Antimicrobial susceptibility of Escherichia coli from swine, horses, dogs and cats as determined in the BfT-GermVet monitoring program 2004-2006.
Abstract: A total of 417 isolates of Escherichia coli collected from five animal species/organ system combinations from swine [urinary/genital tract (UGT) incl. mastitis metritis agalactia syndrome], horses [genital tract (GT)] and dogs/cats [respiratory tract (RT), UGT and gastrointestinal tract (GIT)] were analysed quantitatively for their susceptibility against different antimicrobial agents by determination of minimum inhibitory concentrations. Regardless of which animal species the strains originated from, resistance appeared most frequently against sulfamethoxazole (18-59%), tetracycline (14-54 %), and ampicillin (14-39%). High percentages of intermediate isolates were observed for cephalothin (39-46 %). In general, low prevalences of resistance were detected for amoxicillin/clavulanic acid (1-4%), gentamicin (1-9%), and cefazolin (0-11%). Generally speaking, the antimicrobial resistance situation among E. coli isolates from horses and small animals is relatively good.
Publication Date: 2007-10-18 PubMed ID: 17939454
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research analyzed the antibiotic resistance of 417 E. coli samples gathered from swine, horses, and domestic pets over a two-year period. The strains were found to have varying levels of resistance to different antimicrobial drugs, with the most frequent resistances being against sulfamethoxazole, tetracycline, and ampicillin.
Study Rationale and Methodology
- The study was conducted in response to the growing global concern about increasing antimicrobial resistance (AMR) in bacteria, which can render conventional treatments ineffective.
- The researchers selected Escherichia coli, a common bacterium, from five different animal species or organ systems for study.
- Using quantitative analysis, the minimum inhibitory concentrations of different antimicrobial drugs were determined. The inhibitory concentration is the minimum amount of a drug required to inhibit bacterial growth.
Findings
- The study found that regardless of the source animal, the E. coli strains showed the most resistance against sulfamethoxazole, tetracycline, and ampicillin.
- The strains also showed a significant number of intermediate isolates (partially resistant bacteria) for the antibiotic cephalothin.
- Lower levels of resistance were observed against amoxicillin/clavulanic acid, gentamicin, and cefazolin. This suggests that these antibiotics are likely still effective in treating E. coli infections in the species tested.
Implications
- The resistance levels indicated by this study suggest that selection of antibiotics should be tailored to the specific resistance profiles of E.coli strains from different animal species.
- The research also emphasizes the importance of ongoing monitoring and study of antimicrobial resistance in bacteria from diverse animal species and organ systems, as patterns of resistance can change over time.
Cite This Article
APA
Grobbel M, Lübke-Becker A, Alesík E, Schwarz S, Wallmann J, Werckenthin C, Wieler LH.
(2007).
Antimicrobial susceptibility of Escherichia coli from swine, horses, dogs and cats as determined in the BfT-GermVet monitoring program 2004-2006.
Berl Munch Tierarztl Wochenschr, 120(9-10), 391-401.
Publication
Researcher Affiliations
- Institut für Mikrobiologie und Tierseuchen, Fachbereich Veterinärmedizin, Freie Universität Berlin. grobbel.mirjam@vetmed.fu-berlin.de
MeSH Terms
- Animal Diseases / microbiology
- Animals
- Anti-Infective Agents / pharmacology
- Cats
- Dogs
- Drug Resistance, Bacterial
- Escherichia coli / drug effects
- Escherichia coli / isolation & purification
- Escherichia coli Infections / microbiology
- Escherichia coli Infections / veterinary
- Germany
- Government Programs
- Horses
- Microbial Sensitivity Tests / veterinary
- Swine
Citations
This article has been cited 7 times.- Feßler AT, Scholtzek AD, Schug AR, Kohn B, Weingart C, Hanke D, Schink AK, Bethe A, Lübke-Becker A, Schwarz S. Antimicrobial and Biocide Resistance among Canine and Feline Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii Isolates from Diagnostic Submissions.. Antibiotics (Basel) 2022 Jan 25;11(2).
- Sala A, Taddei S, Santospirito D, Sandri C, Magnone W, Cabassi CS. Antibiotic resistance in conjunctival and enteric bacterial flora in raptors housed in a zoological garden.. Vet Med Sci 2016 Nov;2(4):239-245.
- Marques C, Gama LT, Belas A, Bergström K, Beurlet S, Briend-Marchal A, Broens EM, Costa M, Criel D, Damborg P, van Dijk MA, van Dongen AM, Dorsch R, Espada CM, Gerber B, Kritsepi-Konstantinou M, Loncaric I, Mion D, Misic D, Movilla R, Overesch G, Perreten V, Roura X, Steenbergen J, Timofte D, Wolf G, Zanoni RG, Schmitt S, Guardabassi L, Pomba C. European multicenter study on antimicrobial resistance in bacteria isolated from companion animal urinary tract infections.. BMC Vet Res 2016 Sep 22;12(1):213.
- Shobrak MY, Abo-Amer AE. Role of wild birds as carriers of multi-drug resistant Escherichia coli and Escherichia vulneris.. Braz J Microbiol 2014;45(4):1199-209.
- Radhouani H, Silva N, Poeta P, Torres C, Correia S, Igrejas G. Potential impact of antimicrobial resistance in wildlife, environment and human health.. Front Microbiol 2014;5:23.
- Martinez-Medina M, Garcia-Gil J, Barnich N, Wieler LH, Ewers C. Adherent-invasive Escherichia coli phenotype displayed by intestinal pathogenic E. coli strains from cats, dogs, and swine.. Appl Environ Microbiol 2011 Aug 15;77(16):5813-7.
- Schink AK, Kadlec K, Schwarz S. Analysis of bla(CTX-M)-carrying plasmids from Escherichia coli isolates collected in the BfT-GermVet study.. Appl Environ Microbiol 2011 Oct;77(20):7142-6.
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