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Home / Equine Research Bank / Vet Sci / Antimicrobial Residue Accumulation Contributes to Higher Lev...
Veterinary sciences2024; 11(2); 92; doi: 10.3390/vetsci11020092

Antimicrobial Residue Accumulation Contributes to Higher Levels of Rhodococcus equi Carrying Resistance Genes in the Environment of Horse-Breeding Farms.

Abstract: Antimicrobial residues excreted in the environment following antimicrobial treatment enhance resistant microbial communities in the environment and have long-term effects on the selection and maintenance of antimicrobial resistance genes (AMRGs). In this study, we focused on understanding the impact of antimicrobial use on antimicrobial residue pollution and antimicrobial resistance (AMR) in the environment of horse-breeding farms. is an ideal microbe to study these associations because it lives naturally in the soil, exchanges AMRGs with other bacteria in the environment, and can cause disease in animals and humans. The environment is the main source of infections in foals; therefore, higher levels of multidrug-resistant (MDR) in the environment contribute to clinical infections with MDR . We found that macrolide residues in the environment of horse-breeding farms and the use of thoracic ultrasonographic screening (TUS) for early detection of subclinically affected foals with infections were strongly associated with the presence of carrying AMRGs in the soil. Our findings indicate that the use of TUS contributed to historically higher antimicrobial use in foals, leading to the accumulation of antimicrobial residues in the environment and enhancing MDR .
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Publication Date: 2024-02-17 PubMed ID: 38393110PubMed Central: PMC10892917DOI: 10.3390/vetsci11020092Google Scholar: Lookup
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APA
Higgins C, Cohen ND, Slovis N, Boersma M, Gaonkar PP, Golden DR, Huber L. (2024). Antimicrobial Residue Accumulation Contributes to Higher Levels of Rhodococcus equi Carrying Resistance Genes in the Environment of Horse-Breeding Farms. Vet Sci, 11(2), 92. https://doi.org/10.3390/vetsci11020092

Publication

Veterinary sciences
ISSN: 2306-7381
NlmUniqueID: 101680127
Country: Switzerland
Language: English
Volume: 11
Issue: 2
PII: 92

Researcher Affiliations

Higgins, Courtney
  • Pathobiology Department, College of Veterinary Medicine, Auburn University, Auburn, AL 36832, USA.
Cohen, Noah D
  • Large Animal Clinical Sciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M, College Station, TX 77843, USA.
Slovis, Nathan
  • Hagyard Equine Medical Institute, Lexington, KY 40511, USA.
Boersma, Melissa
  • College of Sciences and Mathematics, Auburn University, Auburn, AL 36849, USA.
Gaonkar, Pankaj P
  • Pathobiology Department, College of Veterinary Medicine, Auburn University, Auburn, AL 36832, USA.
Golden, Daniel R
  • Pathobiology Department, College of Veterinary Medicine, Auburn University, Auburn, AL 36832, USA.
Huber, Laura
  • Pathobiology Department, College of Veterinary Medicine, Auburn University, Auburn, AL 36832, USA.

Grant Funding

  • G00015610 / Grayson-Jockey Club Research Foundation

Conflict of Interest Statement

The authors declare no conflict of interest.

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Citations

This article has been cited 1 times.
  1. Baptiste KE, Kyvsgaard NC, Ahmed MO, Damborg P, Dowling PM. Is Rifampin (Rifampicin) Essential for the Treatment of Rhodococcus equi Infections in Foals? A Critical Review of the Role of Rifampin.. J Vet Pharmacol Ther 2025 Sep;48(5):345-358.
    doi: 10.1111/jvp.70007pubmed: 40552784google scholar: lookup
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