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Planta medica2020; 86(15); 1058-1072; doi: 10.1055/a-1224-6115

Antiviral Medicinal Plants of Veterinary Importance: A Literature Review.

Abstract: Viruses have a high mutation rate, and, thus, there is a continual emergence of new antiviral-resistant strains. Therefore, it becomes imperative to explore and develop new antiviral compounds continually. The search for pharmacological substances of plant origin that are effective against animal viruses, which have a high mortality rate or cause large economic losses, has garnered interest in the last few decades. This systematic review compiles 130 plant species that exhibit antiviral activity on 37 different virus species causing serious diseases in animals. The kind of extract, fraction, or compound exhibiting the antiviral activity and the design of the trial were particularly considered for review. The literature revealed details regarding plant species exhibiting antiviral activities against pathogenic animal virus species of the following families-, and that cause infections, among others, in poultry, cattle, pigs, horses, shrimps, and fish. Overall, 30 plant species exhibited activity against various influenza viruses, most of them causing avian influenza. Furthermore, 30 plant species were noted to be active against Newcastle disease virus. In addition, regarding the pathogens most frequently investigated, this review provides a compilation of 20 plant species active against bovine herpesvirus, 16 against fowlpox virus, 12 against white spot syndrome virus in marine shrimps, and 10 against suide herpesvirus. Nevertheless, some plant extracts, particularly their compounds, are promising candidates for the development of new antiviral remedies, which are urgently required.
Publication Date: 2020-08-10 PubMed ID: 32777833DOI: 10.1055/a-1224-6115Google Scholar: Lookup
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  • Journal Article
  • Systematic Review

Summary

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This research study reviews various plant species that have shown antiviral properties against different animal viruses. The aim is to discover potential new sources of antiviral compounds due to the continuing emergence of drug-resistant virus strains.

Objective of the Research

The primary objective of the study was to identify and compile a comprehensive list of plant species that display antiviral properties. This research is vital due to the high mutation rates in viruses that lead to the emergence of new antiviral-resistant strains. It was particularly focused on finding plant-based substances that could combat serious animal viruses causing high mortality rates and significant economic loss.

Methodology

  • The systematic review considered the kind of plant extract, fraction, or compound demonstrating the antiviral activity and the trial design.
  • It also compiled data of plant species that exhibited antiviral activities against various pathogenic animal virus species.

Major Findings

  • A total of 130 plant species were found to have antiviral activity on 37 different virus species causing serious diseases in various animals like poultry, cattle, pigs, horses, shrimps, and fish.
  • 30 plant species displayed activity against various influenza viruses, most of them causing avian influenza.
  • 30 plant species were active against Newcastle disease virus.
  • The researchers also provided a compilation of 20 plant species active against bovine herpesvirus, 16 against fowlpox virus, 12 against white spot syndrome virus in marine shrimps, and 10 against suide herpesvirus.

Conclusion

The study emphasizes that several plant species possess significant potential to counter various kinds of animal viruses. Particularly, some plant extracts and their compounds are promising candidates for the development of new antiviral remedies, which are urgently needed in the face of the constant challenge of drug-resistant viruses.

Cite This Article

APA
Zitterl-Eglseer K, Marschik T. (2020). Antiviral Medicinal Plants of Veterinary Importance: A Literature Review. Planta Med, 86(15), 1058-1072. https://doi.org/10.1055/a-1224-6115

Publication

ISSN: 1439-0221
NlmUniqueID: 0066751
Country: Germany
Language: English
Volume: 86
Issue: 15
Pages: 1058-1072

Researcher Affiliations

Zitterl-Eglseer, Karin
  • Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Vienna, Austria.
Marschik, Tatiana
  • Unit of Veterinary Public Health and Epidemiology, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Vienna, Austria.

MeSH Terms

  • Animal Diseases / therapy
  • Animals
  • Antiviral Agents / pharmacology
  • Cattle
  • Horses
  • Orthomyxoviridae
  • Plant Extracts / pharmacology
  • Plants, Medicinal
  • Swine
  • Veterinary Medicine

Conflict of Interest Statement

The authors declare that they have no conflict of interest.

Citations

This article has been cited 3 times.
  1. Nausch B, Bittner CB, Höller M, Abramov-Sommariva D, Hiergeist A, Gessner A. Contribution of Symptomatic, Herbal Treatment Options to Antibiotic Stewardship and Microbiotic Health.. Antibiotics (Basel) 2022 Sep 29;11(10).
    doi: 10.3390/antibiotics11101331pubmed: 36289988google scholar: lookup
  2. Pathak RK, Seo YJ, Kim JM. Structural insights into inhibition of PRRSV Nsp4 revealed by structure-based virtual screening, molecular dynamics, and MM-PBSA studies.. J Biol Eng 2022 Feb 22;16(1):4.
    doi: 10.1186/s13036-022-00284-xpubmed: 35193698google scholar: lookup
  3. Zhou GZ, Li J, Sun YH, Zhang Q, Zhang L, Pei C. Autophagy Delays Apoptotic Cell Death Induced by Siniperca chuatsi Rhabdovirus in Epithelioma Papulosum Cyprinid Cells.. Viruses 2021 Aug 6;13(8).
    doi: 10.3390/v13081554pubmed: 34452418google scholar: lookup