015 Jul 16;11:152.
- Hunter BG, Duesterdieck-Zellmer KF, Larson MK. Tiludronate concentrations and cytologic findings in synovial fluid after intravenous regional limb perfusion with tiludronate in horses.. PeerJ 2015;3:e889.
- Hyde RM, Lynch TM, Clark CK, Slone DE, Hughes FE. The influence of perfusate volume on antimicrobial concentration in synovial fluid following intravenous regional limb perfusion in the standing horse.. Can Vet J 2013 Apr;54(4):363-7.
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