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Veterinary world2020; 13(8); 1685-1696; doi: 10.14202/vetworld.2020.1685-1696

Applications, challenges, and strategies in the use of nanoparticles as feed additives in equine nutrition.

Abstract: The rapid expansion of nanotechnology has been transforming the food industry by increasing market share and expenditure. Although nanotechnology offers promising benefits as feed additives, their usage in equines is primarily geared toward immunotherapy, hyper-immunization techniques, drug delivery systems, grooming activities, and therapeutic purposes. Nanoparticles could be engaged as alternatives for antibiotic feed additives to prevent foal diarrhea. Gold nanoparticles are proved to provide beneficial effects for racehorses by healing joint and tendon injuries. Because of the poor bioavailability of micro-sized mineral salts, the usage of nano-minerals is highly encourageable to improve the performance of racehorses. Nano-Vitamin E and enzyme CoQ10 for equines are no longer a simple research topic because of the increased commercial availability. Employing nanotechnology-based preservatives may offer a promising alternative to other conventional preservatives in preserving the quality of equine feed items, even during an extended storage period. While nanoparticles as feed additives may provide multitudinous benefits on equines, they could elicit allergic or toxic responses in case of improper synthesis aids or inappropriate dosages. The safety of nano-feed additives remains uninvestigated and necessitates the additional risk assessment, especially during their usage for a prolonged period. To adopt nano-feed additives in horses, there is an extreme paucity of information regarding the validity of various levels or forms of nanoparticles. Further, the currently available toxicological database on the topic of nano-feed additives is not at all related to equines and even inadequate for other livestock species. This review aims to provide new insights into possible future research pertaining to the usage of nano-feed additives in equines.
Copyright: © Reddy, et al.
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Publication Date: 2020-08-26 PubMed ID: 33061246PubMed Central: PMC7522939DOI: 10.14202/vetworld.2020.1685-1696Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the potential advantages and drawbacks of using nanoparticles as feed additives for horses, particularly in the areas of immunotherapy, drug delivery, physical health treatments, and grooming. The authors highlight the lack of adequate scientific data on the effects and safe dosage of such additives, emphasizing the need for more rigorous study and risk assessment.

Nanoparticles: A Promising Feed Additive in equines

  • The authors reveal how the burgeoning field of nanotechnology has begun infiltrating the food industry, including feed supplements for livestock.
  • The article discusses various potential applications for nanoparticles in equine care, such as enhancing feeding efficiency, serving as a vector for drugs or immunotherapy, and potentially replacing antibiotics to prevent filial diarrhea.
  • Specifically, gold nanoparticles are highlighted as beneficial for the treatment of joint and tendon injuries in racehorses, which are common and often career-ending afflictions.
  • Beyond physical health, nanoparticles may also be beneficial to the grooming and general wellbeing of horses. The inclusion of nano-minerals, instead of more traditional mineral salts, is suggested to improve horse performance.
  • Finally, nanotechnology-based preservatives may be a promising alternative to conventional preservatives for maintaining the quality of horse feed over long storage periods.

Challenges and Concerns about the use of Nanoparticles

  • Despite the potential benefits, the authors caution against indiscriminate nanoparticle use due to possible allergic or toxic reactions stemming from improper synthesis or dosage.
  • The use of nanoparticles as equine feed additives is in its nascent stages, and the potential risk they present if used over extended periods is largely unexplored. Therefore, the authors stress the need for further investigation and risk assessments to ensure the safety of their long-term use.
  • One of the main challenges highlighted in the article is the striking lack of information regarding appropriate nanoparticle doses. Without this information, safe and effective usage is impossible.

Further Research Needed

  • The authors suggest a pressing need for more comprehensive research in the field of nanotechnology as it relates to horse feed supplements. They argue that the current toxicological database is insufficient for equines and even inadequate for other livestock.
  • This review concludes by providing new avenues for possible future research, hoping to stimulate more in-depth exploration of nano-feed additives’ potential benefits and risks.

