Aqueous humor and plasma concentrations of a compounded 0.2% solution of terbinafine following topical ocular administration to normal equine eyes.
Abstract: To determine the transcorneal penetration and systemic absorption of a compounded 0.2% terbinafine solution following repeated topical administration to normal equine eyes. Sample population Six healthy adult horses with normal ocular examinations. Methods: One eye of each horse received 0.2 mL of a compounded 0.2% terbinafine solution every 4 h for seven doses. During the 1 h following administration of the final dose, multiple peripheral blood samples were obtained, and a single aqueous humor (AH) sample was collected at the end of the hour. AH and plasma concentrations of terbinafine were determined using high pressure liquid chromatography (HPLC). Stability of the formulation was assessed with HPLC analysis over a 14-day time period. Results: Terbinafine was not detected in the AH or plasma of any horse at any time point. No signs of ocular irritation or systemic toxicity were noted in any horse at any time point. The solution was stable over 14 days. Conclusions: Topical ocular administration of compounded 0.2% terbinafine solution does not result in detectable AH or plasma levels following administration to normal equine eyes, suggesting its use for deep corneal or intraocular fungal infections in equine ophthalmology may be limited.
© 2011 American College of Veterinary Ophthalmologists.
Publication Date: 2011-01-05 PubMed ID: 21199278DOI: 10.1111/j.1463-5224.2010.00841.xGoogle Scholar: Lookup
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Summary
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This research article details a study investigating the penetration and absorption of a specific medicinal solution, 0.2% terbinafine, into horse eyes when administered topically. It was found that this solution doesn’t reach detectable levels in the horse’s aqueous humor (part of the eye) or the bloodstream.
Study Objective and Methodology
- The main goal of the research was to assess the transcorneal penetration (the ability of the drug to penetrate the cornea of the eye) and systemic absorption (the amount of the drug that enters the bloodstream and helps in achieving the desired medicinal effects) of a compounded 0.2% terbinafine solution after repeated topical application to healthy horse eyes.
- In this experiment, one eye of each of the six healthy adult horses was treated with seven doses of the solution, each dose being administered every four hours.
- One hour after the final dose, multiple peripheral blood samples were collected and a single aqueous humor (the liquid within the eye) sample was also taken.
- The presence of terbinafine in the blood and the aqueous humor samples was determined using High-Pressure Liquid Chromatography (HPLC) technique.
- The study also evaluated the stability of the solution over a period of 14 days using the HPLC analysis.
Key Findings
- Contrary to expectations, terbinafine was not detected in either the aqueous humor or plasma of the horses at any time point.
- Moreover, the study did not observe any signs of ocular irritation or systemic toxicity in the horses across all the time points.
- The terbinafine solution was found to be stable over a 14-day period.
Conclusions
- The findings indicate that topical ocular administration of this particular kind of terbinafine solution doesn’t lead to detectable concentrations in the aqueous humor or plasma when applied to normal equine eyes.
- This suggests that the usefulness of this form of application for treating deep corneal or intraocular fungal infections in horses could be limited.
Cite This Article
APA
Clode A, Davis J, Davidson G, Salmon J, Lafevers H, Gilger B.
(2011).
Aqueous humor and plasma concentrations of a compounded 0.2% solution of terbinafine following topical ocular administration to normal equine eyes.
Vet Ophthalmol, 14(1), 41-47.
https://doi.org/10.1111/j.1463-5224.2010.00841.x Publication
Researcher Affiliations
- Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA. alison_clode@ncsu.edu
MeSH Terms
- Absorption
- Animals
- Antifungal Agents / administration & dosage
- Antifungal Agents / analysis
- Antifungal Agents / blood
- Antifungal Agents / pharmacokinetics
- Aqueous Humor / chemistry
- Chromatography, High Pressure Liquid / veterinary
- Cornea / metabolism
- Female
- Horses / metabolism
- Male
- Naphthalenes / administration & dosage
- Naphthalenes / analysis
- Naphthalenes / blood
- Naphthalenes / pharmacokinetics
- Ophthalmic Solutions
- Terbinafine
Citations
This article has been cited 3 times.- Foote BC, Smith JS, Bowden AC, Allbaugh RA, Sebbag L. Case Report: Successful Management of Refractory Keratomycosis in an Alpaca Using Penetrating Keratoplasty and Combination Antifungal Therapy (Caspofungin 0.5% and Terbinafine 1%). Front Vet Sci 2021;8:644074.
- Galera PD, Brooks DE. Optimal management of equine keratomycosis. Vet Med (Auckl) 2012;3:7-17.
- Marlo TL, Giuliano EA, Tripathi R, Sharma A, Mohan RR. Altering equine corneal fibroblast differentiation through Smad gene transfer. Vet Ophthalmol 2018 Mar;21(2):132-139.
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