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The Journal of veterinary medical science2023; 85(7); 751-754; doi: 10.1292/jvms.23-0158

Assessment of tetanus revaccination regimens in horses not vaccinated in the previous year.

Abstract: A two-dose revaccination against tetanus is recommended for horses over 2 years old in Japan with no history of vaccination in the previous year. Here, the need for two-dose revaccination was evaluated in terms of antibody titers for each vaccine type, namely monovalent or multivalent. There was no difference in antibody titers between one- and two-dose regimens for up to 1 year, except at 8 weeks with the multivalent vaccine, and all horses had sufficient antibody titers for 1 year of tetanus prophylaxis. These results suggest that one-dose revaccination, regardless of the vaccine type, is as effective as two-dose in preventing tetanus for at least 1 year in horses not vaccinated in the previous year.
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Publication Date: 2023-06-01 PubMed ID: 37258221PubMed Central: PMC10372253DOI: 10.1292/jvms.23-0158Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research attempts to determine whether one tetanus vaccination shot is as effective as two for horses older than two years, and that haven’t been vaccinated in the past year. The study indicated that, for up to one year, there was no significant difference between the two vaccination methods.

Objective of the Study

  • The main aim of the study was to assess the need for a two-dose revaccination regimen for horses over 2 years old in Japan that haven’t been vaccinated in the prior year.

Methodology

  • The study evaluated the need by comparing antibody titers for each vaccine type. The vaccine types used in the study were monovalent (single antigen) or multivalent (several antigens).
  • Antibody counts were observed for up to 1 year, with a distinction at 8 weeks for the multivalent vaccine.

Key Findings

  • The research found that there wasn’t any significant difference in antibody titers between horses who received one or two vaccine doses for up to 1 year, except for at the eight-week mark with the multivalent vaccine.
  • All the horses studied still had sufficiently high enough antibody titers to get tetanus prophylaxis for 1 year, despite the number of doses.

Conclusion

  • The findings of the study suggest that one-dose revaccination, no matter the type of vaccine used, appears just as effective as two-dose revaccination in preventing tetanus for at least 1 year in horses that hadn’t been vaccinated in the previous year.

Cite This Article

APA
Kinoshita Y, Yamanaka T, Kodaira K, Niwa H, Uchida-Fujii E, Ueno T. (2023). Assessment of tetanus revaccination regimens in horses not vaccinated in the previous year. J Vet Med Sci, 85(7), 751-754. https://doi.org/10.1292/jvms.23-0158

Publication

The Journal of veterinary medical science
ISSN: 1347-7439
NlmUniqueID: 9105360
Country: Japan
Language: English
Volume: 85
Issue: 7
Pages: 751-754

Researcher Affiliations

Kinoshita, Yuta
  • Microbiology Division, Equine Research Institute, Japan Racing Association, Tochigi, Japan.
Yamanaka, Takashi
  • Research Planning and Coordination Division, Equine Research Institute, Japan Racing Association, Tochigi, Japan.
Kodaira, Kazumichi
  • Racehorse Rehabilitation Center, Fukushima, Japan.
Niwa, Hidekazu
  • Microbiology Division, Equine Research Institute, Japan Racing Association, Tochigi, Japan.
Uchida-Fujii, Eri
  • Microbiology Division, Equine Research Institute, Japan Racing Association, Tochigi, Japan.
Ueno, Takanori
  • Microbiology Division, Equine Research Institute, Japan Racing Association, Tochigi, Japan.

MeSH Terms

  • Horses
  • Animals
  • Tetanus / prevention & control
  • Tetanus / veterinary
  • Immunization, Secondary / veterinary
  • Tetanus Toxoid
  • Vaccination / veterinary
  • Japan
  • Antibodies, Bacterial
  • Horse Diseases / prevention & control

Conflict of Interest Statement

The authors have no conflicts of interest to declare.

References

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Citations

This article has been cited 2 times.
  1. Shitada C, Ohira M, Sekiguchi M, Koda T, Takahashi M, Kuroda M. Characterization of a Highly Toxigenic Clostridium tetani Strain from a Calf's Castration Site. Vet Sci 2025 Sep 30;12(10).
    doi: 10.3390/vetsci12100945pubmed: 41150085google scholar: lookup
  2. Perzyna M, Grzędzicka J, Milczek-Haduch D, Dąbrowska I, Trela M, Pawliński B, Witkowska-Piłaszewicz O. Immunological Responses to Tetanus and Influenza Vaccination in Donkeys. J Vet Intern Med 2025 Jul-Aug;39(4):e70137.
    doi: 10.1111/jvim.70137pubmed: 40413721google scholar: lookup
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