Cite This Article

APA
Reddy PRK, Yasaswini D, Reddy PPR, Zeineldin M, Adegbeye MJ, Hyder I. (2020). Applications, challenges, and strategies in the use of nanoparticles as feed additives in equine nutrition. Vet World, 13(8), 1685-1696. https://doi.org/10.14202/vetworld.2020.1685-1696

Publication

Veterinary world
ISSN: 0972-8988
NlmUniqueID: 101504872
Country: India
Language: English
Volume: 13
Issue: 8
Pages: 1685-1696

Researcher Affiliations

Reddy, P Ravi Kanth
  • Veterinary Dispensary, Taticherla, Andhra Pradesh, India.
Yasaswini, Duvvuru
  • Department of Veterinary Medicine, College of Veterinary Science, Sri Venkateswara Veterinary University, Tirupati, India.
Reddy, P Pandu Ranga
  • Livestock Farm Complex, College of Veterinary Science, Sri Venkateswara Veterinary University, Proddatur, Andhra Pradesh, India.
Zeineldin, Mohamed
  • Institute for Genomic Biology, University of Illinois at Urbana-Champaign, USA.
  • Department of Animal Medicine, College of Veterinary Medicine, Benha University, Benha, Egypt.
Adegbeye, M J
  • Department of Animal Science, College of Agriculture, Joseph Ayo Babalola University, Ikeji-Arakeji, Nigeria.
Hyder, Iqbal
  • Department of Veterinary Physiology, NTR College of Veterinary Science, Sri Venkateswara Veterinary University, Gannavaram, India.
  • Department of Biotechnology, Institute of Farm Animal Genetics, Friedrich Loeffler Institute, Neustadt, Hannover, Germany.

References

This article includes 67 references
  1. Garcia-Barrasa J, López-de-Luzuriaga J.M, Monge M. Silver nanoparticles: Synthesis through chemical methods in solution and biomedical applications.. Cent. Eur. J. Chem. 2011;9(1):7.
  2. Hartland A, Lead J.R, Slaveykova V, O'Carroll D, Valsami-Jones E. The environmental significance of natural nanoparticles.. Nat. Educ. Know. 2013;4(8):7–10.
  3. Gopi M, Pearlin B, Kumar R.D, Shanmathy M, Prabakar G. Role of nanoparticles in animal and poultry nutrition:Modes of action and applications in formulating feed additives and food processing.. Int. J. Pharmacol. 2017;13(7):724–731.
  4. Wang C, Zhang L, Ying Z, He J, Zhou L, Zhang L, Zhong X, Wang T. Effects of Dietary Zinc Oxide Nanoparticles on Growth, Diarrhea, Mineral Deposition, Intestinal Morphology, and Barrier of Weaned Piglets.. Biol Trace Elem Res 2018 Oct;185(2):364-374.
    pubmed: 29468613doi: 10.1007/s12011-018-1266-5google scholar: lookup
  5. Elghandour M.M.M, Reddy P.R.K, Salem A.Z.M, Reddy P.P.R, Hyder I, Barbsbosa-Pliego A, Yasaswini D. Plant bioactives and extracts as feed additives in horse nutrition.. J. Equine Vet. Sci. 2018;69(2018):66e77.
  6. Seven P.T, Seven I, Baykalir B.G, Mutlu S.I, Salem A.Z.M. Nanotechnology and nano-propolis in animal production and health: An overview.. Ital. J Anim. Sci. 2018;17(4):921e30.
  7. Scott A, Vadalasetty K.P, Chwalibog A, Sawosz E. Copper nanoparticles as an alternative feed additive in poultry: A review.. Nanotechnol. Rev. 2018;7(1):69–93.
  8. Thacker PA. Alternatives to antibiotics as growth promoters for use in swine production: a review.. J Anim Sci Biotechnol 2013 Sep 14;4(1):35.
    pmc: PMC3850713pubmed: 24034214doi: 10.1186/2049-1891-4-35google scholar: lookup
  9. Easa F.M, Refaie A.M, Morsy W.A, Hekil A.M. Effect of supplemental nano vs. conventional copper sources on growth performance of New Zealand white rabbits.. Egyp. J Rab. Sci. 2018;28(1):93–113.
  10. Adegbeye MJ, Elghandour MMMY, Barbabosa-Pliego A, Monroy JC, Mellado M, Ravi Kanth Reddy P, Salem AZM. Nanoparticles in Equine Nutrition: Mechanism of Action and Application as Feed Additives.. J Equine Vet Sci 2019 Jul;78:29-37.
    pubmed: 31203981doi: 10.1016/j.jevs.2019.04.001google scholar: lookup
  11. Xie Y, Liu Y, Yang J, Liu Y, Hu F, Zhu K, Jiang X. Gold Nanoclusters for Targeting Methicillin-Resistant Staphylococcus aureus In Vivo.. Angew Chem Int Ed Engl 2018 Apr 3;57(15):3958-3962.
    pubmed: 29423995doi: 10.1002/anie.201712878google scholar: lookup
  12. Mallicote M, House AM, Sanchez LC. A review of foal diarrhoea from birth to weaning.. Equine Vet Educ 2012 Apr;24(4):206-214.
    pmc: PMC7163619pubmed: 32313387doi: 10.1111/j.2042-3292.2011.00358.xgoogle scholar: lookup
  13. Tiwari V, Mishra N, Gadani K, Solanki PS, Shah NA, Tiwari M. Mechanism of Anti-bacterial Activity of Zinc Oxide Nanoparticle Against Carbapenem-Resistant Acinetobacter baumannii.. Front Microbiol 2018;9:1218.
    pmc: PMC5997932pubmed: 29928271doi: 10.3389/fmicb.2018.01218google scholar: lookup
  14. Marędziak M, Marycz K, Smieszek A, Lewandowski D, Toker NY. The influence of static magnetic fields on canine and equine mesenchymal stem cells derived from adipose tissue.. In Vitro Cell Dev Biol Anim 2014 Jun;50(6):562-71.
    pmc: PMC4062816pubmed: 24477562doi: 10.1007/s11626-013-9730-1google scholar: lookup
  15. Kojouri G.A, Faramarzi P, Ahadi A.M, Parchami A. Effect of selenium nanoparticles on expression of HSP90 gene in myocytes after an intense exercise.. J. Equine Vet. Sci. 2013;33(12):1054–1056.
  16. Kojouri G.A, Sharifi S. Preventing effects of nano-selenium particles on serum concentration of blood urea nitrogen, creatinine, and total protein during intense exercise in donkey.. J. Equine Vet. Sci. 2013;33(8):597–600.
  17. Hecold M, Buczkowska R, Mucha A, Grzesiak J, Mucha A, Grzesiak J, Rac-Rumijowska O, Teterycz H, Marycz K. The effect of PEI and PVP-stabilized gold nanoparticles on equine platelets activation: Potential application in equine regenerative medicine.. J Nanomater. 2017;2017:1–11.
  18. Khafaga A.F, Abu-Ahmed H.M, El-Khamary A.N, Elmehasseb I.M, Shaheen H.M. Enhancement of equid distal limb wounds healing by topical application of silver nanoparticles.. J. Equine Vet. Sci. 2018;61:76–87.
  19. Kamoun EA, Kenawy ES, Chen X. A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings.. J Adv Res 2017 May;8(3):217-233.
    pmc: PMC5315442pubmed: 28239493doi: 10.1016/j.jare.2017.01.005google scholar: lookup
  20. Fuchs S, Klier J, May A, Winter G, Coester C, Gehlen H. Towards an inhalative in vivo application of immunomodulating gelatin nanoparticles in horse-related preformulation studies.. J Microencapsul 2012;29(7):615-25.
    pubmed: 22432849doi: 10.3109/02652048.2012.668962google scholar: lookup
  21. Klier J, Fuchs S, May A, Schillinger U, Plank C, Winter G, Coester C, Gehlen H. A nebulized gelatin nanoparticle-based CpG formulation is effective in immunotherapy of allergic horses.. Pharm Res 2012 Jun;29(6):1650-7.
    pubmed: 22302522doi: 10.1007/s11095-012-0686-8google scholar: lookup
  22. Klier J, Lehmann B, Fuchs S, Reese S, Hirschmann A, Coester C, Winter G, Gehlen H. Nanoparticulate CpG immunotherapy in RAO-affected horses: phase I and IIa study.. J Vet Intern Med 2015 Jan;29(1):286-93.
    pmc: PMC4858074pubmed: 25619520doi: 10.1111/jvim.12524google scholar: lookup
  23. Klier J, Geis S, Steuer J, Geh K, Reese S, Fuchs S, Mueller RS, Winter G, Gehlen H. A comparison of nanoparticullate CpG immunotherapy with and without allergens in spontaneously equine asthma-affected horses, an animal model.. Immun Inflamm Dis 2018 Mar;6(1):81-96.
    pmc: PMC5818452pubmed: 29094511doi: 10.1002/iid3.198google scholar: lookup
  24. Geh K. Gelatine Nanoparticles as Immunomodulatory Drug Delivery System: Advanced Production Processes and Clinical Trials.. Dissertation, LMU München:Faculty of Chemistry and Pharmacy, A Dissertation Submitted to Ludwig Maximilian University of Munic, Germany. 2018.
  25. Mirzaei F, Mohammadpour Dounighi N, Avadi MR, Rezayat M. A New Approach to Antivenom Preparation Using Chitosan Nanoparticles Containing EchisCarinatus Venom as A Novel Antigen Delivery System.. Iran J Pharm Res 2017 Summer;16(3):858-867.
    pmc: PMC5610742pubmed: 29201077
  26. Manuja A, Dilbaghi N, Kaur H, Saini R, Barnela M, Chopra M, Manuja B.K, Kumar R, Kumar S, Riyesh T, Singh S.K. Chitosan quinapyramine sulfate nanoparticles exhibit increased trypanocidal activity in mice.. Nanostruct. Nanoobjec. 2018a;16:193–199.
  27. Manuja A, Kumar B, Kumar R, Chopra M, Dilbaghi N, Kumar S, Yadav SC. Biocompatibility and Targeting Efficiency of Encapsulated Quinapyramine Sulfate-Loaded Chitosan-Mannitol Nanoparticles in a Rabbit Model of Surra.. Antimicrob Agents Chemother 2018 Nov;62(11).
    pmc: PMC6201129pubmed: 30104283doi: 10.1128/aac.00466-18google scholar: lookup
  28. LaBauve AE, Rinker TE, Noureddine A, Serda RE, Howe JY, Sherman MB, Rasley A, Brinker CJ, Sasaki DY, Negrete OA. Lipid-Coated Mesoporous Silica Nanoparticles for the Delivery of the ML336 Antiviral to Inhibit Encephalitic Alphavirus Infection.. Sci Rep 2018 Sep 18;8(1):13990.
    pmc: PMC6143628pubmed: 30228359doi: 10.1038/s41598-018-32033-wgoogle scholar: lookup
  29. Wang M.Q, Wang C, Du Y.J, Li H, Tao W.J, Ye S.S, He Y.D, Chen S.Y. Effects of chromium-loaded chitosan nanoparticles on growth, carcass characteristics, pork quality, and lipid metabolism in finishing pigs.. Livest. Sci. 2014;161:123–129.
  30. Jampilek J, Kos J, Kralova K. Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes.. Nanomaterials (Basel) 2019 Feb 19;9(2).
    pmc: PMC6409737pubmed: 30791492doi: 10.3390/nano9020296google scholar: lookup
  31. Hill EK, Li J. Current and future prospects for nanotechnology in animal production.. J Anim Sci Biotechnol 2017;8:26.
    pmc: PMC5351054pubmed: 28316783doi: 10.1186/s40104-017-0157-5google scholar: lookup
  32. Singh T, Shukla S, Kumar P, Wahla V, Bajpai VK. Application of Nanotechnology in Food Science: Perception and Overview.. Front Microbiol 2017;8:1501.
    pmc: PMC5545585pubmed: 28824605doi: 10.3389/fmicb.2017.01501google scholar: lookup
  33. Sekhon BS. Food nanotechnology - an overview.. Nanotechnol Sci Appl 2010 May 4;3:1-15.
    pmc: PMC3781769pubmed: 24198465
  34. Akbari A, Wu J. Cruciferin nanoparticles: Preparation, characterization and their potential application in delivery of bioactive compounds.. Food Hydrocoll. 2016;54:107–118.
  35. Salvia-Trujillo L, Martín-Belloso O, McClements DJ. Excipient Nanoemulsions for Improving Oral Bioavailability of Bioactives.. Nanomaterials (Basel) 2016 Jan 14;6(1).
    pmc: PMC5302540pubmed: 28344274doi: 10.3390/nano6010017google scholar: lookup
  36. Boyles MS, Ranninger C, Reischl R, Rurik M, Tessadri R, Kohlbacher O, Duschl A, Huber CG. Copper oxide nanoparticle toxicity profiling using untargeted metabolomics.. Part Fibre Toxicol 2016 Sep 8;13(1):49.
    pmc: PMC5017021pubmed: 27609141doi: 10.1186/s12989-016-0160-6google scholar: lookup
  37. Sinatra S.T, Jankowitz S.N, Chopra R.K, Bhagavan H.N. Plasma coenzyme Q10 and tocopherols in thoroughbred race horses:Effect of coenzyme Q10 supplementation and exercise.. J. Equine Vet. Sci. 2014;34(2):265–269.
  38. Martin RG, McMeniman NP, Norton BW, Dowsett KF. Utilization of endogenous and dietary urea in the large intestine of the mature horse.. Br J Nutr 1996 Sep;76(3):373-86.
    pubmed: 8881710doi: 10.1079/bjn19960043google scholar: lookup
  39. Martin-Rosset W, Tisserand J.L. Evaluation and expression of protein allowances and protein value of feeds in the MADC system for the performance horse.. In: Julliand V, Martin-Rosset W, editors. Nutrition of the Performance Horse: Which System in Europe for Evaluating the Nutritional Requirements? Vol. 111. EAAP, Wageningen, Netherlands: Wageningen Academic Publishers; 2004. pp. 103–140.
  40. Ravi Kanth Reddy P, Srinivasa Kumar D, Raghava Rao E, Venkata Seshiah C, Sateesh K, Pradeep Kumar Reddy Y, Hyder I. Assessment of eco-sustainability vis-à-vis zoo-technical attributes of soybean meal (SBM) replacement with varying levels of coated urea in Nellore sheep (Ovis aries).. PLoS One 2019;14(8):e0220252.
    pmc: PMC6692044pubmed: 31408459doi: 10.1371/journal.pone.0220252google scholar: lookup
  41. Reddy PRK, Kumar DS, Rao ER, Seshiah CV, Sateesh K, Rao KA, Reddy YPK, Hyder I. Environmental sustainability assessment of tropical dairy buffalo farming vis-a-vis sustainable feed replacement strategy.. Sci Rep 2019 Nov 14;9(1):16745.
    pmc: PMC6856187pubmed: 31728009doi: 10.1038/s41598-019-53378-wgoogle scholar: lookup
  42. Kottegoda N, Sandaruwan C, Priyadarshana G, Siriwardhana A, Rathnayake UA, Berugoda Arachchige DM, Kumarasinghe AR, Dahanayake D, Karunaratne V, Amaratunga GA. Urea-Hydroxyapatite Nanohybrids for Slow Release of Nitrogen.. ACS Nano 2017 Feb 28;11(2):1214-1221.
    pubmed: 28121129doi: 10.1021/acsnano.6b07781google scholar: lookup
  43. Jones F.T. A review of practical Salmonella control measures in animal feed.. J. Appl. Poult. Res. 2011;20(1):102–113.
  44. Bunglavan S.J, Garg A.K, Dass R.S, Sameer S. Use of nanoparticles as feed additives to improve digestion and absorption in livestock.. Livest. Res. Int. 2014;2:36–47.
  45. . FDA's Approach to Regulation of Nanotechnology Products.. US Department of Health and Human Services, Food and Drug Administration (U.S. FDA), 2015.
  46. Horky P, Skalickova S, Baholet D, Skladanka J. Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins.. Nanomaterials (Basel) 2018 Sep 14;8(9).
    pmc: PMC6164963pubmed: 30223519doi: 10.3390/nano8090727google scholar: lookup
  47. He X, Hwang HM. Nanotechnology in food science: Functionality, applicability, and safety assessment.. J Food Drug Anal 2016 Oct;24(4):671-681.
    pubmed: 28911604doi: 10.1016/j.jfda.2016.06.001google scholar: lookup
  48. Ezhilarasi P.N, Karthik P, Chhanwal N, Anandharamakrishnan C. Nanoencapsulation techniques for food bioactive components: A review.. Food Bioproc. Tech. 2013;6:628–647.
  49. Wolny-Koładka K.A, Malina D.K. Toxicity assessment of silver nanoparticles against Escherichia coli strains isolated from horse dung.. Micro. Nano. Lett. 2017a;12(10):772–776.
  50. Wolny-Koładka KA, Malina DK. Silver nanoparticles toxicity against airborne strains of Staphylococcus spp.. J Environ Sci Health A Tox Hazard Subst Environ Eng 2017 Nov 10;52(13):1247-1256.
    pubmed: 28910572doi: 10.1080/10934529.2017.1356186google scholar: lookup
  51. Goodwin D, Davidson H.P.B, Harris P. Selection and acceptance of flavours in concentrate diets for stabled horses.. Appl. Anim. Behav. Sci. 2005;95(3-4):223–232.
  52. Dekkers S, Krystek P, Peters RJ, Lankveld DP, Bokkers BG, van Hoeven-Arentzen PH, Bouwmeester H, Oomen AG. Presence and risks of nanosilica in food products.. Nanotoxicology 2011 Sep;5(3):393-405.
    pubmed: 20868236doi: 10.3109/17435390.2010.519836google scholar: lookup
  53. Malheiros D.S.P, Daroit D.J, Brandelli A. Food applications of liposome-encapsulated antimicrobial peptides.. Trends Food Sci. Tech. 2010;21(6):284–292.
  54. Dubey JP, Bauer C. A review of Eimeria infections in horses and other equids.. Vet Parasitol 2018 May 30;256:58-70.
    pubmed: 29887031doi: 10.1016/j.vetpar.2018.04.010google scholar: lookup
  55. Raguvaran R, Anju M, Balvinder K.M. Zinc oxide nanoparticles: Opportunities and challenges in veterinary sciences.. Immunome. Res. 2015;11(2):95.
  56. Swain PS, Rao SBN, Rajendran D, Dominic G, Selvaraju S. Nano zinc, an alternative to conventional zinc as animal feed supplement: A review.. Anim Nutr 2016 Sep;2(3):134-141.
    pmc: PMC5941028pubmed: 29767083doi: 10.1016/j.aninu.2016.06.003google scholar: lookup
  57. Beaudrie C.E.H, Kandlikar M. Horses for courses: Risk information and decision making in the regulation of nanomaterials.. J. Nanopart. Res. 2011;13(4):1477–1488.
  58. Xiong S, George S, Yu H, Damoiseaux R, France B, Ng KW, Loo JS. Size influences the cytotoxicity of poly (lactic-co-glycolic acid) (PLGA) and titanium dioxide (TiO(2)) nanoparticles.. Arch Toxicol 2013 Jun;87(6):1075-86.
    pmc: PMC5657381pubmed: 22983807doi: 10.1007/s00204-012-0938-8google scholar: lookup
  59. Singh S, Chopra M, Dilbaghi N, Manuja BK, Kumar S, Kumar R, Rathore NS, Yadav SC, Manuja A. Synthesis and evaluation of isometamidium-alginate nanoparticles on equine mononuclear and red blood cells.. Int J Biol Macromol 2016 Nov;92:788-794.
    pubmed: 27471088doi: 10.1016/j.ijbiomac.2016.07.084google scholar: lookup
  60. Fondevila M, Herrer R, Casallas M.C, Abecia L, Ducha J.J. Potential use of silver nanoparticles as an additive in animal feeding.. Anim. Feed Sci. Technol. 2009;150(3):259–269.
  61. Akter N, Alam M.J, Jewel M.A.S, Ayenuddin M, Haque S.K, Akter S. Evaluation of dietary metallic iron nanoparticles as feed additive for growth and physiology of Bagridae catfish Clarias batrachus (Linnaeus, 1758) 2018.. Int. J. Fish Aqua. Stud. 2018;6(3):371–377.
  62. Tiptiri-Kourpeti A, Spyridopoulou K, Santarmaki V, Aindelis G, Tompoulidou E, Lamprianidou EE, Saxami G, Ypsilantis P, Lampri ES, Simopoulos C, Kotsianidis I, Galanis A, Kourkoutas Y, Dimitrellou D, Chlichlia K. Lactobacillus casei Exerts Anti-Proliferative Effects Accompanied by Apoptotic Cell Death and Up-Regulation of TRAIL in Colon Carcinoma Cells.. PLoS One 2016;11(2):e0147960.
    pmc: PMC4744000pubmed: 26849051doi: 10.1371/journal.pone.0147960google scholar: lookup
  63. Tian X, Jiang X, Welch C, Croley TR, Wong TY, Chen C, Fan S, Chong Y, Li R, Ge C, Chen C, Yin JJ. Bactericidal Effects of Silver Nanoparticles on Lactobacilli and the Underlying Mechanism.. ACS Appl Mater Interfaces 2018 Mar 14;10(10):8443-8450.
    pubmed: 29481051doi: 10.1021/acsami.7b17274google scholar: lookup
  64. Echegoyen Y, Rodríguez S, Nerín C. Nanoclay migration from food packaging materials.. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2016;33(3):530-9.
    pubmed: 26751017doi: 10.1080/19440049.2015.1136844google scholar: lookup
  65. Gunasekaran T, Nigusse T, Dhanaraju MD. Silver nanoparticles as real topical bullets for wound healing.. J Am Coll Clin Wound Spec 2011 Dec;3(4):82-96.
    pmc: PMC3921230pubmed: 24527370doi: 10.1016/j.jcws.2012.05.001google scholar: lookup
  66. Yoshida T, Yoshioka Y, Fujimura M, Yamashita K, Higashisaka K, Morishita Y, Kayamuro H, Nabeshi H, Nagano K, Abe Y, Kamada H, Tsunoda S, Itoh N, Yoshikawa T, Tsutsumi Y. Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice.. Nanoscale Res Lett 2011 Mar 4;6(1):195.
    pmc: PMC3211251pubmed: 21711705doi: 10.1186/1556-276x-6-195google scholar: lookup
  67. Godwin H, Nameth C, Avery D, Bergeson LL, Bernard D, Beryt E, Boyes W, Brown S, Clippinger AJ, Cohen Y, Doa M, Hendren CO, Holden P, Houck K, Kane AB, Klaessig F, Kodas T, Landsiedel R, Lynch I, Malloy T, Miller MB, Muller J, Oberdorster G, Petersen EJ, Pleus RC, Sayre P, Stone V, Sullivan KM, Tentschert J, Wallis P, Nel AE. Nanomaterial categorization for assessing risk potential to facilitate regulatory decision-making.. ACS Nano 2015;9(4):3409-17.
    pubmed: 25791861doi: 10.1021/acsnano.5b00941google scholar: lookup

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    doi: 10.1039/d1ra09072kpubmed: 35480371google scholar: lookup
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